브로멜라인

Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study.

1. Sci Rep. 2025 Nov 28;15(1):42799. doi: 10.1038/s41598-025-26975-1. Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study. Delgarm P(1), Mokhtare M(2), Ebrahimi Daryani N(3), Abolgh

Systemic enzyme therapy for postoperative inflammation and wound healing after orthopedic surgery: a randomized, placebo and active controlled clinical study.

2. Sci Rep. 2025 Oct 2;15(1):34336. doi: 10.1038/s41598-025-16747-2. Systemic enzyme therapy for postoperative inflammation and wound healing after orthopedic surgery: a randomized, placebo and active controlled clinical study. Suryawanshi A(1), Patkar H(2), Aute S(3), Rathi PC(4), Rathi CL(4), R

Efficacy and safety of Atusin(®) CAP in the treatment of acute uncomplicated bronchitis in the primary care setting: a multi-center, randomized, double-blind, placebo-controlled study (AABA).

3. BMC Pulm Med. 2025 Oct 1;25(1):443. doi: 10.1186/s12890-025-03912-6. Efficacy and safety of Atusin(®) CAP in the treatment of acute uncomplicated bronchitis in the primary care setting: a multi-center, randomized, double-blind, placebo-controlled study (AABA). Petkova D(1), Petkov R(2), Hodzh

Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.

4. RMD Open. 2025 Aug 12;11(3):e005433. doi: 10.1136/rmdopen-2025-005433. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial. Henrotin Y(#)(1), Pap T(#)(

The Correlation Between Wound Bed Preparation and Wound Closure in Venous Leg Ulcers: A Post Hoc Analysis of the ChronEx Multicenter Randomized Controlled Trial.

5. Adv Wound Care (New Rochelle). 2026 Jan;15(1):32-40. doi: 10.1177/21621918251366644. Epub 2025 Aug 13. The Correlation Between Wound Bed Preparation and Wound Closure in Venous Leg Ulcers: A Post Hoc Analysis of the ChronEx Multicenter Randomized Controlled Trial. Carter MJ(1), Snyder RJ(2)(

Bromelain-Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study.

6. Mol Nutr Food Res. 2025 Oct;69(19):e70148. doi: 10.1002/mnfr.70148. Epub 2025 Jun 19. Bromelain-Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study. Colletti A(1)(2), Sangiorgio L(3), Martelli A(2)(4), Pellizzato M(2), Cravo

Bromelain-based debridement versus collagenase ointment debridement of venous leg ulcers: post hoc analysis of the ChronEx trial.

7. Wounds. 2025 Apr;37(4):166-173. doi: 10.25270/wnds/24148. Bromelain-based debridement versus collagenase ointment debridement of venous leg ulcers: post hoc analysis of the ChronEx trial. Dove CR(1), Snyder RJ(2), Zarbiv KD(3), Levy YK(3), Haviv A(3), Klinger E(3), Shoham Y(4), Sigal F(5). A

Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial.

8. Clin Exp Dent Res. 2025 Apr;11(2):e70124. doi: 10.1002/cre2.70124. Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial. Ajami S(1), Hosseini SH(2), Babanouri N(1), Hashemi Z(3). Author inf

Open label randomized controlled trial of the efficacy and safety of NexoBrid compared to standard of care in children with burns.

9. Burns. 2025 May;51(4):107417. doi: 10.1016/j.burns.2025.107417. Epub 2025 Feb 5. Open label randomized controlled trial of the efficacy and safety of NexoBrid compared to standard of care in children with burns. Shoham Y(1), Rosenberg L(2), Narayan RP(3), Staubach R(4), Bene R(5), Kakola M(6)

COMBINED INTRAVITREAL AFLIBERCEPT AND ANTI-INFLAMMATORY ORAL SUPPLEMENTATION IN THE TREATMENT OF DIABETIC MACULAR EDEMA: Two-Year Randomized Controlled Trial Results.

10. Retina. 2025 Jun 1;45(6):1134-1142. doi: 10.1097/IAE.0000000000004427. COMBINED INTRAVITREAL AFLIBERCEPT AND ANTI-INFLAMMATORY ORAL SUPPLEMENTATION IN THE TREATMENT OF DIABETIC MACULAR EDEMA: Two-Year Randomized Controlled Trial Results. Marolo P(1), Volti GL(2), Nicolosi A(3), Avitabile T(4

Combined Treatment of Sodium Butyrate and Bromelain Enhanced Anticancer Effects in Colorectal Cancer Cell Lines: A Promising Therapeutic Approach.

