L-아르기닌

Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.

1. Clin Nutr ESPEN. 2025 Oct;69:653-664. doi: 10.1016/j.clnesp.2025.07.1130. Epub 2025 Aug 9. Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials. Luo P(1), Chen J(2)

The effects of nutritional supplementation for children and adolescents with sickle cell disease: A systematic review and meta-analyses.

2. Clin Nutr. 2025 Apr;47:157-168. doi: 10.1016/j.clnu.2025.02.016. Epub 2025 Feb 17. The effects of nutritional supplementation for children and adolescents with sickle cell disease: A systematic review and meta-analyses. Orsi BC(1), Gorski D(2), Krul NE(3), Wiens A(4), Brito M(5), Tonin FS(6),

L-Arginine and L-Citrulline for Prevention and Treatment of Pre-Eclampsia: A Systematic Review and Meta-Analysis.

3. BJOG. 2025 May;132(6):698-708. doi: 10.1111/1471-0528.18070. Epub 2025 Jan 12. L-Arginine and L-Citrulline for Prevention and Treatment of Pre-Eclampsia: A Systematic Review and Meta-Analysis. Makama M(1)(2), McDougall ARA(1)(3), Cao J(1), Mills K(1), Nguyen PY(1), Hastie R(4), Ammerdorffer A

Effects of Different Dietary Supplements on Swimming Performance: A Systematic Review and Network Meta-Analysis.

4. Nutrients. 2024 Dec 26;17(1):33. doi: 10.3390/nu17010033. Effects of Different Dietary Supplements on Swimming Performance: A Systematic Review and Network Meta-Analysis. Huang D(1)(2), Wang X(1), Takagi H(3), Mo S(4), Wang Z(5), Chow DH(2), Huang B(5). Author information: (1)School of Physi

L-arginine impact on inflammatory and cardiac markers in patients undergoing coronary artery bypass graft: a systematic review and meta-analysis of randomized controlled trials.

5. BMC Cardiovasc Disord. 2024 Nov 13;24(1):641. doi: 10.1186/s12872-024-04318-8. L-arginine impact on inflammatory and cardiac markers in patients undergoing coronary artery bypass graft: a systematic review and meta-analysis of randomized controlled trials. Mohammadi Z(1), Ravankhah M(2), Ahma

Nutraceutical interventions for erectile dysfunction: a systematic review and network meta-analysis.

6. J Sex Med. 2024 Oct 31;21(11):1054-1063. doi: 10.1093/jsxmed/qdae123. Nutraceutical interventions for erectile dysfunction: a systematic review and network meta-analysis. Barbonetti A(1), Tienforti D(1), Antolini F(1), Spagnolo L(1), Cavallo F(2), Di Pasquale AB(3), Maggi M(4)(5)(6), Corona G

Antioxidant supplementation for sickle cell disease.

7. Cochrane Database Syst Rev. 2024 May 22;5(5):CD013590. doi: 10.1002/14651858.CD013590.pub2. Antioxidant supplementation for sickle cell disease. Bolarinwa AB(1), Oduwole O(2), Okebe J(3), Ogbenna AA(4), Otokiti OE(1), Olatinwo AT(1). Author information: (1)Department of Haematology & Blood T

Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use.

8. Nutrients. 2023 Aug 22;15(17):3677. doi: 10.3390/nu15173677. Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use. Petre GC(1), Francini-Pesenti F(2), Vitagliano A(3), Grande G(1), Ferlin A(1), Garolla A(1). Author inf

Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis.

9. Nutrients. 2023 Apr 21;15(8):1995. doi: 10.3390/nu15081995. Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis. Porto AA(1)(2), Gonzaga LA(1)(2), Benjamim CJR(3), Valenti VE

l-arginine supplementation improved neonatal outcomes in pregnancies with hypertensive disorder or intrauterine growth restriction: A systematic review and meta-analysis of randomized controlled trials.

10. Clin Nutr. 2022 Jul;41(7):1512-1522. doi: 10.1016/j.clnu.2022.05.014. Epub 2022 May 23. l-arginine supplementation improved neonatal outcomes in pregnancies with hypertensive disorder or intrauterine growth restriction: A systematic review and meta-analysis of randomized controlled trials.

Revealing the temporal metabolic trajectory and potential pharmacodynamic substances of Da-Cheng-Qi Decoction in treating patients with acute pancreatitis: A serum metabolomics-based study.

