음양곽 (에피메디움)

Efficacy and mechanisms of Icariin in the treatment of Alzheimer's disease: a systematic review and meta-analysis of a preclinical study.

1. Eur J Pharmacol. 2026 Mar 28;1019:178706. doi: 10.1016/j.ejphar.2026.178706. Epub 2026 Mar 4. Efficacy and mechanisms of Icariin in the treatment of Alzheimer's disease: a systematic review and meta-analysis of a preclinical study. Cui J(1), Huang R(2), Dong X(3). Author information: (1)Depa

Neuroprotective effects of icariin in animal models of depression and anxiety: a systematic review of preclinical studies.

2. BMC Complement Med Ther. 2026 Feb 24;26(1):120. doi: 10.1186/s12906-026-05302-9. Neuroprotective effects of icariin in animal models of depression and anxiety: a systematic review of preclinical studies. He JX(1), Lin CH(1), Ling JA(1), Kuo CL(2), Lee MS(3). Author information: (1)Department

The efficacy and safety of Epimedium in the treatment of primary osteoporosis: a systematic review and meta-analysis.

3. Front Med (Lausanne). 2025 Sep 19;12:1675160. doi: 10.3389/fmed.2025.1675160. eCollection 2025. The efficacy and safety of Epimedium in the treatment of primary osteoporosis: a systematic review and meta-analysis. Zhang XQ(#)(1)(2), Hua ZH(#)(1), Huang CJ(#)(1), Chen HY(1), Hu ZR(3), Zhang M

Icariside II: natural occurrence, biotransformation, pharmacological activity, synthetic modification, pharmacokinetics, and bioavailability.

4. J Pharm Pharmacol. 2025 Oct 30;77(11):1491-1512. doi: 10.1093/jpp/rgaf065. Icariside II: natural occurrence, biotransformation, pharmacological activity, synthetic modification, pharmacokinetics, and bioavailability. Ni HTN(1), Linh NN(2), Nhung PTT(2), Dao PTB(2), Manh VQ(2), Son NT(3). Auth

Method of invigorating spleen and replenishing kidney and resolving phlegm for obesity-type polycystic ovary syndrome: a network meta-analysis and summary of herbal prescription regularity.

5. Front Med (Lausanne). 2025 Jul 28;12:1609131. doi: 10.3389/fmed.2025.1609131. eCollection 2025. Method of invigorating spleen and replenishing kidney and resolving phlegm for obesity-type polycystic ovary syndrome: a network meta-analysis and summary of herbal prescription regularity. Lyu Y(

The effects of various nutritional supplements in patients with chronic obstructive pulmonary disease: a network meta-analysis.

6. BMC Pulm Med. 2025 May 8;25(1):220. doi: 10.1186/s12890-025-03667-0. The effects of various nutritional supplements in patients with chronic obstructive pulmonary disease: a network meta-analysis. Zeng J(#)(1), Cheng J(#)(1), Zhu L(2), Tang S(1). Author information: (1)The First Affiliated Ho

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: a systematic review and meta-analysis.

7. Front Pharmacol. 2024 Nov 18;15:1505926. doi: 10.3389/fphar.2024.1505926. eCollection 2024. Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: a systematic review and meta-analysis. Li J(1), Huang X(1), Yuan Y(2), Zhang H(3), Zhou H(1), Xiong W(1), Li Y(1), Zhang Z(1

Neurovascular glial unit: A target of phytotherapy for cognitive impairments.

8. Phytomedicine. 2023 Oct;119:155009. doi: 10.1016/j.phymed.2023.155009. Epub 2023 Aug 2. Neurovascular glial unit: A target of phytotherapy for cognitive impairments. Chen L(1), Zhen Y(1), Wang X(1), Wang J(2), Zhu G(3). Author information: (1)Key Laboratory of Xin'an Medicine, the Ministry of

A systematic review of traditional uses, phytochemistry, pharmacology and toxicity of Epimedium koreanum Nakai.

9. J Ethnopharmacol. 2024 Jan 10;318(Pt B):116957. doi: 10.1016/j.jep.2023.116957. Epub 2023 Aug 6. A systematic review of traditional uses, phytochemistry, pharmacology and toxicity of Epimedium koreanum Nakai. Qian HQ(1), Wu DC(1), Li CY(1), Liu XR(1), Han XK(1), Peng Y(1), Zhang H(1), Zhao B

Epimedium for Osteoporosis Based on Western and Eastern Medicine: An Updated Systematic Review and Meta-Analysis.

10. Front Pharmacol. 2022 Mar 31;13:782096. doi: 10.3389/fphar.2022.782096. eCollection 2022. Epimedium for Osteoporosis Based on Western and Eastern Medicine: An Updated Systematic Review and Meta-Analysis. Shi S(1), Wang F(1), Huang Y(1), Chen B(2), Pei C(1), Huang D(1), Wang X(1), Wang Y(1),

A Randomized, Double-Blind, Placebo-Controlled Study Investigating the Safety and Efficacy of a Herbal Formulation on Knee Joint Function in Adults with Knee Osteoarthritis.