11. Int J Mol Sci. 2025 Oct 8;26(19):9803. doi: 10.3390/ijms26199803. Combined Treatment of Sodium Butyrate and Bromelain Enhanced Anticancer Effects in Colorectal Cancer Cell Lines: A Promising Therapeutic Approach. Olivera-Salazar R(1), Villarejo Campos P(2), Barrueco Gutiérrez R(1), Vega-Clem

Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies.

12. Nutrients. 2024 Jun 14;16(12):1883. doi: 10.3390/nu16121883. Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies. Mecca M(1), Sichetti M(1), Giuseffi M(1), Giglio E(1), Sabato C(1), Sanseverino F(2), Marino G(3). Author information: (1)Lab

The vital role of animal, marine, and microbial natural products against COVID-19.

13. Pharm Biol. 2022 Dec;60(1):509-524. doi: 10.1080/13880209.2022.2039215. The vital role of animal, marine, and microbial natural products against COVID-19. Alqathama AA(1), Ahmad R(2), Alsaedi RB(1), Alghamdi RA(1), Abkar EH(1), Alrehaly RH(1), Abdalla AN(3). Author information: (1)Departmen

The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2.

14. Viruses. 2021 Mar 6;13(3):425. doi: 10.3390/v13030425. The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2. Akhter J(1)(2), Quéromès G(3), Pillai K(2), Kepenekian V(1)(4), Badar S(1)(5), Mekkawy AH(1)(2)(5), Frobert E(3)(6), Valle SJ(1)(2)(5), Morr

Cisplatin bioconjugated enzymatic GNPs amplify the effect of cisplatin with acquiescence.

15. Sci Rep. 2019 Sep 25;9(1):13826. doi: 10.1038/s41598-019-50215-y. Cisplatin bioconjugated enzymatic GNPs amplify the effect of cisplatin with acquiescence. Iram S(1), Zahera M(1), Wahid I(1), Baker A(1), Raish M(2), Khan A(3), Ali N(4), Ahmad S(1), Khan MS(5). Author information: (1)Nanomed

Combination of essential oil and ciprofloxacin to inhibit/eradicate biofilms in multidrug-resistant Klebsiella pneumoniae.

40. J Appl Microbiol. 2018 Jul;125(1):84-95. doi: 10.1111/jam.13755. Epub 2018 Apr 19. Combination of essential oil and ciprofloxacin to inhibit/eradicate biofilms in multidrug-resistant Klebsiella pneumoniae. Mohamed SH(1), Mohamed MSM(2), Khalil MS(2), Azmy M(3), Mabrouk MI(1). Author informa

Antibacterial activity of papain and bromelain on Alicyclobacillus spp.

45. Int J Food Microbiol. 2016 Jan 4;216:121-6. doi: 10.1016/j.ijfoodmicro.2015.10.007. Epub 2015 Oct 8. Antibacterial activity of papain and bromelain on Alicyclobacillus spp. dos Anjos MM(1), da Silva AA(1), de Pascoli IC(1), Mikcha JM(2), Machinski M Jr(3), Peralta RM(4), de Abreu Filho BA(5)

Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy.

15. J Exp Clin Cancer Res. 2014 Nov 12;33(1):92. doi: 10.1186/s13046-014-0092-7. Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy. Amini A(1), Masoumi-Moghaddam S, Ehteda A, Morris DL. Author informat

Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells.

49. Anticancer Drugs. 2014 Feb;25(2):150-60. doi: 10.1097/CAD.0000000000000039. Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells. Pillai K(1), Ehteda A, Akhter J, Chua TC, Morris DL. Author information: (1)Department of Surgery, Univers

Complementary therapies, herbs, and other OTC agents. Bromelain.

45. Oncology (Williston Park). 2011 Feb;25(2):195. Complementary therapies, herbs, and other OTC agents. Bromelain. Cassileth B(1). Author information: (1)Memorial Sloan-Kettering Cancer Center, New York, New York, USA. PMID: 21456393 [Indexed for MEDLINE]

Histopathological Changes Following Bromelain-Based Enzymatic Debridement (NexoBrid(®)): A Comprehensive Systematic Review of Preclinical and Clinical Evidence.

