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Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies.

1. Food Chem. 2025 Jun 15;477:143630. doi: 10.1016/j.foodchem.2025.143630. Epub 2025 Feb 26. Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies. Liu L(1), Barber E(1), Kellow NJ(2), Williamson G(3). Author information: (1)Department of Nutri

Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis.

2. Phytother Res. 2023 May;37(5):2092-2101. doi: 10.1002/ptr.7817. Epub 2023 Mar 29. Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis. Correia AGDS(1), Alencar MB(1), Dos Santos AN(1), da Paixão DCB(1), Sandes FLF(1), Andrade B(1), Castro Y(2), d

The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

3. High Blood Press Cardiovasc Prev. 2023 Mar;30(2):123-133. doi: 10.1007/s40292-023-00565-6. Epub 2023 Feb 10. The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Amini MR(1), Payandeh N(2), Sheikhhossein F(3), Pour

Effects of fenugreek supplementation on the components of metabolic syndrome: A systematic review and dose-response meta-analysis of randomized clinical trials.

4. Pharmacol Res. 2023 Jan;187:106594. doi: 10.1016/j.phrs.2022.106594. Epub 2022 Dec 5. Effects of fenugreek supplementation on the components of metabolic syndrome: A systematic review and dose-response meta-analysis of randomized clinical trials. Fakhr L(1), Chehregosha F(1), Zarezadeh M(1),

Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants.

5. Cochrane Database Syst Rev. 2020 May 18;5(5):CD011505. doi: 10.1002/14651858.CD011505.pub2. Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants. Foong SC(1), Tan ML(1), Foong WC(1), Marasco LA(2), Ho JJ(1), Ong JH(3

Effect of fenugreek consumption on serum lipid profile: A systematic review and meta-analysis.

6. Phytother Res. 2020 Sep;34(9):2230-2245. doi: 10.1002/ptr.6690. Epub 2020 May 8. Effect of fenugreek consumption on serum lipid profile: A systematic review and meta-analysis. Heshmat-Ghahdarijani K(1), Mashayekhiasl N(2), Amerizadeh A(3), Teimouri Jervekani Z(4), Sadeghi M(5). Author inform

Effect of fenugreek supplementation on blood lipids and body weight: A systematic review and meta-analysis of randomized controlled trials.

7. J Ethnopharmacol. 2020 May 10;253:112538. doi: 10.1016/j.jep.2019.112538. Epub 2020 Feb 20. Effect of fenugreek supplementation on blood lipids and body weight: A systematic review and meta-analysis of randomized controlled trials. Askarpour M(1), Alami F(2), Campbell MS(3), Venkatakrishnan K

Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials.

8. Phytother Res. 2020 Jul;34(7):1550-1555. doi: 10.1002/ptr.6627. Epub 2020 Feb 11. Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials. Mansoori A(1), Hosseini S(1)(2), Zilaee M(1)(2), Hormoznejad R(3), Fathi M(3). Author information: (1)N

Dietary supplements for dysmenorrhoea.

9. Cochrane Database Syst Rev. 2016 Mar 22;3(3):CD002124. doi: 10.1002/14651858.CD002124.pub2. Dietary supplements for dysmenorrhoea. Pattanittum P(1), Kunyanone N, Brown J, Sangkomkamhang US, Barnes J, Seyfoddin V, Marjoribanks J. Author information: (1)Department of Biostatistics and Demograp

Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes.

10. J Ethnopharmacol. 2011 Oct 11;137(3):1328-33. doi: 10.1016/j.jep.2011.07.059. Epub 2011 Aug 5. Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes. Suksomboon N(1), Poolsup N, Boonkaew S, Suthisisang CC. Author information: (1)Department of Pharmacy, Facu

Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial.

11. Curr Drug Res Rev. 2025;17(3):471-480. doi: 10.2174/0125899775313919240822102906. Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial. Rouhi M(1), Hossieni MB(2), Khodai

Effect of 'FenuflakesTM' on 24-hour glycemic variability in adults with type 2 diabetes: A randomized crossover continuous glucose monitoring study.