11. J Integr Complement Med. 2025 Jan;31(1):54-63. doi: 10.1089/jicm.2023.0124. Epub 2024 Oct 14. A Randomized, Double-Blind, Placebo-Controlled Study Investigating the Safety and Efficacy of a Herbal Formulation on Knee Joint Function in Adults with Knee Osteoarthritis. Li L(1), Wang Y(1), Wan

Randomized, double-blind, placebo-controlled trial to examine the safety, pharmacokinetics and effects of Epimedium prenylflavonoids, on bone specific alkaline phosphatase and the osteoclast adaptor protein TRAF6 in post-menopausal women.

12. Phytomedicine. 2021 Oct;91:153680. doi: 10.1016/j.phymed.2021.153680. Epub 2021 Jul 25. Randomized, double-blind, placebo-controlled trial to examine the safety, pharmacokinetics and effects of Epimedium prenylflavonoids, on bone specific alkaline phosphatase and the osteoclast adaptor prote

A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum).

13. Int J Environ Res Public Health. 2021 Apr 1;18(7):3671. doi: 10.3390/ijerph18073671. A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum).

Pharmacokinetics of Prenylflavonoids following Oral Ingestion of Standardized Epimedium Extract in Humans.

14. Planta Med. 2019 Mar;85(4):347-355. doi: 10.1055/a-0806-7673. Epub 2018 Dec 6. Pharmacokinetics of Prenylflavonoids following Oral Ingestion of Standardized Epimedium Extract in Humans. Teo YL(1), Cheong WF(1), Cazenave-Gassiot A(2), Ji S(3), Logan S(4)(5), Lee ZXK(4), Li J(1), Seng KY(6), L

[Clinical study of medicinal-cake-separated moxibustion for senile osteoporosis].

15. Zhongguo Zhen Jiu. 2017 May 12;37(5):473-476. doi: 10.13703/j.0255-2930.2017.05.005. [Clinical study of medicinal-cake-separated moxibustion for senile osteoporosis]. [Article in Chinese] Zeng Y(1), Bi D(2), Yi Z(3), Lu J(1), Zhong F(1), Jiang B(1). Author information: (1)Department of Ort

Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic extract and other five of natural medicines - comparison with traditional herbal medicines (Kampo).

45. Aging Male. 2014 Jun;17(2):112-6. doi: 10.3109/13685538.2013.771328. Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic extract and other five of natural medicines - comparison with traditional herbal medicines (Kampo). Nishimatsu H(1), Kitamura T,

The effects of Chinese yam-epimedium mixture on respiratory function and quality of life in patients with chronic obstructive pulmonary disease.

7. J Tradit Chin Med. 2012 Jun;32(2):203-7. doi: 10.1016/s0254-6272(13)60012-6. The effects of Chinese yam-epimedium mixture on respiratory function and quality of life in patients with chronic obstructive pulmonary disease. Zhao YL(1), Song HR, Fei JX, Liang Y, Zhang BH, Liu QP, Wang J, Hu P. A

Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures.

24. J Bone Miner Metab. 2012 Sep;30(5):517-24. doi: 10.1007/s00774-012-0351-7. Epub 2012 Jun 22. Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures. Deng WM(1), Zhang P, Huang H, Shen YG, Yang QH, Cui WL, He YS, Wei

A randomized, double-blind, placebo-controlled crossover study of Cappra® for the treatment of mild or mild to moderate erectile dysfunction in Thai male.

37. Afr J Tradit Complement Altern Med. 2012 Dec 31;10(2):310-5. eCollection 2013. A randomized, double-blind, placebo-controlled crossover study of Cappra® for the treatment of mild or mild to moderate erectile dysfunction in Thai male. Punyawudho B(1), Puttilerpong C, Wirotsaengthong S, Aramwit

[Effect of bushen qiangdu recipe on osteoporosis and bone loss of patients with ankylosing spondylitis].

48. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Apr;31(4):471-5. [Effect of bushen qiangdu recipe on osteoporosis and bone loss of patients with ankylosing spondylitis]. [Article in Chinese] Wang H(1), Yan XP, Kong WP. Author information: (1)Department of Rhumatology, China-Japan Friendship Hospit

Pharmacodynamic Material Basis of the Components of Four Epimedium Species with Activities Against Hepatocellular Carcinoma Based on Biological Target Networks and Multi-Omics Analysis.

