L-오르니틴

Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials.

1. J Cell Biochem. 2018 Nov;119(10):8336-8345. doi: 10.1002/jcb.26886. Epub 2018 Jun 22. Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials. Cai XJ(1), Wang L(1), Hu CM(2). Auth

L-ornithine supplementation in periodontitis treatment yields greater benefits than L-arginine after one year: Part II of a randomized controlled pilot study.

2. Complement Ther Med. 2025 Sep;92:103202. doi: 10.1016/j.ctim.2025.103202. Epub 2025 Jul 2. L-ornithine supplementation in periodontitis treatment yields greater benefits than L-arginine after one year: Part II of a randomized controlled pilot study. Shynkevych VI(1), Kolomiiets SV(2), Udaltso

An Open-Label Randomized Controlled Non-Inferiority Trial of Arginine Glutamate Injection for the Treatment of Mild Hepatic Encephalopathy.

3. J Dig Dis. 2025 May;26(5-6):241-249. doi: 10.1111/1751-2980.13355. Epub 2025 Jun 22. An Open-Label Randomized Controlled Non-Inferiority Trial of Arginine Glutamate Injection for the Treatment of Mild Hepatic Encephalopathy. Zhang HB(1), Zou HB(2), Gao YY(3), Wang L(4), Gao Y(2), Kong M(2), K

Intravenous versus oral 'L-ornithine-L-aspartate' in overt hepatic encephalopathy: a randomized comparative study.

4. Sci Rep. 2024 May 24;14(1):11862. doi: 10.1038/s41598-024-62293-8. Intravenous versus oral 'L-ornithine-L-aspartate' in overt hepatic encephalopathy: a randomized comparative study. Jhajharia A(1)(2), Singh S(3), Jana S(3), Ashdhir P(3), Nijhawan S(3). Author information: (1)Department of Gas

Pharmacokinetics/pharmacodynamics of L-ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes.

5. Clin Transl Sci. 2022 Jun;15(6):1449-1459. doi: 10.1111/cts.13257. Epub 2022 Mar 3. Pharmacokinetics/pharmacodynamics of L-ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes. Safadi R(1), Rahimi RS(2), Thabut

L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial.

6. Hepatology. 2022 May;75(5):1194-1203. doi: 10.1002/hep.32255. Epub 2021 Dec 21. L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial. Jain A(1), Sharma BC(1), Mahajan B(2), Srivastava S(1), Kumar A(1), Sachdeva S(1), Sonika U(

[Effect of acupuncture combined with rehabilitation training on cognitive function and amino acid metabolism in children with cerebral palsy].

7. Zhongguo Zhen Jiu. 2021 Oct 12;41(10):1095-102. doi: 10.13703/j.0255-2930.20210129-k0008. [Effect of acupuncture combined with rehabilitation training on cognitive function and amino acid metabolism in children with cerebral palsy]. [Article in Chinese; Abstract available in Chinese from the

Enhancement Effect of Poly-L-ornithine on the Nasal Absorption of Water-Soluble Macromolecules in Rats.

8. Biol Pharm Bull. 2019;42(1):144-148. doi: 10.1248/bpb.b18-00673. Enhancement Effect of Poly-L-ornithine on the Nasal Absorption of Water-Soluble Macromolecules in Rats. Omori S(1), Kamiya Y(1)(2), Yamaki T(1), Uchida M(1), Ohtake K(1), Kimura M(1), Natsume H(1). Author information: (1)Facult

Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy.

9. Int J Mol Sci. 2017 May 9;18(5):1007. doi: 10.3390/ijms18051007. Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy. Kosgodage US(1), Trindade RP(2), Thompson PR(3), Inal JM(4), Lange S(5)(6). Author informat

Enhancement effect of poly(amino acid)s on insulin uptake in alveolar epithelial cells.

10. Drug Metab Pharmacokinet. 2012;27(6):570-8. doi: 10.2133/dmpk.dmpk-12-rg-002. Epub 2012 Apr 17. Enhancement effect of poly(amino acid)s on insulin uptake in alveolar epithelial cells. Oda K(1), Yumoto R, Nagai J, Katayama H, Takano M. Author information: (1)Department of Pharmaceutics and T

The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.

