블루베리 추출물

A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging.

1. J Cosmet Dermatol. 2025 Jul;24(7):e70281. doi: 10.1111/jocd.70281. A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging.

Effects of a Blend of Trisodium Citrate, Creatine Monohydrate, Leucine, and Blueberry Extract on Training-Induced Changes in Leg Extension Strength, Endurance, and Muscle Size.

2. J Diet Suppl. 2025;22(4):584-612. doi: 10.1080/19390211.2025.2518408. Epub 2025 Jun 19. Effects of a Blend of Trisodium Citrate, Creatine Monohydrate, Leucine, and Blueberry Extract on Training-Induced Changes in Leg Extension Strength, Endurance, and Muscle Size. Roberts TD(1), Arnett JE(1)

Wild Blueberry Extract Intervention in Healthy Older Adults: A Multi-Study, Randomised, Controlled Investigation of Acute Cognitive and Cardiovascular Effects.

3. Nutrients. 2024 Apr 16;16(8):1180. doi: 10.3390/nu16081180. Wild Blueberry Extract Intervention in Healthy Older Adults: A Multi-Study, Randomised, Controlled Investigation of Acute Cognitive and Cardiovascular Effects. Cheng N(1), Barfoot KL(1), Le Cozannet R(2), Fança-Berthon P(2), Lamport

Dual protective effect of the association of plant extracts and fluoride against dentine erosion: In the presence and absence of salivary pellicle.

4. PLoS One. 2023 May 18;18(5):e0285931. doi: 10.1371/journal.pone.0285931. eCollection 2023. Dual protective effect of the association of plant extracts and fluoride against dentine erosion: In the presence and absence of salivary pellicle. Niemeyer SH(1), Jovanovic N(1), Sezer S(1), Wittwer LS

Plant extracts have dual mechanism on the protection against dentine erosion: action on the dentine substrate and modification of the salivary pellicle.

5. Sci Rep. 2023 May 1;13(1):7089. doi: 10.1038/s41598-023-34256-y. Plant extracts have dual mechanism on the protection against dentine erosion: action on the dentine substrate and modification of the salivary pellicle. Niemeyer SH(1), Baumann T(2), Lussi A(2), Scaramucci T(3), Carvalho TS(2).

The effects of phosphocreatine disodium salts plus blueberry extract supplementation on muscular strength, power, and endurance.

6. J Int Soc Sports Nutr. 2021 Sep 9;18(1):60. doi: 10.1186/s12970-021-00456-y. The effects of phosphocreatine disodium salts plus blueberry extract supplementation on muscular strength, power, and endurance. Anders JPV(1), Neltner TJ(2), Smith RW(2), Keller JL(3), Housh TJ(2), Daugherty FJ(4),

Physicochemical interactions of metformin hydrochloride and glibenclamide with several health foods.

7. Yakugaku Zasshi. 2008 Sep;128(9):1341-5. doi: 10.1248/yakushi.128.1341. Physicochemical interactions of metformin hydrochloride and glibenclamide with several health foods. Iwao K(1), Kawai RT, Oda M, Kobayashi M, Saitoh H. Author information: (1)Department of Pharmaceutics, Faculty of Pharma

Effects of blueberry and cranberry consumption on type 2 diabetes glycemic control: A systematic review.

8. Crit Rev Food Sci Nutr. 2019;59(11):1816-1828. doi: 10.1080/10408398.2018.1430019. Epub 2018 Feb 13. Effects of blueberry and cranberry consumption on type 2 diabetes glycemic control: A systematic review. Rocha DMUP(1), Caldas APS(1), da Silva BP(1), Hermsdorff HHM(1), Alfenas RCG(1). Autho

Selective dietary supplementation in early postpartum is associated with high resilience against depressed mood.

1. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3509-3514. doi: 10.1073/pnas.1611965114. Epub 2017 Mar 13. Selective dietary supplementation in early postpartum is associated with high resilience against depressed mood. Dowlati Y(1)(2)(3), Ravindran AV(1)(2)(3), Segal ZV(4), Stewart DE(2)(3)(5), Steiner M(2)(3)(6), Meyer JH(7)(2)(3). Author information: (1)Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8. (2)Institute of Medical Science, University of Toronto, Toronto, ON, Canada; M5S 1A8. (3)Department of Psychiatry, University of Toronto, Toronto, ON, Canada M5T1R8. (4)Department of Psychology, University of Toronto, Toronto, ON, Canada M5S 3G3. (5)Toronto General Hospital Research Institute, Toronto, ON, Canada M5G 2C4. (6)Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada L8S 4L8. (7)Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8; jeff.meyer@camhpet.ca. Medical research is moving toward prevention strategies during prodromal states. Postpartum blues (PPB) is often a prodromal state for postpartum depression (PPD), with severe PPB strongly associated with an elevated risk for PPD. The most common complication of childbearing, PPD has a prevalence of 13%, but there are no widespread prevention strategies, and no nutraceutical interventions have been developed. To counter the effects of the 40% increase in monoamine oxidase A (MAO-A) levels that occurs during PPB, a dietary supplement kit consisting of monoamine precursor amino acids and dietary antioxidants was created. Key ingredients (tryptophan and tyrosine) were shown not to affect their total concentration in breast milk. The aim of this open-label study was to assess whether this dietary supplement reduces vulnerability to depressed mood at postpartum day 5, the typical peak of PPB. Forty-one healthy women completed all study procedures. One group (n = 21) received the dietary supplement, composed of 2 g of tryptophan, 10 g of tyrosine, and blueberry juice with blueberry extract. The control group (n = 20) did not receive any supplement. PPB severity was quantitated by the elevation in depressed mood on a visual analog scale following the sad mood induction procedure (MIP). Following the MIP, there was a robust induction of depressed mood in the control group, but no effect in the supplement group [43.85 ± 18.98 mm vs. 0.05 ± 9.57 mm shift; effect size: 2.9; F(1,39) = 88.33, P < 0.001]. This dietary supplement designed to counter functions of elevated MAO-A activity eliminates vulnerability to depressed mood during the peak of PPB. DOI: 10.1073/pnas.1611965114 PMCID: PMC5380083 PMID: 28289215 [Indexed for MEDLINE] Conflict of interest statement: Conflict of interest statement: Y.D. is developing natural health products to overcome a high MAO-A state in early postpartum. J.H.M. has received operating grant funding for other studies from Eli Lilly, GlaxoSmithKline, Bristol-Myers Squibb, Lundbeck, SK Life Science, and Johnson & Johnson/Janssen in the past 5 years. J.H.M. has served as a consultant for all of these companies except Johnson & Johnson, as well as for Sepracor, Trius Therapeutics, and Mylan Inc. None of these companies participated in the funding, design, or execution of this study or preparation of the manuscript. J.H.M. is developing natural health products to treat high-risk states for major depressive episode, and is listed as the inventor on a patent application for this dietary supplement. J.H.M. is applying for patents to implement measures using MAO to diagnose or treat mood disorders and to use peripheral measures as surrogate measures for brain inflammation. Z.V.S. receives royalties from Guilford Press for books related to mindfulness-based cognitive therapy and fees for training workshops. He also serves on the advisory board of MindfulNoggin, part of NogginLabs, a private company specializing in customized web-based learning. D.E.S. is a member of the scientific advisory board for the Cymbalta (duloxetine) Pregnancy Registry for Eli Lilly. She is a co-author of UpToDate chapters on antidepressant drugs during pregnancy and their effects on exposed infants. A.V.R. and M.S. do not have any conflicts of interest related to this work.

The protective effects of a polyphenol-enriched protein powder on exercise-induced susceptibility to virus infection.