11. J Ethnopharmacol. 2026 Jun 12;364:121522. doi: 10.1016/j.jep.2026.121522. Epub 2026 Mar 11. Revealing the temporal metabolic trajectory and potential pharmacodynamic substances of Da-Cheng-Qi Decoction in treating patients with acute pancreatitis: A serum metabolomics-based study. Wang Y(1)

Assessment of the effectiveness and safety of two-month oral supplementation with L-arginine depending on the type of lipid metabolism disorder in patients with atherosclerotic lower limb ischemia.

12. J Physiol Pharmacol. 2025 Oct;76(5):535-546. doi: 10.26402/jpp.2025.5.05. Epub 2025 Nov 28. Assessment of the effectiveness and safety of two-month oral supplementation with L-arginine depending on the type of lipid metabolism disorder in patients with atherosclerotic lower limb ischemia. M

Lessening the erosive influence of electrolyte sports drinks on teeth using L-arginine and aqueous Miswak extract.

13. Head Face Med. 2025 Nov 29;21(1):84. doi: 10.1186/s13005-025-00560-3. Lessening the erosive influence of electrolyte sports drinks on teeth using L-arginine and aqueous Miswak extract. Elgamily H(1)(2), Safwat E(3), Sayed R(3), Mosbah S(4), Yossef A(5). Author information: (1)Restorative and

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.

14. Int J Sport Nutr Exerc Metab. 2025 Nov 17;36(1):1-12. doi: 10.1123/ijsnem.2025-0125. Print 2026 Jan 1. Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study. Borges CC(1), Alves da Silva W(2), de Sá Filho AS(2),

Dose-Response Effect of Watermelon Consumption on Ambulatory Blood Pressure in Adults with Elevated Blood Pressure: A Randomized Controlled Pilot Trial.

15. Nutrients. 2025 Sep 26;17(19):3073. doi: 10.3390/nu17193073. Dose-Response Effect of Watermelon Consumption on Ambulatory Blood Pressure in Adults with Elevated Blood Pressure: A Randomized Controlled Pilot Trial. Singh K(1), Liao H(2), Edirisinghe I(1), Burton-Freeman B(1), Sandhu AK(1)(3).

Efficacy Of Combined Nutritional And Pharmacological Interventions In PCOS: A Six Month Randomized Controlled Trial.

26. Naunyn Schmiedebergs Arch Pharmacol. 2026 Feb;399(3):3461-3476. doi: 10.1007/s00210-025-04626-6. Epub 2025 Sep 30. Efficacy Of Combined Nutritional And Pharmacological Interventions In PCOS: A Six Month Randomized Controlled Trial. Zahra M(1), Shah M(2), Iqbal F(1), Zubair T(3), Habib R(4),

Acute effects of combined supplementation of L-arginine and citrulline malate on aerobic, anaerobic, and CrossFit exercise performance.

32. Sci Rep. 2025 Sep 26;15(1):33067. doi: 10.1038/s41598-025-16374-x. Acute effects of combined supplementation of L-arginine and citrulline malate on aerobic, anaerobic, and CrossFit exercise performance. Selvaraj S(1), Petridis L(2), Majtényi H(3), Bartha H(3), Tóth Á(3), Utczás K(3), Szilágy

Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial.

11. J Cardiol. 2025 Dec;86(6):561-567. doi: 10.1016/j.jjcc.2025.08.017. Epub 2025 Sep 4. Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial. Ogaw

Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder: A Randomized Clinical Trial.

17. JAMA. 2025 Oct 21;334(15):1358-1372. doi: 10.1001/jama.2025.13481. Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder: A Randomized Clinical Trial. Robison R(1), Barrow R(2), Conant C(2), Foster E(3), Freedman JM(2), Jacobsen PL(2), Jemison J(2), Karas SM(2), Karlin DR(2

The efficacy of oral L-arginine therapy for the treatment of vaso-occlusive pain episodes in children with sickle cell disease.

4. Pediatr Hematol Oncol. 2025 Sep-Oct;42(6-7):354-366. doi: 10.1080/08880018.2025.2549365. Epub 2025 Aug 27. The efficacy of oral L-arginine therapy for the treatment of vaso-occlusive pain episodes in children with sickle cell disease. Abd Elglil AM(1), El-Shanshory MR(1), Elsharkawy HM(1), Ke

Metabolic potentiation of antibiotic killing by L-arginine in drug-resistant Edwardsiella tarda.

16. mSystems. 2026 Feb 17;11(2):e0150925. doi: 10.1128/msystems.01509-25. Epub 2025 Dec 23. Metabolic potentiation of antibiotic killing by L-arginine in drug-resistant Edwardsiella tarda. Yan B-b(1)(2), Li N(3), Zhou Y(4), Kang L-l(1)(2), Dong X-s(3), Xu X(3), An L(3), Meng Q-l(3), Wang X-r(3)

Allosteric modulation of M1 or M4 muscarinic receptors restores eNOS expression and L-arginine metabolism in dementia models and synergizes with NO releasers.

