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Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

1. Nutrients. 2022 Jul 9;14(14):2831. doi: 10.3390/nu14142831. Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Wei J(1), Yan J(1), Yang H(1). Author information: (1)Department of Obst

Inositol for the prevention of gestational diabetes: a systematic review and meta-analysis of randomized controlled trials.

2. Arch Gynecol Obstet. 2019 Jan;299(1):55-68. doi: 10.1007/s00404-018-5005-0. Epub 2018 Dec 18. Inositol for the prevention of gestational diabetes: a systematic review and meta-analysis of randomized controlled trials. Vitagliano A(1), Saccone G(2), Cosmi E(3), Visentin S(3), Dessole F(4), Am

Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials.

3. Arch Gynecol Obstet. 2018 Oct;298(4):675-684. doi: 10.1007/s00404-018-4861-y. Epub 2018 Aug 4. Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials. La

Inositol supplementation in women with polycystic ovary syndrome undergoing intracytoplasmic sperm injection: a systematic review and meta-analysis of randomized controlled trials.

4. Reprod Biomed Online. 2017 Nov;35(5):529-535. doi: 10.1016/j.rbmo.2017.07.005. Epub 2017 Jul 14. Inositol supplementation in women with polycystic ovary syndrome undergoing intracytoplasmic sperm injection: a systematic review and meta-analysis of randomized controlled trials. Mendoza N(1),

Antioxidants for female subfertility.

5. Cochrane Database Syst Rev. 2017 Jul 28;7(7):CD007807. doi: 10.1002/14651858.CD007807.pub3. Antioxidants for female subfertility. Showell MG(1), Mackenzie-Proctor R, Jordan V, Hart RJ. Author information: (1)Department of Obstetrics and Gynaecology, University of Auckland, Park Road Grafton,

Inositol's and other nutraceuticals' synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state-of-the-art and future perspectives.

6. Gynecol Endocrinol. 2016 Jun;32(6):431-8. doi: 10.3109/09513590.2016.1144741. Epub 2016 Feb 29. Inositol's and other nutraceuticals' synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state-of-the-art and future perspectives. Paul C(1), L

Effect of 40:1 myo-inositol/D-chiro-inositol treatment on serum asprosin levels in polycystic ovary syndrome: a prospective randomized pilot study.

7. Ginekol Pol. 2025;96(11):925-931. doi: 10.5603/gpl.103763. Epub 2025 Jul 16. Effect of 40:1 myo-inositol/D-chiro-inositol treatment on serum asprosin levels in polycystic ovary syndrome: a prospective randomized pilot study. Ozay OE(1), Ozay Y(2), Edebal O(3), Calcagno M(4), Ozay AC(5)(6). Au

Comparative efficacy of combined myo-inositol and D-chiro inositol versus metformin across PCOS Phenotypes: enhancing ovarian function, ovulation, and stress response in a prospective clinical trial.

8. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul;398(7):8761-8772. doi: 10.1007/s00210-025-03813-9. Epub 2025 Jan 23. Comparative efficacy of combined myo-inositol and D-chiro inositol versus metformin across PCOS Phenotypes: enhancing ovarian function, ovulation, and stress response in a prospe

Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Cinnamomum zeylanicum Blume and Inulin in Patients with Metabolic Syndrome.

9. Nutrients. 2024 Jan 12;16(2):249. doi: 10.3390/nu16020249. Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Cinnamomum zeylanicum Blume and Inulin in Patients with Metabolic Syndrome. Citarrella R(1), Chianetta R(1), Amodeo S(1), Mirarchi L(2), Licata A(1), Soresi M(

A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome.

10. Clin Endocrinol (Oxf). 2023 Aug;99(2):198-205. doi: 10.1111/cen.14931. Epub 2023 Jun 2. A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome. Nazirudeen R(1), Sridhar S(1), Priyanka R(1), Sumathi B(2), Natarajan V(1), S

Efficacy of myo-inositol and d-chiro-inositol combination on menstrual cycle regulation and improving insulin resistance in young women with polycystic ovary syndrome: A randomized open-label study.