12. Asia Pac J Clin Nutr. 2025 Oct;34(5):730-739. doi: 10.6133/apjcn.202510_34(5).0003. Effect of 'FenuflakesTM' on 24-hour glycemic variability in adults with type 2 diabetes: A randomized crossover continuous glucose monitoring study. Deshpande PO(1), Gokhale CA(2), Bhaskaran S(2), Gayathri R(

Effectiveness of Fenugreek as an Adjuvant in the Management of Oral Potentially Malignant Disorders: A Randomized Controlled Trial.

13. J Contemp Dent Pract. 2024 Oct 1;25(10):921-929. doi: 10.5005/jp-journals-10024-3773. Effectiveness of Fenugreek as an Adjuvant in the Management of Oral Potentially Malignant Disorders: A Randomized Controlled Trial. Balasundaram N(1), Narayanan MA(2), Antony LSA(3), Kumar SR(4), Anandan S(

Pharmacokinetics of a Natural Self-emulsifying Reversible Hybrid-Hydrogel (N'SERH) Formulation of Full-Spectrum Boswellia serrata Oleo-Gum Resin Extract: Randomised Double-Blinded Placebo-Controlled Crossover Study.

14. Biol Pharm Bull. 2024;47(9):1583-1593. doi: 10.1248/bpb.b24-00306. Pharmacokinetics of a Natural Self-emulsifying Reversible Hybrid-Hydrogel (N'SERH) Formulation of Full-Spectrum Boswellia serrata Oleo-Gum Resin Extract: Randomised Double-Blinded Placebo-Controlled Crossover Study. Joseph A(

Effect of a plant extract of fenugreek (Trigonella foenum-graecum) on testosterone in blood plasma and saliva in a double blind randomized controlled intervention study.

15. PLoS One. 2024 Sep 17;19(9):e0310170. doi: 10.1371/journal.pone.0310170. eCollection 2024. Effect of a plant extract of fenugreek (Trigonella foenum-graecum) on testosterone in blood plasma and saliva in a double blind randomized controlled intervention study. Lee-Ødegård S(1), Gundersen TE

A Placebo-Controlled, Double-Blind Clinical Investigation to Evaluate the Efficacy of a Patented Trigonella foenum-graecum Seed Extract "Fenfuro®" in Type 2 Diabetics.

13. J Am Nutr Assoc. 2024 Feb;43(2):147-156. doi: 10.1080/27697061.2023.2233008. Epub 2023 Jul 17. A Placebo-Controlled, Double-Blind Clinical Investigation to Evaluate the Efficacy of a Patented Trigonella foenum-graecum Seed Extract "Fenfuro®" in Type 2 Diabetics. Hota D(1), Padhy BM(1), Mait

Effectiveness of lactation cookies on human milk production rates: a randomized controlled trial.

28. Am J Clin Nutr. 2023 May;117(5):1035-1042. doi: 10.1016/j.ajcnut.2023.03.010. Epub 2023 Mar 14. Effectiveness of lactation cookies on human milk production rates: a randomized controlled trial. Palacios AM(1), Cardel MI(2), Parker E(3), Dickinson S(3), Houin VR(3), Young B(4), Allison DB(5)

Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study.

47. J Nutr Sci. 2022 Sep 9;11:e74. doi: 10.1017/jns.2022.72. eCollection 2022. Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study. Krishnakumar IM(1),

The effects of fenugreek seed extract supplementation in patients with Alzheimer's disease: A randomized, double-blind, placebo-controlled trial.

28. Phytother Res. 2023 Jan;37(1):285-294. doi: 10.1002/ptr.7612. Epub 2022 Oct 5. The effects of fenugreek seed extract supplementation in patients with Alzheimer's disease: A randomized, double-blind, placebo-controlled trial. Foroumandi E(1)(2), Javan R(3), Moayed L(4), Fahimi H(5), Kheirabadi

Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model.

