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Effects of ashwagandha (Withania somnifera) on mental health in adults: A systematic review and dose-response meta-analysis of randomized controlled trials.

1. Complement Ther Med. 2026 May;97:103325. doi: 10.1016/j.ctim.2026.103325. Epub 2026 Feb 3. Effects of ashwagandha (Withania somnifera) on mental health in adults: A systematic review and dose-response meta-analysis of randomized controlled trials. Alsanie SA(1), Alhodieb FS(2), Askarpour M(3

Dual impact of Ashwagandha: Significant cortisol reduction but no effects on perceived stress - A systematic review and meta-analysis.

2. Nutr Health. 2025 Dec;31(4):1395-1408. doi: 10.1177/02601060251363647. Epub 2025 Aug 1. Dual impact of Ashwagandha: Significant cortisol reduction but no effects on perceived stress - A systematic review and meta-analysis. Albalawi AA(1). Author information: (1)Department of Rehabilitation S

Effects of Ashwagandha (Withania somnifera) on VO(2max): A Systematic Review and Meta-Analysis.

3. Nutrients. 2020 Apr 17;12(4):1119. doi: 10.3390/nu12041119. Effects of Ashwagandha (Withania somnifera) on VO(2max): A Systematic Review and Meta-Analysis. Pérez-Gómez J(1), Villafaina S(2), Adsuar JC(1), Merellano-Navarro E(3), Collado-Mateo D(4). Author information: (1)HEME Research Group,

A proprietary herbal extract of ashwagandha root for stress and anxiety in healthy adults: a randomized, double-blind, three-arm, placebo-controlled efficacy and safety study.

4. J Med Life. 2026 Jan;19(1):49-62. doi: 10.25122/jml-2025-0172. A proprietary herbal extract of ashwagandha root for stress and anxiety in healthy adults: a randomized, double-blind, three-arm, placebo-controlled efficacy and safety study. West RE(1), Biswas A(2), Rao R(3), Tayade H(4), Ademol

Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study.

5. J Med Life. 2025 Dec;18(12):1140-1154. doi: 10.25122/jml-2025-0147. Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study. Pakhale K(1), Pakhale R(2), Srivathsan M(3), L

Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study.

6. J Psychopharmacol. 2025 Apr;39(4):350-363. doi: 10.1177/02698811251324377. Epub 2025 Mar 18. Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study. Rai HP(1

Effects of Root Extract of Ashwagandha (Withania somnifera) on Perception of Recovery and Muscle Strength in Female Athletes.

7. Eur J Sport Sci. 2025 Mar;25(3):e12265. doi: 10.1002/ejsc.12265. Effects of Root Extract of Ashwagandha (Withania somnifera) on Perception of Recovery and Muscle Strength in Female Athletes. Coope OC(1), Reales Salguero A(2), Spurr T(3), Páez Calvente A(2), Domenech Farre A(2), Jordán Fisas E

Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.

8. J Psychoactive Drugs. 2026 Jan-Mar;58(1):45-57. doi: 10.1080/02791072.2024.2424279. Epub 2024 Nov 5. Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study. Kale S(1), Lopresti A(2), Suri R(1), Garg N

Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO (2max) in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study.

9. F1000Res. 2024 Apr 8;12:335. doi: 10.12688/f1000research.130932.2. eCollection 2023. Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO (2max) in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blin

Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.

10. Nutrients. 2024 Jun 8;16(12):1813. doi: 10.3390/nu16121813. Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood. Leonard M(1), Dickerson B(1), Estes L(1), Gonzalez DE(1), Jenkins V(1), Johnson S(1), Xing D(1), Yoo C(1), Ko J(1), Purpura M(2), Jäger

Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial.

11. J Psychopharmacol. 2023 Nov;37(11):1091-1104. doi: 10.1177/02698811231200023. Epub 2023 Sep 23. Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind,

Ashwagandha (Withania somnifera) and Shunthi (Zingiber officinale) in mild and moderate COVID-19: An open-label randomized controlled exploratory trial.

12. Complement Ther Med. 2023 Sep;76:102966. doi: 10.1016/j.ctim.2023.102966. Epub 2023 Jul 22. Ashwagandha (Withania somnifera) and Shunthi (Zingiber officinale) in mild and moderate COVID-19: An open-label randomized controlled exploratory trial. Singh H(1), Yadav B(2), Rai AK(3), Srivastava S

Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study.

13. J Obstet Gynaecol Res. 2021 Dec;47(12):4414-4425. doi: 10.1111/jog.15030. Epub 2021 Sep 22. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. Gopal S(1), Ajgaonkar A(2), Kan

Ashwagandha (Withania somnifera) Plant Extracts Affect the Cytochrome P450 System and Cytotoxicity of Primary Human Hepatocytes.

14. J Diet Suppl. 2025;22(4):613-639. doi: 10.1080/19390211.2025.2514458. Epub 2025 Jun 24. Ashwagandha (Withania somnifera) Plant Extracts Affect the Cytochrome P450 System and Cytotoxicity of Primary Human Hepatocytes. McDonald KL(1), Raichura Z(1), Pondugula SR(2), Marney L(3)(4), Yang L(3)(4

Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.

15. Ann Agric Environ Med. 2026 Mar 25;33(1):3-11. doi: 10.26444/aaem/213417. Epub 2025 Dec 9. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes. Łuszczak J(1), Kocki J(2). Author

Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis.

39. Explore (NY). 2024 Nov-Dec;20(6):103062. doi: 10.1016/j.explore.2024.103062. Epub 2024 Sep 21. Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis. Arumugam V(1), Vijayakumar V(2), Balakrishnan A(3), B Bhandari R(4), Boopalan D(5), Ponnur

Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.

47. PLoS One. 2021 Sep 24;16(9):e0257843. doi: 10.1371/journal.pone.0257843. eCollection 2021. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. Cheah KL(1), Norhayati MN(1), Husniati Yaacob L(1), Abdul Rahman R(1). Author information: (1)Depart

An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera).

10. J Altern Complement Med. 2014 Dec;20(12):901-8. doi: 10.1089/acm.2014.0177. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Pratte MA(1), Nanavati KB, Young V, Morley CP. Author information: (1