콜라겐 II형 (관절)

Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.

1. Br J Sports Med. 2018 Feb;52(3):167-175. doi: 10.1136/bjsports-2016-097333. Epub 2017 Oct 10. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Liu X(1)(2), Machado GC(3), Eyles JP(1)(2)(4), Ravi V(1)(2), Hunter DJ(1)(2). Author information: (1)Departmen

The Biological Effect of Platelet-Rich Plasma on Subacromial Bursa and Torn Supraspinatus Tendon: A Randomized Controlled Trial.

2. Int J Mol Sci. 2026 Mar 26;27(7):3002. doi: 10.3390/ijms27073002. The Biological Effect of Platelet-Rich Plasma on Subacromial Bursa and Torn Supraspinatus Tendon: A Randomized Controlled Trial. Pitsilos C(1), Fragou A(2), Karachrysafi S(3)(4), Gigis I(1), Ditsios K(1), Chalidis B(5). Author

Acute effect of impact and resistance exercise on Wnt signaling modulators, bone and cartilage metabolism.

3. J Bone Miner Res. 2026 Mar 2;41(3):282-292. doi: 10.1093/jbmr/zjaf128. Acute effect of impact and resistance exercise on Wnt signaling modulators, bone and cartilage metabolism. Boxer B(1)(2), Zhang Z(1), Folland JP(1)(2)(3), Eastell R(4), Gossiel F(4), Caliskan O(1)(2)(5), Brooke-Wavell K(1)

Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study.

4. Sci Rep. 2025 Jul 15;15(1):25625. doi: 10.1038/s41598-025-11723-2. Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study. Fladerer-Grollitsch JP(1)(2), Klein T(3), Kom

[Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].

5. Ter Arkh. 2025 Feb 21;97(1):54-64. doi: 10.26442/00403660.2025.01.203145. [Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial]. [Article in Russian; Abstract ava

Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Double-blind, Multicenter, Placebo-Controlled Clinical Trial.

6. Pharm Res. 2025 Feb;42(2):249-269. doi: 10.1007/s11095-025-03818-2. Epub 2025 Jan 28. Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Double-blind, Multicenter, Placebo-Controlled Clinical Trial. V

The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study.

7. BMC Musculoskelet Disord. 2025 Jan 4;26(1):17. doi: 10.1186/s12891-024-08244-w. The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, plac

Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study.

8. Jt Dis Relat Surg. 2025 Jan 2;36(1):85-96. doi: 10.52312/jdrs.2025.1965. Epub 2024 Nov 5. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placeb

A Standardized Boswellia serrata Extract Improves Knee Joint Function and Cartilage Morphology in Human Volunteers with Mild to Moderate Osteoarthritis in a Randomized Placebo-Controlled Study.

9. J Am Nutr Assoc. 2025 Jul;44(5):375-386. doi: 10.1080/27697061.2024.2438894. Epub 2024 Dec 19. A Standardized Boswellia serrata Extract Improves Knee Joint Function and Cartilage Morphology in Human Volunteers with Mild to Moderate Osteoarthritis in a Randomized Placebo-Controlled Study. Kum

[Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].

10. Ter Arkh. 2024 Jun 3;96(5):500-509. doi: 10.26442/00403660.2024.05.202788. [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial]. [Article in Russian; Abstract available in Ru

[Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D(3) and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee joint].

11. Ter Arkh. 2023 Dec 28;95(12):1141-1150. doi: 10.26442/00403660.2023.12.202540. [Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D(3) and a combination of chondroitin sulfate and glucosamine hydrochloride in the trea

Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis.

12. Sci Rep. 2021 Jul 19;11(1):14724. doi: 10.1038/s41598-021-94142-3. Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis. Sahin K(1), Kucuk O(2), Orhan C(3), Tuzcu M(4), Durmus AS(5), Ozercan IH(6), Sahin N(3), Ju

The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis.

13. Minerva Med. 2019 Oct;110(5):419-424. doi: 10.23736/S0026-4806.19.06063-4. Epub 2019 Apr 1. The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis. Korotkyi OH(1), Vovk

The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis.

14. Lab Invest. 2018 Dec;98(12):1600-1613. doi: 10.1038/s41374-018-0127-3. Epub 2018 Sep 11. The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis. Wang Z(1)(2), Li J(3), Xiao W(3), Long J(4)(5), Zhang H(6). Author information: (1)College of Life Sciences, Nanka

Intra-Articular Injection of Cross-Linked Hyaluronic Acid-Dexamethasone Hydrogel Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis.

15. Int J Mol Sci. 2016 Apr 15;17(4):411. doi: 10.3390/ijms17040411. Intra-Articular Injection of Cross-Linked Hyaluronic Acid-Dexamethasone Hydrogel Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis. Zhang Z(1), Wei X(2), Gao J(3), Zhao Y(4), Zhao Y(5), Guo L(6),

Blockade of interleukin-6 receptor enhances the anti-arthritic effect of glucocorticoids without decreasing bone mineral density in mice with collagen-induced arthritis.

40. Clin Exp Immunol. 2015 Nov;182(2):154-61. doi: 10.1111/cei.12685. Epub 2015 Aug 31. Blockade of interleukin-6 receptor enhances the anti-arthritic effect of glucocorticoids without decreasing bone mineral density in mice with collagen-induced arthritis. Suzuki M(1), Yoshida H(1), Hashizume

Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis.