11. Int J Gynaecol Obstet. 2022 Aug;158(2):278-284. doi: 10.1002/ijgo.13971. Epub 2021 Nov 10. Efficacy of myo-inositol and d-chiro-inositol combination on menstrual cycle regulation and improving insulin resistance in young women with polycystic ovary syndrome: A randomized open-label study. K

Risk of reduced intestinal absorption of myo-inositol caused by D-chiro-inositol or by glucose transporter inhibitors.

12. Expert Opin Drug Metab Toxicol. 2019 Sep;15(9):697-703. doi: 10.1080/17425255.2019.1651839. Epub 2019 Aug 8. Risk of reduced intestinal absorption of myo-inositol caused by D-chiro-inositol or by glucose transporter inhibitors. Garzon S(1), Laganà AS(1), Monastra G(2). Author information: (

Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.

13. Biochemistry. 2005 Aug 23;44(33):11067-73. doi: 10.1021/bi0508845. Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action. Brautigan DL(1), Brown M, Grindrod S, Chinigo G, Kruszewski A, Lukasik SM, Bushweller JH, Horal

D-chiro-Inositol enhances effects of hypothalamic toxin gold-thioglucose.

14. Brain Res. 2003 Dec 12;993(1-2):172-6. doi: 10.1016/j.brainres.2003.09.008. D-chiro-Inositol enhances effects of hypothalamic toxin gold-thioglucose. Isoda F(1), Shiry L, Abergel J, Allan G, Mobbs C. Author information: (1)Neurobiology of Aging Laboratories, Fishberg Center for Neurobiology,

Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.

15. Front Endocrinol (Lausanne). 2026 Feb 11;17:1741509. doi: 10.3389/fendo.2026.1741509. eCollection 2026. Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials. Duan M(1)(2), Yang M(1)(2), Li C(1)(2), Wu X(1)(2), Yin

Comparison of metformin with inositol versus metformin alone in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

50. Endocrine. 2025 Feb;87(2):389-399. doi: 10.1007/s12020-024-04052-3. Epub 2024 Sep 27. Comparison of metformin with inositol versus metformin alone in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Kelly FA(1), de Oliveira Macena

Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines.

35. J Clin Endocrinol Metab. 2024 May 17;109(6):1630-1655. doi: 10.1210/clinem/dgad762. Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines. Fitz V(1), Graca S(2), Mahalingaiah S(1), Liu J(3),

Myoinositol or D-chiro-inositol for PCOS symptoms in adolescents: a narrative review.

16. J Pediatr Endocrinol Metab. 2023 Dec 21;37(2):91-101. doi: 10.1515/jpem-2023-0458. Print 2024 Feb 26. Myoinositol or D-chiro-inositol for PCOS symptoms in adolescents: a narrative review. Sairally BZF(1), Dhillon-Smith RK(1), Jethwani G(1), Latthe P(1). Author information: (1)Birmingham Wom

Exploring strengths and limits of urinary D-chiro inositol phosphoglycans (IPG-P) as a screening test for preeclampsia: A systematic review and meta-analysis.

36. J Reprod Immunol. 2019 Sep;134-135:21-27. doi: 10.1016/j.jri.2019.07.005. Epub 2019 Jul 26. Exploring strengths and limits of urinary D-chiro inositol phosphoglycans (IPG-P) as a screening test for preeclampsia: A systematic review and meta-analysis. Scioscia M(1), Noventa M(2), Cavallin F(

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

6. Cochrane Database Syst Rev. 2017 Nov 29;11(11):CD003053. doi: 10.1002/14651858.CD003053.pub6. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Morley LC(1), Tang T, Yasmin E, Nor

Effect of inositol and its derivatives on diabetes: a systematic review.

31. Crit Rev Food Sci Nutr. 2019;59(7):1124-1136. doi: 10.1080/10408398.2017.1392926. Epub 2019 Jan 12. Effect of inositol and its derivatives on diabetes: a systematic review. Özturan A(1), Arslan S(1), Kocaadam B(1), Elibol E(2), İmamoğlu İ(3), Karadağ MG(1). Author information: (1)a Faculty