2. Phytother Res. 2014 Dec;28(12):1829-36. doi: 10.1002/ptr.5208. Epub 2014 Aug 2. The protective effects of a polyphenol-enriched protein powder on exercise-induced susceptibility to virus infection. Ahmed M(1), Henson DA, Sanderson MC, Nieman DC, Gillitt ND, Lila MA. Author information: (1)Department of Biology, Appalachian State University, Boone, NC, 28608, USA. Prolonged and intensive exercise induces transient immunosuppression and is associated with an increased risk and severity of infections. The goal of this study was to characterize the antiviral and antibacterial properties of the bioactive metabolites of a blueberry-green tea-polyphenol soy protein complex (PSPC) in the serum of supplemented subjects during a 3-day intensified training period. Long-distance runners, randomly divided into two groups, ingested 40 g/day PSPC or placebo (soy protein and colorings) for 17 days, with a 3-day running period inserted at day 14. Blood serum samples were collected pre-14 days and post-14 days supplementation, and immediately and 14 h after the third day of running. The post-exercise serum from both groups significantly promoted the growth of Escherichia coli and Staphylococcus aureus in culture by 20-70%, but returned to normal levels following recovery. Furthermore, the serum from subjects ingesting PSPC did not display antibacterial properties at any time point. In contrast, there was a significant difference in the ability of serum from PSPC-supplemented versus placebo-supplemented athletes to protect cells in culture from killing by vesicular stomatitis virus following strenuous exercise. In addition, the serum of subjects who ingested PSPC significantly delayed an exercise-induced increase in virus replication. These results indicate that polyphenol complexes containing blueberry and green tea have the potential to protect athletes from virus infections following rigorous exercise. Copyright © 2014 John Wiley & Sons, Ltd. DOI: 10.1002/ptr.5208 PMID: 25088029 [Indexed for MEDLINE]

Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women.

3. J Dermatolog Treat. 2004 Jul;15(4):222-6. doi: 10.1080/09546630410033772. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. Segger D(1), Schönlau F. Author information: (1)Skin Investigation and Technology, 20354 Hamburg, Germany. d.segger@t-online.de OBJECTIVE: To investigate whether nutritional intervention with a proprietary formulation and other micronutrients may favourably alter skin roughness and elasticity. METHODS: Sixty-two women aged 45-73 years participated in a double-blind, placebo-controlled trial testing the efficacy of a proprietary oral supplement for skin nutrition (Evelle), for improvement of skin elasticity and roughness. The active ingredients were vitamins C and E, carotenoids, selenium, zinc, amino acids and glycosaminoglycans, blueberry extract and Pycnogenol. RESULTS: Skin elasticity, measured using an optical cutometer, was found to be statistically significantly increased by 9% after 6 weeks of treatment compared with placebo (p=0.0351). Skin roughness, as evaluated by three-dimensional microtopography imaging, was found to be statistically significantly lowered by 6% compared with the control group after 12 weeks treatment (p=0.0157). CONCLUSION: Evelle can potentially improve visible signs of cutaneous ageing. DOI: 10.1080/09546630410033772 PMID: 15764035 [Indexed for MEDLINE]

A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans.