37. PLoS One. 2014 Nov 6;9(11):e111843. doi: 10.1371/journal.pone.0111843. eCollection 2014. Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis. Al-Abd AM(1), Al-Abbasi FA(2), Nofal SM(3), Khalifa AE(4), Williams RO(5), El-Eraky WI(3),

A combination of sinomenine and methotrexate reduces joint damage of collagen induced arthritis in rats by modulating osteoclast-related cytokines.

8. Int Immunopharmacol. 2014 Jan;18(1):135-41. doi: 10.1016/j.intimp.2013.11.014. Epub 2013 Nov 25. A combination of sinomenine and methotrexate reduces joint damage of collagen induced arthritis in rats by modulating osteoclast-related cytokines. Sun Y(1), Yao Y(2), Ding CZ(3). Author informat

Nimesulide improves the disease modifying anti-rheumatic profile of methotrexate in mice with collagen-induced arthritis.

5. Eur J Pharmacol. 2010 Oct 10;644(1-3):245-50. doi: 10.1016/j.ejphar.2010.07.006. Epub 2010 Jul 16. Nimesulide improves the disease modifying anti-rheumatic profile of methotrexate in mice with collagen-induced arthritis. Al-Abd AM(1), Inglis JJ, Nofal SM, Khalifa AE, Williams RO, El-Eraky WI,

Synergistic attenuation of myocardial fibrosis in spontaneously hypertensive rats by joint treatment with benazepril and candesartan.

31. J Cardiovasc Pharmacol. 2009 Jul;54(1):16-24. doi: 10.1097/FJC.0b013e3181a98b31. Synergistic attenuation of myocardial fibrosis in spontaneously hypertensive rats by joint treatment with benazepril and candesartan. Meng G(1), Wu F, Yang L, Zhu H, Gu J, He M, Xu J. Author information: (1)Depa

Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis.

10. Arthritis Rheum. 2009 Feb;60(2):513-23. doi: 10.1002/art.24258. Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis. Li X(1), Ellman M, Muddasani P, Wang JH, Cs-Szabo G, van Wijnen AJ, Im HJ.

A clinical pilot study to evaluate the efficacy of oral intake of phellinus linteus (sanghuang) extract on knee joint and articular cartilage: Study protocol clinical trial (SPIRIT Compliant).

25. Medicine (Baltimore). 2020 Feb;99(8):e18912. doi: 10.1097/MD.0000000000018912. A clinical pilot study to evaluate the efficacy of oral intake of phellinus linteus (sanghuang) extract on knee joint and articular cartilage: Study protocol clinical trial (SPIRIT Compliant). Ku YH(1), Lee H(1),

Carrageenan-based hydrogels and composite scaffolds for cartilage and osteochondral regeneration: Mechanisms, performance, and future perspectives.

35. Int J Biol Macromol. 2026 Mar;351:151049. doi: 10.1016/j.ijbiomac.2026.151049. Epub 2026 Feb 21. Carrageenan-based hydrogels and composite scaffolds for cartilage and osteochondral regeneration: Mechanisms, performance, and future perspectives. Talouki PY(1), Tamimi R(2), Mahmoodi M(3). Aut

Therapeutic effects and mechanisms of Tripterygium wilfordii extracts in rheumatoid arthritis: a systematic review and meta-analysis of preclinical studies.

47. Sci Rep. 2025 Jul 31;15(1):27960. doi: 10.1038/s41598-025-13241-7. Therapeutic effects and mechanisms of Tripterygium wilfordii extracts in rheumatoid arthritis: a systematic review and meta-analysis of preclinical studies. Chen K(#)(1), Chen X(#)(1), Huang S(1), Zhou L(2), Zhou X(1), Lu Y(3

The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies.

35. Front Biosci (Landmark Ed). 2025 Jun 25;30(6):38302. doi: 10.31083/FBL38302. The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies. Wang B(1), Xie D(1), Huang J(1), Huang Z(1), Weng W(1), Huang

Preclinical Use of FGF-18 Augmentation for Improving Cartilage Healing Following Surgical Repair: A Systematic Review.

18. Cartilage. 2023 Mar;14(1):59-66. doi: 10.1177/19476035221142010. Epub 2022 Dec 21. Preclinical Use of FGF-18 Augmentation for Improving Cartilage Healing Following Surgical Repair: A Systematic Review. DePhillipo NN(1)(2), Hendesi H(3), Aman ZS(4), Lind DRG(1), Smith J(5), Dodge GR(1)(2).

Blosozumab in the treatment of postmenopausal women with osteoporosis: a systematic review and meta-analysis.

38. Ann Palliat Med. 2022 Oct;11(10):3203-3212. doi: 10.21037/apm-22-998. Blosozumab in the treatment of postmenopausal women with osteoporosis: a systematic review and meta-analysis. Su Y(1), Wang W(2), Liu F(3), Cai Y(4), Li N(4), Li H(5), Li G(4), Ma L(6). Author information: (1)Department of

Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review.

42. Int J Rheum Dis. 2022 Sep;25(9):973-981. doi: 10.1111/1756-185X.14382. Epub 2022 Jul 5. Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review. Jabbari M(1), Barati M(2), Khodaei M(3), Babashahi M(4), Kalhori A(5), Tahmassian

Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review.

46. Cartilage. 2021 Dec;13(1_suppl):1511S-1531S. doi: 10.1177/1947603520941239. Epub 2020 Jul 17. Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review. Convill JG(1), Tawy GF(1), Freemont AJ(1), Biant LC(1). Author information: (1)Faculty of Biology

Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

27. Arthritis Care Res (Hoboken). 2019 Nov;71(11):1504-1515. doi: 10.1002/acr.23786. Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Co