풀빅산
Fulvic Acid
📚 관련 논문 (13편)
1. Environ Toxicol Pharmacol. 2018 Dec;64:78-85. doi: 10.1016/j.etap.2018.09.010. Epub 2018 Sep 25. Algal toxicity of binary mixtures of zinc oxide nanoparticles and tetrabromobisphenol A: Roles of dissolved organic matters. Meng Y(1), Wang S(1), Wang Z(2), Ye N(1), Fang H(1). Author informatio
2. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018 Jun 7;53(7):651-658. doi: 10.1080/10934529.2018.1438814. Epub 2018 Feb 22. Dissolved organic matter and aluminum oxide nanoparticles synergistically cause cellular responses in freshwater microalgae. Ye N(1), Wang Z(1), Wang S(1), Fang
3. Environ Toxicol Chem. 2015 Apr;34(4):799-808. doi: 10.1002/etc.2787. Epub 2015 Feb 4. Acute toxicity of binary and ternary mixtures of Cd, Cu, and Zn to Daphnia magna. Meyer JS(1), Ranville JF, Pontasch M, Gorsuch JW, Adams WJ. Author information: (1)ARCADIS U.S., Lakewood, Colorado, USA; De
4. Environ Toxicol Chem. 2004 May;23(5):1248-55. doi: 10.1897/03-184. Effect of dissolved organic matter source on acute copper toxicity to Daphnia magna. De Schamphelaere KA(1), Vasconcelos FM, Tack FM, Allen HE, Janssen CR. Author information: (1)Laboratory of Environmental Toxicology and Aqua
5. Aquat Toxicol. 2003 May 8;63(3):221-8. doi: 10.1016/s0166-445x(02)00179-0. Accumulation, assimilation and growth inhibition of copper on freshwater alga (Scenedesmus subspicatus 86.81 SAG) in the presence of EDTA and fulvic acid. Ma M(1), Zhu W, Wang Z, Witkamp GJ. Author information: (1)SKLE
6. Chemosphere. 2000 Feb;40(3):319-25. doi: 10.1016/s0045-6535(99)00302-1. The effect of EDTA and fulvic acid on Cd, Zn, and Cu toxicity to a bioluminescent construct (pUCD607) of Escherichia coli. Campbell CD(1), Hird M, Lumsdon DG, Meeussen JC. Author information: (1)Soil Science Group, Macaul
7. Thromb Res. 1990 Jun 15;58(6):537-41. doi: 10.1016/0049-3848(90)90299-r. Arsenic as a promoter in the effect of humic substances on plasma prothrombin time in vitro. Lu FJ(1). Author information: (1)Department of Biochemistry, College of Medicine, National Taiwan University, Republic of Chin
8. Mutat Res. 1987 Feb;176(2):199-204. doi: 10.1016/0027-5107(87)90050-9. Mechanism of the desmutagenic effect of humic acid. Sato T, Ose Y, Nagase H, Hayase K. The mechanism of an apparent desmutagenic effect of humic acid was investigated. Firstly, components of humic acid (resorcinol, vanilli
1. Arch Med Res. 2012 Nov;43(8):699-704. doi: 10.1016/j.arcmed.2012.10.010. Epub 2012 Nov 3. Can nutraceuticals prevent Alzheimer's disease? Potential therapeutic role of a formulation containing shilajit and complex B vitamins. Carrasco-Gallardo C(1), Farías GA, Fuentes P, Crespo F, Maccioni RB. Author information: (1)International Center for Biomedicine, ICC, Santiago, Chile. carlosgabriel@live.cl Alzheimer's disease (AD) is a brain disorder displaying a prevalence and impact in constant expansion. This expansive and epidemic behavior is concerning medical and public opinion while focusing efforts on its prevention and treatment. One important strategy to prevent this brain impairment is based on dietary changes and nutritional supplements, functional foods and nutraceuticals. In this review we discuss the potential contributions of shilajit and complex B vitamins to AD prevention. We analyze the status of biological studies and present data of a clinical trial developed in patients with mild AD. Studies suggest that shilajit and its active principle fulvic acid, as well as a formula of shilajit with B complex vitamins, emerge as novel nutraceutical with potential uses against this brain disorder. Copyright © 2012 IMSS. Published by Elsevier Inc. All rights reserved. DOI: 10.1016/j.arcmed.2012.10.010 PMID: 23131823 [Indexed for MEDLINE]
2. J Anim Physiol Anim Nutr (Berl). 2025 May;109(3):834-843. doi: 10.1111/jpn.14100. Epub 2025 Jan 13. Effects of Feed Supplementation With Fulvic Acid on the Systemic and Mucosal Protective Mechanisms of Juvenile Rainbow Trout (Oncorhynchus mykiss). Zavvar F(1), Mazandarani M(1), Hoseinifar SH(1), Jafari V(1), Lieke T(2). Author information: (1)Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. (2)Faculty of Fisheries and Protection of Waters, South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses, Institute of Aquaculture and Protection of Waters, University of South Bohemia, České Budějovice, Czech Republic. Rainbow trout (Oncorhynchus mykiss) is an important fish species raised in aquaculture, but it is susceptible to stress, infections diseases. The present study aimed to determine the effects of fulvic acid feed addition on the systemic and mucosal protective