후디아

Evidence for the efficacy and safety of herbal weight loss preparations.

1. J Integr Med. 2019 Mar;17(2):87-92. doi: 10.1016/j.joim.2019.01.009. Epub 2019 Jan 30. Evidence for the efficacy and safety of herbal weight loss preparations. Farrington R(1), Musgrave IF(2), Byard RW(3). Author information: (1)Adelaide Medical School, The University of Adelaide, Adelaide, S

Characterization of in vitro pharmacokinetic properties of hoodigogenin A from Hoodia gordonii.

2. Planta Med. 2010 Jan;76(1):62-9. doi: 10.1055/s-0029-1185949. Epub 2009 Jul 28. Characterization of in vitro pharmacokinetic properties of hoodigogenin A from Hoodia gordonii. Madgula VL(1), Avula B, Pawar RS, Shukla YJ, Khan IA, Walker LA, Khan SI. Author information: (1)National Center for

Efficacy and acceptance of a commercial Hoodia parviflora product for support of appetite and weight control in a consumer trial.

1. J Med Food. 2015 Feb;18(2):250-8. doi: 10.1089/jmf.2013.0178. Epub 2014 Dec 2. Efficacy and acceptance of a commercial Hoodia parviflora product for support of appetite and weight control in a consumer trial. Landor M(1), Benami A, Segev N, Loberant B. Author information: (1)1 Department of Medicine, Albert Einstein College of Medicine , New York, New York, USA . Species of Hoodia Sweet ex Decne., family Apocynaceae, a southern African succulent plant, have been recognized for their appetite suppressing properties. Products that support appetite and weight control have been developed in Israel from locally cultivated Hoodia spp. To study consumer acceptance, efficacy of, and tolerance for a frozen product based on whole aerial parts of Hoodia parviflora N.E. Br., we initiated and conducted this single-blind, randomized, placebo-controlled consumer trial. Volunteer participants ingested flavored 3 g frozen Hoodia or placebo cubes for 40 days. Subjects were weighed and measured and baseline body-mass index was determined. Adverse events were monitored and eight mild, transient, possible treatment-emergent events were reported. No moderate, severe, or chronic events were reported. On days 1, 10, and 40, subjects self-reported their perceptions of food consumption, hunger development, incidence and control of food cravings, and efficacy of the product. On day 40, the treatment group demonstrated a statistically significant decrease in measured quantitative parameters against the placebo and reported a positive perception of the product. DOI: 10.1089/jmf.2013.0178 PMID: 25453380 [Indexed for MEDLINE]

Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial.

2. Am J Clin Nutr. 2011 Nov;94(5):1171-81. doi: 10.3945/ajcn.111.020321. Epub 2011 Oct 12. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Blom WA(1), Abrahamse SL, Bradford R, Duchateau GS, Theis W, Orsi A, Ward CL, Mela DJ. Author information: (1)Unilever Research & Development, Vlaardingen, Netherlands. wendy.blom@unilever.com BACKGROUND: Extracts from Hoodia gordonii have been shown to decrease food intakes and body weights in animals and were proposed as a food supplement or ingredient for weight management. OBJECTIVE: We assessed the safety and efficacy of a 15-d repeated consumption of H. gordonii purified extract (HgPE) relative to a placebo in humans. DESIGN: Healthy, overweight women, who were stratified by percentage body fat, received either HgPE (n = 25) or a placebo (n = 24) for 15 d. Subjects were resident in a clinic for a 4-d run-in period and a 15-d treatment period in which they received 2 servings/d of 1110 mg HgPE or a placebo formulated in a yogurt drink 1 h before breakfast and dinner. Subjects were otherwise allowed to eat ad libitum from standardized menus. RESULTS: There were no serious adverse events, but HgPE was less well tolerated than was the placebo because of episodes of nausea, emesis, and disturbances of skin sensation. Blood pressure, pulse, heart rate, bilirubin, and alkaline phosphatase showed significant (P < 0.05) increases in the HgPE group. Mean effects on ad libitum energy intakes and body weights did not differ significantly between the HgPE- and placebo-treatment groups (P > 0.05). CONCLUSIONS: In comparison with a matched placebo, the consumption of HgPE for 15 d appeared to be associated with significant adverse changes in some vital signs and laboratory parameters. HgPE was less well tolerated than was the placebo and did not show any significant effects on energy intakes or body weights relative to the placebo. This trial was registered at clinicaltrials.gov as NCT01306422. DOI: 10.3945/ajcn.111.020321 PMID: 21993434 [Indexed for MEDLINE]

Effects of Hoodia Parviflora on satiety, abdominal obesity and weight in a group of overweight subjects: a randomized, blinded, placebo-controlled trial.