4. Nutrients. 2020 Jul 28;12(8):2254. doi: 10.3390/nu12082254. A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans. Jackson PA(1), Wightman EL(1)(2), Veasey R(1), Forster J(1), Khan J(1), Saunders C(3), Mitchell S(3), Haskell-Ramsay CF(1), Kennedy DO(1). Author information: (1)Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK. (2)NUTRAN, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK. (3)PepsiCo, Nutrition Sciences Global R&D, 700 Anderson Hill Rd, Purchase, NY 10577, USA. BACKGROUND: In whole foods, polyphenols exist alongside a wide array of other potentially bioactive phytochemicals. Yet, investigations of the effects of combinations of polyphenols with other phytochemicals are limited. OBJECTIVE: The current study investigated the effects of combining extracts of beetroot, ginseng and sage with phenolic-rich apple, blueberry and coffee berry extracts. DESIGN: This randomized, double-blind, placebo-controlled crossover design investigated three active beverages in 32 healthy adults aged 18-49 years. Each investigational beverage comprised extracts of beetroot, ginseng and sage. Each also contained a phenolic-rich extract derived from apple (containing 234 mg flavanols), blueberry (300 mg anthocyanins) or coffee berry (440 mg chlorogenic acid). Cognition, mood and CBF parameters were assessed at baseline and then again at 60, 180 and 360 min post-drink. RESULTS: Robust effects on mood and CBF were seen for the apple and coffee berry beverages, with increased subjective energetic arousal and hemodynamic responses being observed. Fewer effects were seen with the blueberry extract beverage. CONCLUSIONS: Either the combination of beetroot, ginseng and sage was enhanced by the synergistic addition of the apple and coffee berry extract (and to a lesser extent the blueberry extract) or the former two phenolic-rich extracts were capable of evincing the robust mood and CBF effects alone. DOI: 10.3390/nu12082254 PMCID: PMC7468953 PMID: 32731478 [Indexed for MEDLINE] Conflict of interest statement: C.S. and S.M are employees of PepsiCo, the sponsors of this study. C.S. contributed to the design of the protocol and both to the writing of the paper but had no role in collection, analysis or interpretation of the results.

A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults.

5. Nutrients. 2018 May 23;10(6):660. doi: 10.3390/nu10060660. A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults. Whyte AR(1), Cheng N(2), Fromentin E(3), Williams CM(4). Author information: (1)School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK. a.r.whyte@reading.ac.uk. (2)School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK. nancy.cheng@pgr.reading.ac.uk. (3)Naturex Inc., 375 Huyler Street, South Hackensack, NJ 07606, USA. e.fromentin@naturex-dbs.com. (4)School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK. claire.williams@reading.ac.uk. Previous research has shown beneficial effects of polyphenol-rich diets in ameliorating cognitive decline in aging adults. Here, using a randomized, double blinded, placebo-controlled chronic intervention, we investigated the effect of two proprietary blueberry formulations on cognitive performance in older adults; a whole wild blueberry powder at 500 mg (WBP500) and 1000 mg (WBP1000) and a purified extract at 100 mg (WBE111). One hundred and twenty-two older adults (65⁻80 years) were randomly allocated to a 6-month, daily regimen of either placebo or one of the three interventions. Participants were tested at baseline, 3, and 6 months on a battery of cognitive tasks targeting episodic memory, working memory and executive function, alongside mood and cardiovascular health parameters. Linear mixed model analysis found intervention to be a significant predictor of delayed word recognition on the Reys Auditory Verbal Learning Task (RAVLT), with simple contrast analysis revealing significantly better performance following WBE111 at 3 months. Similarly, performance on the Corsi Block task was predicted by treatment, with simple contrast analysis revealing a trend for better performance at 3 months following WBE111. Treatment also significantly predicted systolic blood pressure (SBP) with simple contrast analysis revealing lower SBP following intervention with WBE111 in comparison to placebo. These results indicate 3 months intervention with WBE111 can facilitate better episodic memory performance in an elderly population and reduce cardiovascular risk factors over 6 months. DOI: 10.3390/nu10060660 PMCID: PMC6024810 PMID: 29882843 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest. The funding sponsors contributed to the design of the study and writing of the manuscript, but had no role in the collection, analyses, or interpretation of data; and in the decision to publish the results.

The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication: a randomised controlled trial.