1. Pharmacol Biochem Behav. 2025 Nov;256:174085. doi: 10.1016/j.pbb.2025.174085. Epub 2025 Aug 23. Allosteric modulation of M1 or M4 muscarinic receptors restores eNOS expression and L-arginine metabolism in dementia models and synergizes with NO releasers. Płoska A(1), Radulska A(2), Siekierzyc

L-arginine synergistic with 5-fluorouracil intervenes in DNA damage repair via the DNA-PKcs/ATM/ATR pathway in hepatocellular carcinoma cells.

29. Acta Biochim Biophys Sin (Shanghai). 2025 Aug 22;58(3):621-637. doi: 10.3724/abbs.2025137. L-arginine synergistic with 5-fluorouracil intervenes in DNA damage repair via the DNA-PKcs/ATM/ATR pathway in hepatocellular carcinoma cells. Wang H(1), Xie H(1), Lin Y(1), Zhang Z(1), Zhang M(1), Zha

Synergistic protective activity of sodium hydrosulfide and L-arginine against cisplatin-induced nephrotoxicity, even during nitric oxide synthase inhibition.

19. J Pharmacol Exp Ther. 2025 Jul;392(7):103618. doi: 10.1016/j.jpet.2025.103618. Epub 2025 May 27. Synergistic protective activity of sodium hydrosulfide and L-arginine against cisplatin-induced nephrotoxicity, even during nitric oxide synthase inhibition. Khurshid F(1), Iqbal J(2), Ahmad FU(3

Injectable nanosuspension based on orthoester for synergistic chemo-photothermal/gas therapy in localized cancer treatment.

12. Colloids Surf B Biointerfaces. 2025 Oct;254:114841. doi: 10.1016/j.colsurfb.2025.114841. Epub 2025 May 31. Injectable nanosuspension based on orthoester for synergistic chemo-photothermal/gas therapy in localized cancer treatment. Yang Y(1), Zhang Z(1), Shi Z(1), Liang Z(1), Yang Q(1), Yang

The Antioxidant Power of Bergamot Polyphenolic Fraction Gold Potentiates the Effects of L-Citrulline in Athlete Performance and Vasodilation in a Pilot Study.

32. Nutrients. 2025 Mar 21;17(7):1106. doi: 10.3390/nu17071106. The Antioxidant Power of Bergamot Polyphenolic Fraction Gold Potentiates the Effects of L-Citrulline in Athlete Performance and Vasodilation in a Pilot Study. Mollace R(1)(2), Macrì R(1), Serra M(1), Ritorto G(1), Ussia S(1), Scaran

Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase.

45. Behav Pharmacol. 2025 Aug 1;36(5):258-264. doi: 10.1097/FBP.0000000000000824. Epub 2025 Apr 2. Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase. Torres-López JE(1), Martínez-Martínez M, Parra-Flores LI. Author information: (1)Divisi

Synergistic effect of nanosilver fluoride with L-arginine on remineralization of early carious lesions.

41. Sci Rep. 2025 Feb 18;15(1):5993. doi: 10.1038/s41598-025-89881-6. Synergistic effect of nanosilver fluoride with L-arginine on remineralization of early carious lesions. Albahoth AS(#)(1), Jeon MJ(#)(2), Park JW(3). Author information: (1)Department of Conservative Dental Sciences, College o

Synergistic effect of cyclodextrins and electrolytes at high concentrations on protein aggregation inhibition.

26. J Pharm Sci. 2024 Dec;113(12):3543-3553. doi: 10.1016/j.xphs.2024.10.004. Epub 2024 Oct 5. Synergistic effect of cyclodextrins and electrolytes at high concentrations on protein aggregation inhibition. Fukuda M(1), Takahashi K(2), Takarada T(3), Saito S(4), Tanaka M(3). Author information:

In silico and experimental potentials of 6-shogaol and meglumine antimoniate on Leishmania major: multiple synergistic combinations through modulation of biological properties.

41. Immunol Res. 2024 Dec;72(6):1313-1326. doi: 10.1007/s12026-024-09530-4. Epub 2024 Aug 18. In silico and experimental potentials of 6-shogaol and meglumine antimoniate on Leishmania major: multiple synergistic combinations through modulation of biological properties. Shahsavari S(1), Sharifi