2. Med Sci (Basel). 2026 Mar 23;14(1):157. doi: 10.3390/medsci14010157. Histopathological Changes Following Bromelain-Based Enzymatic Debridement (NexoBrid(®)): A Comprehensive Systematic Review of Preclinical and Clinical Evidence. Avadanei-Luca S(1)(2), Moraru DC(1)(2), Bulgaru-Iliescu AI(1)(2

Efficacy and Safety of Bromelain-Based Enzymatic Debridement for Chronic Wounds: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

31. Wound Repair Regen. 2026 Jan-Feb;34(1):e70132. doi: 10.1111/wrr.70132. Efficacy and Safety of Bromelain-Based Enzymatic Debridement for Chronic Wounds: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Günay UB(1), Tanin MK(1), Demiröz A(2). Author information: (1)Cerrah

Interventions for reducing bleeding and swelling in eyelid and periocular surgeries: a systematic review of randomized controlled trials.

30. Orbit. 2025 Dec;44(6):913-927. doi: 10.1080/01676830.2025.2581622. Epub 2025 Nov 20. Interventions for reducing bleeding and swelling in eyelid and periocular surgeries: a systematic review of randomized controlled trials. Alamoudi A(1)(2), Albishry AM(1)(2)(3), Alnabihi AN(2), Batais WT(2),

Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action.

9. J Pharm Pharmacol. 2025 Jul 1;77(7):884-896. doi: 10.1093/jpp/rgaf021. Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action. Mohammed JS(1), Ahmed AT(2), Singh M(3), Hanumanthayya M(4), Kazmi SW(5), Chahar M(6), Kareem Al-H

Supplementation Containing Bromelain on the Side Effects of Oncological Treatment: Systematic Review.

26. J Med Food. 2025 Jun;28(6):513-518. doi: 10.1089/jmf.2023.0027. Epub 2025 May 15. Supplementation Containing Bromelain on the Side Effects of Oncological Treatment: Systematic Review. Pereira IC(1), Passos RB(1), Viana CMC(1), Mascarenhas IF(1), Nascimento GTM(2), Silva FCCD(2), Sousa JMCE(

The role of Bromelain and Liposomal Vitamin C in the treatment of chronic venous disease.

38. Vasa. 2025 May;54(3):164-176. doi: 10.1024/0301-1526/a001184. Epub 2025 Feb 19. The role of Bromelain and Liposomal Vitamin C in the treatment of chronic venous disease. Buso G(1)(2), Santini P(3)(4), Ghirardini F(5), Cannavacciuolo F(6), Visonà A(7), Zalunardo B(8), Pola R(3)(4), Martini R(

Bromelain and liver health: A comprehensive systematic review of preclinical studies.

9. Clin Nutr ESPEN. 2025 Apr;66:437-445. doi: 10.1016/j.clnesp.2025.02.001. Epub 2025 Feb 11. Bromelain and liver health: A comprehensive systematic review of preclinical studies. Pereira IC(1), Pedrosa-Santos ÁMC(2), Martins JA(1), Sousa AA(3), Nobre TA(3), Torres LRO(4), Silva FCCD(5), Severo

Bromelain-Based Enzymatic Debridement Versus Standard of Care in Deep Burn Injuries: A Systematic Review and Meta-Analysis.

33. J Burn Care Res. 2025 Jan 24;46(1):123-131. doi: 10.1093/jbcr/irae172. Bromelain-Based Enzymatic Debridement Versus Standard of Care in Deep Burn Injuries: A Systematic Review and Meta-Analysis. De Freitas LR(1), Udoma-Udofa OC(1), Reginato PH(2), Mitsui HC(1), Provinciatto H(3), Torres FC(4

Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms.

34. Nutrients. 2024 Jun 28;16(13):2060. doi: 10.3390/nu16132060. Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms. Kansakar U(1), Trimarco V(2), Manzi MV(3), Cervi E(4), Mone P(1)(5)(6), Santulli G(1)(3)(7). Author information: (1)Department of Medicine,

Bromelain as a natural anti-inflammatory drug: a systematic review.

5. Nat Prod Res. 2025 Mar;39(5):1258-1271. doi: 10.1080/14786419.2024.2342553. Epub 2024 Apr 27. Bromelain as a natural anti-inflammatory drug: a systematic review. Alves Nobre T(1), de Sousa AA(1), Pereira IC(2), Carvalho Pedrosa-Santos ÁM(2), Lopes LO(1), Debia N(2), El-Nashar HAS(3), El-Shazl