6. Int J Food Sci Nutr. 2016;67(2):177-83. doi: 10.3109/09637486.2016.1144716. Epub 2016 Feb 16. The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication: a randomised controlled trial. Chua CS(1)(2)(3)(4), Yang KC(5), Chen JH(2), Liu YH(2), Hsu YH(2), Lee HC(1), Huang SY(1). Author information: (1)a School of Nutrition and Health Sciences , Taipei Medical University , Taipei , Taiwan ; (2)b Division of Gastroenterology, Department of Internal Medicine , Shin Kong Wu Ho-Su Memorial Hospital , Taipei , Taiwan ; (3)c Graduate Institute of Biomedical Informatics, Taipei Medical University , Taipei , Taiwan ; (4)d Department of Gastroenterology , Hospital Lam Wah Ee , Penang , Malaysia ; (5)e School of Medicine , Taipei Medical University , Taipei , Taiwan. Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and gastric cancer. Traditional therapy with proton pump inhibitor and antibiotics is regarded as optimal for H. pylori eradication whereas, the eradication rate is unsatisfactory. Studies have reported that cranberry may inhibit H. pylori adhesion to the human gastric mucus but lack of other berry extracts have been evaluated in clinical study. Thus, a 9-week add-on randomised controlled trial was conducted to explore the impact of blueberry and grape seed extract (BGE) combinations traditional therapy for H. pylori eradication. In results, we found that there was no significant difference of eradication rate between the berry extract group and placebo group in the intention-to-treat analysis and in the per-protocol analysis (94.64% versus 84.62%, p = 0.085). Diarrhoea, constipation and epigastric pain were observed increasing during ingestion of the berry extract in some cases. In conclusion, this study indicated that no significant difference existed between the BGE extract group and placebo group in eradication rate under triple therapy. DOI: 10.3109/09637486.2016.1144716 PMID: 26883189 [Indexed for MEDLINE]

Uptake and bioavailability of anthocyanins and phenolic acids from grape/blueberry juice and smoothie in vitro and in vivo.

7. Br J Nutr. 2015 Apr 14;113(7):1044-55. doi: 10.1017/S0007114515000161. Epub 2015 Mar 17. Uptake and bioavailability of anthocyanins and phenolic acids from grape/blueberry juice and smoothie in vitro and in vivo. Kuntz S(1), Rudloff S(1), Asseburg H(1), Borsch C(1), Fröhling B(2), Unger F(3), Dold S(3), Spengler B(3), Römpp A(3), Kunz C(1). Author information: (1)Institute of Nutritional Science, Justus-Liebig-University Giessen,Wilhelmstrasse 20,35392Giessen,Germany. (2)Geisenheim Research Center, Section of Wine Analysis and Beverage Technology,Geisenheim,Germany. (3)Institute of Inorganic and Analytical Chemistry, Justus-Liebig-University,Giessen,Germany. The goal of eating five servings of fruits and vegetables a day has not yet been achieved. The intake of polyphenols such as anthocyanins (ACN) could be improved by consuming smoothies and juices that are increasingly popular, especially in children; however, bioavailability data concerning food matrix effects are scarce. Thus, we conducted a randomised, cross-over, bioavailability study (n 10) to determine the bioavailability of ACN and their metabolites from an ACN-rich grape/blueberry juice (841 mg ACN/litre) and smoothie (983 mg ACN/litre) in vivo, and the uptake of a corresponding grape/blueberry extract in vitro. After the intake of beverage (0·33 litres), plasma and fractionated urine samples were collected and analysed by ultra-performance liquid chromatography coupled to MS. The most abundant ACN found in plasma and urine were malvidin and peonidin as native ACN and as glucuronidated metabolites as well as 3,4-dihydroxybenzoic acid (3,4-DHB); minor ACN (delphinidin, cyanidin and petunidin) were only detected as native glycosides. Plasma pharmacokinetics and recoveries of urinary metabolites of ACN were not different for juice or smoothie intake; however, the phenolic acid 3,4-DHB was significantly better bioavailable from juice in comparison to smoothie. In vitro data with absorptive intestinal cells indicated that despite their weak chemical stability, ACN and 3,4-DHB could be detected at the basal side in their native forms. Whether smoothies as well as juices should be recommended to increase the intake of potentially health-promoting ACN and other polyphenols requires the consideration of other ingredients such as their relatively high sugar content. DOI: 10.1017/S0007114515000161 PMID: 25778541 [Indexed for MEDLINE]