11. J Med Chem. 2011 Oct 13;54(19):6919-35. doi: 10.1021/jm2008985. Epub 2011 Sep 16. The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second gene

L-ornithine and phenylacetate synergistically produce sustained reduction in ammonia and brain water in cirrhotic rats.

12. Hepatology. 2009 Jul;50(1):155-64. doi: 10.1002/hep.22897. L-ornithine and phenylacetate synergistically produce sustained reduction in ammonia and brain water in cirrhotic rats. Davies NA(1), Wright G, Ytrebø LM, Stadlbauer V, Fuskevåg OM, Zwingmann C, Davies DC, Habtesion A, Hodges SJ, Jal

Neuronal nitric oxide synthase activation is involved in insulin-mediated cardiovascular effects in the nucleus tractus solitarii of rats.

13. Neuroscience. 2009 Mar 17;159(2):727-34. doi: 10.1016/j.neuroscience.2008.12.048. Epub 2009 Jan 3. Neuronal nitric oxide synthase activation is involved in insulin-mediated cardiovascular effects in the nucleus tractus solitarii of rats. Chiang HT(1), Cheng WH, Lu PJ, Huang HN, Lo WC, Tseng

Tubuloglomerular feedback-dependent modulation of renal myogenic autoregulation by nitric oxide.

14. Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R982-91. doi: 10.1152/ajpregu.00346.2005. Epub 2005 Nov 17. Tubuloglomerular feedback-dependent modulation of renal myogenic autoregulation by nitric oxide. Shi Y(1), Wang X, Chon KH, Cupples WA. Author information: (1)Biology Departme

Screening of bitterness-suppressing agents for quinine: the use of molecularly imprinted polymers.

15. J Pharm Sci. 2005 Feb;94(2):353-62. doi: 10.1002/jps.20248. Screening of bitterness-suppressing agents for quinine: the use of molecularly imprinted polymers. Ogawa T(1), Hoshina K, Haginaka J, Honda C, Tanimoto T, Uchida T. Author information: (1)School of Pharmaceutical Sciences, Mukogawa

Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: interactions with the neutral and cationic amino acid transporter on the corneal epithelium.

31. Curr Eye Res. 2004 Aug-Sep;29(2-3):153-66. doi: 10.1080/02713680490504614. Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: interactions with the neutral and cationic amino acid transporter on the corneal epithelium. Anand BS(1), Katragadda S, Na

Role of the nitric-oxide synthase isoforms during morphine-induced hyperthermia in rats.

32. J Pharmacol Exp Ther. 2003 Oct;307(1):219-22. doi: 10.1124/jpet.103.053181. Epub 2003 Sep 3. Role of the nitric-oxide synthase isoforms during morphine-induced hyperthermia in rats. Benamar K(1), Yondorf MZ, Kon D, Geller EB, Adler MW. Author information: (1)Center for Substance Abuse Resea

Population Pharmacokinetic Analysis to Assist Dose Selection of the L-Ornithine Salt of Phenylacetic Acid.

19. Clin Pharmacokinet. 2022 Apr;61(4):515-526. doi: 10.1007/s40262-021-01075-1. Epub 2021 Nov 17. Population Pharmacokinetic Analysis to Assist Dose Selection of the L-Ornithine Salt of Phenylacetic Acid. Wang X(1), Vilchez RA(2). Author information: (1)Clinical Pharmacology and Pharmacometric

A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.

13. Chronobiol Int. 2018 Sep;35(10):1445-1455. doi: 10.1080/07420528.2018.1490315. Epub 2018 Jul 3. A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock. Fukuda T(1), Haraguchi A(2), Takahashi M(2), Nakaoka T(3), Fu

Can ammonia scavenging treat MASLD? Evaluating the evidence for L-ornithine L-aspartate-A systematic review.

47. Eur J Clin Invest. 2026 Feb;56(2):e70185. doi: 10.1111/eci.70185. Can ammonia scavenging treat MASLD? Evaluating the evidence for L-ornithine L-aspartate-A systematic review. Ismaiel A(1), Ciornolutchii V(1), Popa SL(1), Dumitrascu DL(1). Author information: (1)2nd Department of Internal Med

Aminoglycosides, vancomycin, and metronidazole for people with cirrhosis and hepatic encephalopathy.