38. Curr Drug Metab. 2021;22(12):969-977. doi: 10.2174/1389200222666211029152151. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Alkharfy K(1), Jan B(1), Alotaibi K(1), Alotaibi A(1), Alqahtani S(1), Raish M(2), Ahmad A(1). Author information: (1

Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension.

35. Pharm Biol. 2021 Dec;59(1):1088-1097. doi: 10.1080/13880209.2021.1961817. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Bin Jardan YA(1), Ahad A(1), Raish M(1), Alam MA(1), Al-Mohizea AM(1),

Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines.

50. Pharm Biol. 2021 Dec;59(1):424-437. doi: 10.1080/13880209.2021.1903047. Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines. Stefanowicz-Hajduk J(1), Król-Kogus B(2), Sparzak-Stefanowska

Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and Commercial Formulations of Twenty-Nine Herbal Supplements.

5. Drug Metab Dispos. 2020 Oct;48(10):1084-1091. doi: 10.1124/dmd.120.000033. Epub 2020 Jul 27. Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and C

Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.

38. Int J Biol Macromol. 2020 Oct 1;160:1242-1251. doi: 10.1016/j.ijbiomac.2020.05.220. Epub 2020 May 29. Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation. Deng Y(1), Yang X(1), Zhang X(1), C

Effect of Nigella sativa and Fenugreek on the Pharmacokinetics and Pharmacodynamics of Amlodipine in Hypertensive Rats.

17. Curr Drug Metab. 2020;21(4):318-325. doi: 10.2174/1389200221666200514121501. Effect of Nigella sativa and Fenugreek on the Pharmacokinetics and Pharmacodynamics of Amlodipine in Hypertensive Rats. Alam MA(1), Bin Jardan YA(1), Raish M(1), Al-Mohizea AM(1), Ahad A(1), Al-Jenoobi FI(1). Autho

Alleviation of Cardiac Damage by Dietary Fenugreek (Trigonella foenum-graecum) Seeds is Potentiated by Onion (Allium cepa) in Experimental Diabetic Rats via Blocking Renin-Angiotensin System.

16. Cardiovasc Toxicol. 2018 Jun;18(3):221-231. doi: 10.1007/s12012-017-9431-1. Alleviation of Cardiac Damage by Dietary Fenugreek (Trigonella foenum-graecum) Seeds is Potentiated by Onion (Allium cepa) in Experimental Diabetic Rats via Blocking Renin-Angiotensin System. Pradeep SR(1), Srinivasa

The Use of Complementary and Alternative Medicine in Hospitalized Patients with Type 2 Diabetes Mellitus in Israel.

45. J Altern Complement Med. 2015 Jul;21(7):395-400. doi: 10.1089/acm.2015.0019. Epub 2015 Jun 8. The Use of Complementary and Alternative Medicine in Hospitalized Patients with Type 2 Diabetes Mellitus in Israel. Koren R(1)(2), Lerner A(3), Tirosh A(2)(3), Zaidenstein R(1), Ziv-Baran T(2)(4),

Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs.

15. Pharm Biol. 2015 Feb;53(2):296-300. doi: 10.3109/13880209.2014.916312. Epub 2014 Sep 22. Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs. Al-Jenoobi FI(1), Ahad A, Mahrous GM, Al-Mohizea AM, AlKharfy KM, Al-Suwayeh SA. Author information: (

Natural products for the management of type 2 diabetes mellitus and comorbid conditions.

33. J Am Pharm Assoc (2003). 2014 Sep-Oct;54(5):e304-18; quiz e319-21. doi: 10.1331/JAPhA.2014.14537. Natural products for the management of type 2 diabetes mellitus and comorbid conditions. Smith JD, Clinard VB. OBJECTIVE: To provide pharmacists with practical information to guide consumers i

The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

7. Int J Mol Sci. 2023 Sep 12;24(18):13999. doi: 10.3390/ijms241813999. The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Kim J(1), Noh W(1), Kim A(1), Choi Y(2), Kim YS(3). Author information: (1)College of Korean