3. Minerva Gastroenterol Dietol. 2020 Sep;66(3):211-218. doi: 10.23736/S1121-421X.20.02669-0. Epub 2020 Mar 24. Effects of Hoodia Parviflora on satiety, abdominal obesity and weight in a group of overweight subjects: a randomized, blinded, placebo-controlled trial. Perna S(1), Infantino V(2), Peroni G(3), Gasparri C(4), Faliva MA(4), Naso M(4), Alalwan TA(1), Borsani F(5), Berardi M(5), Ilyas Z(1), Alaali Z(1), Alsowaid L(1), Spadaccini D(4), Rondanelli M(2)(6). Author information: (1)Department of Biology, College of Science, University of Bahrain, Sakhir, Bahrain. (2)Unit of Human and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. (3)Unit of Endocrinology and Nutrition, Azienda di Servizi alla Persona Istituto Santa Margherita, University of Pavia, Pavia, Italy - gabriella.peroni01@universitadipavia.it. (4)Unit of Endocrinology and Nutrition, Azienda di Servizi alla Persona Istituto Santa Margherita, University of Pavia, Pavia, Italy. (5)PromoPharma S.p.A. Acquaviva, San Marino, Italy. (6)IRCCS Mondino Foundation, Pavia, Italy. BACKGROUND: This study aimed to assess the effects of supplementation with Hoodia Parviflora (H. Parviflora) at 9 mg+200 mg of fructo-oligosaccharides on weight loss, body composition, hydration and satiety parameters. METHODS: A randomized blinded controlled trial was conducted in a sample of 30 overweight and obese patients (5 males and 25 females). Patients were randomly assigned in 2 groups: the intervention group, which received H. Parviflora twice a day for 4 weeks and the control group, which received a placebo. RESULTS: After a 4-week follow-up period, the study results showed an improvement of Δ=-1.632 kg (Confidence Interval [CI]95% -2.545; -0.719) and a statistically significant decrease in waist circumference (WC) compared with the placebo group -2.080 cm ([CI]95% -4.082; -0.078). The visual analogue scale reported an improvement of satiety sensation after day 5 (P=0.001). CONCLUSIONS: This study shows for the first time the simultaneous effect of H. Parviflora on weight loss, decreasing satiety, and improving fat mass, in particular Visceral Adipose Tissue (VAT). DOI: 10.23736/S1121-421X.20.02669-0 PMID: 32218424 [Indexed for MEDLINE]

The effect of two weeks ingestion of a bitter tastant mixture on energy intake in overweight females.

4. Appetite. 2016 Dec 1;107:268-273. doi: 10.1016/j.appet.2016.08.013. Epub 2016 Aug 10. The effect of two weeks ingestion of a bitter tastant mixture on energy intake in overweight females. Peters HPF(1), Koppenol W(2), Schuring EAH(2), Gouka R(2), Mela DJ(2), Blom WAM(2). Author information: (1)Unilever Research & Development, Vlaardingen, The Netherlands. Electronic address: harry.peters@unilever.com. (2)Unilever Research & Development, Vlaardingen, The Netherlands. Triggering of gastro-intestinal bitter taste receptors might have implications for appetite and food intake, but the evidence in humans is mixed and limited to acute studies. We previously reported that 15-days consumption of drinks with purified Hoodia gordonii extract and its taste-matched control both produced similar, significant energy intake (EI) reductions in females in an in-patient setting, with no significant differences between treatments. In that study the control was matched to Hoodia flavour and bitterness using Raisin Flavour (RF), Sucrose Octa Acetate (SOA) and Quassia Extract (QE). As triggering of gastrointestinal bitter receptors might have produced shared effects on EI, our objective here was to assess the effects of sustained exposure to capsules containing the same bitter RF + SOA + QE mix itself on EI, compared to a non-bitter placebo. In this randomized, double-blind study, sixty slightly overweight women in parallel groups consumed twice-daily capsules without (placebo) or with the tastant mixture (0.88 mg SOA, 0.088 mg QE, 0.22 mg RF) on days 1-14. On day 0 all subjects received placebo capsules at 0800 and 1600, ad libitum meals at 0900, 1300, 1700, and snacks after 1900. On day 14 these test procedures were repeated. Changes in EI on days 14 versus 0 between treatment groups were assessed using ANCOVA. Total EI differences on days 14 versus 0 were not significant (mean active-placebo treatment difference -109 kcal, SE 71, P = 0.13), nor was this significant when analyzed separately for each meal within the test day. Body weight changes were negligible. In conclusion, sustained exposure to these encapsulated bitter tastants did not significantly affect EI in overweight females. Copyright © 2016 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.appet.2016.08.013 PMID: 27522037 [Indexed for MEDLINE]