mechanisms of juvenile rainbow trout and to elucidate the underlying molecular mechanisms of changes in the gut. Rainbow trout (4.30 ± 0.6 g) diet was supplemented with different levels of fulvic acid: 0% (Control), 0.5%, 1% and 2%. At the end of 8-week feeding trial, growth parameters such as final weight gained weight (%), SGR (F1%) increased, and FCR (all levels) decreased significantly compared to the control group. We found that the activity of lysozyme, glutathione peroxidase, and catalase in the serum were significantly improved, especially after the addition of 0.5% and 1% of fulvic acid. At the same time, the immunoglobulin concentration in the skin mucus was increased with 0.5% supplementation. However, the expression of tnf-α, il-6 and gpx in the intestine was strongly upregulated after supplementation with 2%, indicating oxidative stress and inflammation with this level of fulvic acid inclusion. Furthermore, the mucus lysozyme activity was reduced at this concentration, which can increase the susceptibility to pathogen invasion. The results suggest that adding 0.5%-1% of fulvic acid to the feed of juvenile rainbow trout can help to improve their immune and antioxidative defenses and thereby support the wellbeing of fish. © 2025 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd. DOI: 10.1111/jpn.14100 PMID: 39806798 [Indexed for MEDLINE]
3. Poult Sci. 2024 Feb;103(2):103273. doi: 10.1016/j.psj.2023.103273. Epub 2023 Nov 17. Effects of fulvic acid on broiler performance, blood biochemistry, and intestinal microflora. Liu L(1), Yang N(1), Chen Y(1), Xu Z(1), Zhang Q(1), Miao X(1), Zhao Y(1), Hu G(1), Liu L(2), Song Z(3), Li X(4). Author information: (1)College of Animal Science and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai'an, Shandong, China. (2)College of Life Science, Shandong Agricultural University, Tai'an, Shandong 271018, China. (3)Shandong Agricultural Fertilizer Technology Co., Ltd., Feicheng, Shandong 271600, China. (4)College of Animal Science and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai'an, Shandong, China; Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Tai'an 271018, China. Electronic address: xyli@sdau.edu.cn. To study the effects of mineral fulvic acid (FuA) on broiler performance, slaughter performance, blood biochemistry index, antioxidant function, immune performance, and intestinal microflora, 360 Arbor Acres (AA) broiler chickens with similar body weights were randomly divided into 5 groups with 6 replicates in each group and 12 chickens in each replicate in the current study. Chickens in the control group (C) were fed with the basal diet, and chickens in the test groups (I, II, III, and IV) were fed with the diet supplemented with 0.05%, 0.1%, 0.2%, and 0.3% mineral FuA, respectively. The indicators were measured on the hatching day, d 21 and d 35. From the whole experimental period, FuA supplement significantly increased average body weight (ABW) (P < 0.05), average daily gain (ADG) of broilers (P < 0.05), and thymus weight (P < 0.05) in II and IV groups, but bascially reduced the pH value of thigh meat. FuA supplement significantly improved aspartate aminotransferase (AST) activity in the group III on d 35 (P < 0.05) and the serum levels of IgA and IgG on d 21 and d 35 (P < 0.05), but reduced glutathione peroxidase (GSH-Px) level on d 21 (P < 0.05) and malondialdehyde (MDA) level in serum on d 35 (P < 0.05). FuA supplement significantly affected the abundance of Barnesiella, Lachnospiraceae, Alistipes, Lactobacillus, and Christensenellaceae on genus level. Differences between group III and other groups were significant in the genera microflora composition on d 21 and d 35. Functional analysis showed that the cecum microbiota were mainly enriched in carbohydrate metabolism, amino acid metabolism, and energy metabolism. In conclusion, FuA may potentially have significant positive effects on the growth performance and immune function of AA chickens through the modulation of the gut microbiota, and the 0.1% FuA was the best in broiler diet based on the present study. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. DOI: 10.1016/j.psj.2023.103273 PMCID: PMC10762468 PMID: 38096671 [Indexed for MEDLINE]