9. Cochrane Database Syst Rev. 2026 Feb 3;2(2):CD012734. doi: 10.1002/14651858.CD012734.pub2. Aminoglycosides, vancomycin, and metronidazole for people with cirrhosis and hepatic encephalopathy. Jeyaraj R(1), Zacharias HD(1), Vadera S(1), Low ZY(1), Gluud LL(2), Morgan MY(1). Author informatio

Safety assessment of L-ornithine oral intake in healthy subjects: a systematic review.

11. Amino Acids. 2025 May 5;57(1):23. doi: 10.1007/s00726-025-03455-4. Safety assessment of L-ornithine oral intake in healthy subjects: a systematic review. Yang H(1), Kuramochi Y(1), Sato S(1), Sakai R(1), Hayamizu K(2). Author information: (1)Laboratory of Food Chemistry, Yokohama University

Efficacy of L-ornithine L-aspartate for minimal hepatic encephalopathy in patients with cirrhosis: A meta-analysis of randomized controlled trials.

22. Arab J Gastroenterol. 2024 May;25(2):84-92. doi: 10.1016/j.ajg.2024.01.006. Epub 2024 Feb 24. Efficacy of L-ornithine L-aspartate for minimal hepatic encephalopathy in patients with cirrhosis: A meta-analysis of randomized controlled trials. He Q(1), Mao C(1), Chen Z(1), Zeng Y(1), Deng Y(1)

Primary prevention of hepatic encephalopathy post-TIPS: A systematic review and meta-analysis.

28. Medicine (Baltimore). 2023 Sep 22;102(38):e35266. doi: 10.1097/MD.0000000000035266. Primary prevention of hepatic encephalopathy post-TIPS: A systematic review and meta-analysis. Liang A(1), Brar S(1), Almaghrabi M(2)(3), Khan MQ(4)(5), Qumosani K(4)(5), Teriaky A(4)(5). Author information

Neutrophil Extracellular Traps (NETs) and Vasculitis.

38. Int J Med Sci. 2021 Feb 3;18(7):1532-1540. doi: 10.7150/ijms.53728. eCollection 2021. Neutrophil Extracellular Traps (NETs) and Vasculitis. Arneth B(1), Arneth R(2). Author information: (1)Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University Hospital of

Comparative Efficacy of Treatment Options for Minimal Hepatic Encephalopathy: A Systematic Review and Network Meta-Analysis.

49. Clin Gastroenterol Hepatol. 2020 Apr;18(4):800-812.e25. doi: 10.1016/j.cgh.2019.08.047. Epub 2019 Aug 30. Comparative Efficacy of Treatment Options for Minimal Hepatic Encephalopathy: A Systematic Review and Network Meta-Analysis. Dhiman RK(1), Thumburu KK(2), Verma N(3), Chopra M(3), Rathi

Beneficial effects of L-ornithine L-aspartate for prevention of overt hepatic encephalopathy in patients with cirrhosis: a systematic review with meta-analysis.

2. Metab Brain Dis. 2020 Jan;35(1):75-81. doi: 10.1007/s11011-019-00463-8. Epub 2019 Jul 23. Beneficial effects of L-ornithine L-aspartate for prevention of overt hepatic encephalopathy in patients with cirrhosis: a systematic review with meta-analysis. Butterworth RF(1). Author information: (

Lactulose Management of Minimal Hepatic Encephalopathy: A Systematic Review.

25. Gastroenterol Nurs. 2019 Jan/Feb;42(1):84-94. doi: 10.1097/SGA.0000000000000429. Lactulose Management of Minimal Hepatic Encephalopathy: A Systematic Review. Zucker DM(1), Redulla R. Author information: (1)Donna M. Zucker, PhD, RN, FAAN, Professor, University of Massachusetts Amherst College

L-ornithine L-aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis.

40. Cochrane Database Syst Rev. 2018 May 15;5(5):CD012410. doi: 10.1002/14651858.CD012410.pub2. L-ornithine L-aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis. Goh ET(1), Stokes CS, Sidhu SS, Vilstrup H, Gluud LL, Morgan MY. Author information: (1)UCL In