31. J Hepatocell Carcinoma. 2026 Apr 23;13:578719. doi: 10.2147/JHC.S578719. eCollection 2026. Pharmacodynamic Material Basis of the Components of Four Epimedium Species with Activities Against Hepatocellular Carcinoma Based on Biological Target Networks and Multi-Omics Analysis. Liao X(1)(2),

Icariin Modulates the Reproductive-Immune Axis: Molecular Insights and Therapeutic Potential.

32. Curr Issues Mol Biol. 2026 Apr 1;48(4):366. doi: 10.3390/cimb48040366. Icariin Modulates the Reproductive-Immune Axis: Molecular Insights and Therapeutic Potential. Wang R(1)(2), Chen Y(2)(3)(4), Xiao Q(1)(2), Tang L(1)(2), Zhang N(2)(5). Author information: (1)Department of Traditional Chin

Exploring the therapeutic synergy of drug-lifestyle interventions in fluorosis: a randomized trial on cardiovascular metabolic outcomes from the China fluorosis cohort (CFC).

2. Front Pharmacol. 2026 Mar 31;17:1737666. doi: 10.3389/fphar.2026.1737666. eCollection 2026. Exploring the therapeutic synergy of drug-lifestyle interventions in fluorosis: a randomized trial on cardiovascular metabolic outcomes from the China fluorosis cohort (CFC). Lu Y(#)(1), Tao F(#)(1),

Synergistic action of Yinyanghuo A and Magnograndiolide against ovarian cancer: A computational prediction of targets and mechanism via network pharmacology and molecular simulations.

34. Comput Biol Chem. 2026 Apr 1;123:109028. doi: 10.1016/j.compbiolchem.2026.109028. Online ahead of print. Synergistic action of Yinyanghuo A and Magnograndiolide against ovarian cancer: A computational prediction of targets and mechanism via network pharmacology and molecular simulations. Wa

A comprehensive narrative review of Epimedium and its bioactive compounds in respiratory diseases.

25. J Pharm Anal. 2026 Mar;16(3):101374. doi: 10.1016/j.jpha.2025.101374. Epub 2025 Jun 20. A comprehensive narrative review of Epimedium and its bioactive compounds in respiratory diseases. Song L(1), Lei C(2), Zheng C(1), Liu Y(1), Liu J(1), Yao D(1), Huang X(1). Author information: (1)Divisi

Baohuoside I Combated Cryptocaryon irritans via Dual Targeting of Parasite Apoptosis and Host Defense Enhancement.

2. Antioxidants (Basel). 2026 Mar 21;15(3):396. doi: 10.3390/antiox15030396. Baohuoside I Combated Cryptocaryon irritans via Dual Targeting of Parasite Apoptosis and Host Defense Enhancement. Lin Y(1), Huang L(2), Yuan Y(1), Lin Z(1), Huang L(1), Lin T(1), Lin A(1), Zhu Y(1), Jiang S(1), Huang Y

[Identification of efferocytosis-related genes in osteoarthritis and prediction of traditional Chinese medicines based on bioinformatics and machine learning].

16. Nan Fang Yi Ke Da Xue Xue Bao. 2026 Mar 20;46(3):693-706. doi: 10.12122/j.issn.1673-4254.2026.03.23. [Identification of efferocytosis-related genes in osteoarthritis and prediction of traditional Chinese medicines based on bioinformatics and machine learning]. [Article in Chinese; Abstract a

A potent icaritin derivative ameliorates Parkinson's disease via GPER-mediated mitophagy restoration and dopaminergic neuroprotection.

6. Bioorg Chem. 2026 Jun 15;174:109759. doi: 10.1016/j.bioorg.2026.109759. Epub 2026 Mar 15. A potent icaritin derivative ameliorates Parkinson's disease via GPER-mediated mitophagy restoration and dopaminergic neuroprotection. Wang X(1), Cao X(2), Cai M(1), Zhao R(1), Zheng Y(1), Zhang M(3), Sh

Targeting the PINK1/Parkin-FNDC5 pathway: a novel mechanism of icariin in regulating muscle-bone metabolic coupling in osteosarcopenia.

36. J Transl Med. 2026 Mar 17;24(1):389. doi: 10.1186/s12967-026-08017-0. Targeting the PINK1/Parkin-FNDC5 pathway: a novel mechanism of icariin in regulating muscle-bone metabolic coupling in osteosarcopenia. Zhao M(#)(1)(2), Yuan F(#)(1), Liu C(2), Guo T(3). Author information: (1)Guizhou Prov

Icariside II suppresses NF-κB/STAT3 signaling to prevent the progression of chronic atrophic gastritis toward gastric cancer.

24. J Clin Biochem Nutr. 2026 Mar 1;78(2):158-167. doi: 10.3164/jcbn.25-203. Epub 2026 Jan 16. Icariside II suppresses NF-κB/STAT3 signaling to prevent the progression of chronic atrophic gastritis toward gastric cancer. Li M(1), Shang H(2), Liu Q(3). Author information: (1)School of Biological