4. J Anim Sci. 2014 Aug;92(8):3624-35. doi: 10.2527/jas.2013-7436. Epub 2014 Jun 30. The effects of sodium sulfate in the water of nursery pigs and the efficacy of nonnutritive feed additives to mitigate those effects. Flohr JR(1), Tokach MD(1), Dritz SS(1), DeRouchey JM(1), Goodband RD(2), Nelssen JL(1). Author information: (1)Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506. (2)Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 goodband@ksu.edu. Two experiments were conducted to investigate the effects of sodium sulfate water and the efficacy of nonnutritive feed additives in nursery pig diets. In Exp. 1, 320 barrows (5.4 ± 0.1 kg BW and 21 d of age) were allotted to 1 of 8 treatments for 24 d in a 2 × 4 factorial with 2 levels of sodium sulfate water (control or 3,000 mg sodium sulfate/L added), and 4 dietary zeolite (clinoptilolite) levels (0, 0.25, 0.50, or 1%). Fecal samples were collected on d 5, 9, 16, and 23; visually scored for consistency (1 = firm and 5 = watery); and analyzed for DM. No interactions of sodium sulfate × zeolite were observed for any response criteria. Overall (d 0 to 24), pigs drinking sodium sulfate water had decreased (P < 0.01) ADG, ADFI, and G:F compared with pigs drinking control water. Pigs drinking sodium sulfate water also had increased (P < 0.01) fecal scores and lower (P < 0.04) fecal DM on d 5, 9, and 16 compared with pigs drinking control water. Increasing dietary zeolite increased (linear; P < 0.05) ADG and ADFI but had no effect on G:F. In Exp. 2, 350 barrows (5.7 ± 0.1 kg BW and 21 d of age) were allotted to 1 of 10 treatments in a 2 × 5 factorial for 21 d with 2 levels of sodium sulfate water (control or 2,000 mg sodium sulfate/L added) and 5 dietary treatments (control, 1 or 2% zeolite, 1% humic acid substance [HA], and 1% humic and fulvic acid substance [HFB]). Fecal samples were collected on d 5, 8, 15, and 21; visually scored for consistency (1 = firm and 5 = watery); and analyzed for DM. Overall (d 0 to 21), a water source × diet interaction was observed for ADG and G:F because pigs fed the 1% HA had decreased (P < 0.01) ADG and G:F when drinking sodium sulfate water compared with other treatments but increased ADG and G:F when drinking control water. Pigs drinking sodium sulfate water had decreased (P < 0.01) ADG and G:F and tended (P < 0.08) to have decreased ADFI compared with pigs drinking control water. Pigs drinking sodium sulfate water had increased (P < 0.01) fecal scores and decreased (P < 0.01) fecal DM on d 5 and 8. In conclusion, water high in sodium sulfate concentrations decreased growth performance and increased fecal moisture in newly weaned pigs. Although zeolite improved growth performance in the first experiment, it did not influence growth in the second study. The nonnutritive feed additives used in both experiments were unsuccessful in ameliorating the increased osmotic diarrhea observed from high sodium sulfate water. DOI: 10.2527/jas.2013-7436 PMID: 24981569 [Indexed for MEDLINE]
5. Aust Vet J. 2008 Jan-Feb;86(1-2):46-9. doi: 10.1111/j.1751-0813.2007.00242.x. Effects of a dietary complex of humic and fulvic acids (FeedMAX 15) on the health and production of feedlot cattle destined for the Australian domestic market. Cusack PM(1). Author information: (1)Australian Livestock Production Services, Cowra, NSW, Australia. pcusack@nexon.net.com OBJECTIVE: To examine the effects of a dietary humic and fulvic acid complex, FeedMAX 15, on the health, growth rate, feed conversion ratio, and carcase characteristics of feedlot cattle. DESIGN: Cattle, in eight pens of 125 animals each, were fed either a diet containing a humic and fulvic acid complex (FeedMAX 15, FeedMAX Industries, Toowoomba, Queensland) or the same diet without the additive. Control or FeedMAX 15 diets were allocated to each pen at random. Individual cattle were allocated alternately to control or treatment pens based on order of presentation. Comparisons of disease incidence, mortality, feed intake, growth rate, feed conversion ratio, fat depth, dressing percentage, meat colour, fat colour and marbling were made at the conclusion of the feeding period. RESULTS: No differences were found between cattle fed FeedMAX 15 and cattle not fed the additive in entry body weight (P = 0.99), exit body weight (P = 0.91), dressing percentage (P = 0.66), P8 fat depth (P = 0.57), meat colour (P = 0.67), marbling (P = 0.70), all diseases (P = 0.64), bovine respiratory disease (P = 0.91), or mortalities (P = 1.0). Cattle fed FeedMAX 15 reached the market specifications for body weight and fat depth in fewer mean days (P = 0.0001), had a greater average daily gain (P = 0.05), a lower feed conversion ratio (P = 0.05) and whiter fat (P < 0.0001). CONCLUSIONS: Feeding the humic and fulvic acid complex, FeedMAX 15, at 0.055 g per kg body weight per day, can increase growth rate and feed conversion efficiency in feedlot cattle. DOI: 10.1111/j.1751-0813.2007.00242.x PMID: 18271826 [Indexed for MEDLINE]
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