L-트립토판

The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression.

1. Nutr Rev. 2022 Jan 10;80(2):306-316. doi: 10.1093/nutrit/nuab027. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Sutanto CN(1), Loh WW(1), Kim JE(1). Author information: (1)Department of Food Science and Technology, Faculty

Bifidobacterium longum subsp. infantis B8762 modulates the infant gut-lung axis via microbial and metabolic reprogramming.

2. Microb Pathog. 2026 Jun;215:108431. doi: 10.1016/j.micpath.2026.108431. Epub 2026 Mar 7. Bifidobacterium longum subsp. infantis B8762 modulates the infant gut-lung axis via microbial and metabolic reprogramming. Ma R(1), Jia B(1), Zhang X(1), Zhao Z(1), Zhao F(1), Liong MT(2), Ali A(3), Abd

Effect of melatonin enriched with L-Tryptophan and 5-Hydroxytryptophan on sleep parameters in children with neurodevelopmental disorders.

3. Sleep Med. 2026 May;141:108818. doi: 10.1016/j.sleep.2026.108818. Epub 2026 Jan 30. Effect of melatonin enriched with L-Tryptophan and 5-Hydroxytryptophan on sleep parameters in children with neurodevelopmental disorders. Cruz-Sanabria F(1), Cenerini G(2), Bruno S(3), Ferri R(4), Fiori S(5),

Effects of combined intraduodenal administration of lauric acid and L-tryptophan on postprandial plasma glucose, glucoregulatory hormones and gastric emptying in type 2 diabetes: a double-blind, randomised, crossover study.

4. Diabetologia. 2026 Apr;69(4):900-910. doi: 10.1007/s00125-025-06630-0. Epub 2025 Dec 19. Effects of combined intraduodenal administration of lauric acid and L-tryptophan on postprandial plasma glucose, glucoregulatory hormones and gastric emptying in type 2 diabetes: a double-blind, randomise

Acute decrease in the plasma tryptophan-to-large-neutral-amino-acids ratio attenuates the effects of L-tryptophan on gut hormones and energy intake in healthy males: a randomized, cross-over, exploratory trial.

5. Am J Clin Nutr. 2025 Apr;121(4):816-825. doi: 10.1016/j.ajcnut.2025.02.016. Epub 2025 Feb 18. Acute decrease in the plasma tryptophan-to-large-neutral-amino-acids ratio attenuates the effects of L-tryptophan on gut hormones and energy intake in healthy males: a randomized, cross-over, explora

Dose-related Effects of Calcium to Enhance the Effects of L-tryptophan on Gut Hormones and Energy Intake in Obesity.

6. J Clin Endocrinol Metab. 2025 Aug 7;110(9):e2929-e2938. doi: 10.1210/clinem/dgaf008. Dose-related Effects of Calcium to Enhance the Effects of L-tryptophan on Gut Hormones and Energy Intake in Obesity. Anjom-Shoae J(1)(2), Fitzgerald PCE(1)(2), Horowitz M(1)(2)(3), Holst JJ(4)(5), Rehfeld JF

Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Constipation-Predominant Irritable Bowel Syndrome: A Single-Center, Single-Blind, Randomized Controlled Trial.

7. Am J Gastroenterol. 2024 Dec 17;120(9):2139-2153. doi: 10.14309/ajg.0000000000003257. Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Constipation-Predominant Irritable Bowel Syndrome: A Single-Center, Single-Blind, Randomized Controlled Trial. Liu J(

Intraduodenal calcium enhances the effects of L-tryptophan to stimulate gut hormone secretion and suppress energy intake in healthy males: a randomized, crossover, clinical trial.

8. Am J Clin Nutr. 2024 Sep;120(3):528-539. doi: 10.1016/j.ajcnut.2024.07.006. Epub 2024 Jul 10. Intraduodenal calcium enhances the effects of L-tryptophan to stimulate gut hormone secretion and suppress energy intake in healthy males: a randomized, crossover, clinical trial. Anjom-Shoae J(1),

Oral tryptophan activates duodenal aryl hydrocarbon receptor in healthy subjects: a crossover randomized controlled trial.

9. Am J Physiol Gastrointest Liver Physiol. 2024 Jun 1;326(6):G687-G696. doi: 10.1152/ajpgi.00306.2023. Epub 2024 Apr 9. Oral tryptophan activates duodenal aryl hydrocarbon receptor in healthy subjects: a crossover randomized controlled trial. Rueda GH(1), Causada-Calo N(1), Borojevic R(1), Nard

The Usefulness of the Low-FODMAP Diet with Limited Tryptophan Intake in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome.

10. Nutrients. 2023 Apr 11;15(8):1837. doi: 10.3390/nu15081837. The Usefulness of the Low-FODMAP Diet with Limited Tryptophan Intake in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome. Chojnacki C(1), Poplawski T(2), Blonska A(1), Konrad P(1), Chojnacki J(1), Blasiak J(3). Author

Decreased Gut Microbiome Tryptophan Metabolism and Serotonergic Signaling in Patients With Persistent Mental Health and Gastrointestinal Symptoms After COVID-19.

11. Clin Transl Gastroenterol. 2022 Oct 1;13(10):e00524. doi: 10.14309/ctg.0000000000000524. Decreased Gut Microbiome Tryptophan Metabolism and Serotonergic Signaling in Patients With Persistent Mental Health and Gastrointestinal Symptoms After COVID-19. Blackett JW(1), Sun Y(2)(3), Purpura L(4

IDO1 inhibitors are synergistic with CXCL10 agonists in inhibiting colon cancer growth.

12. Biomed Pharmacother. 2024 Oct;179:117412. doi: 10.1016/j.biopha.2024.117412. Epub 2024 Sep 9. IDO1 inhibitors are synergistic with CXCL10 agonists in inhibiting colon cancer growth. Yang M(1), Cao M(1), Zhang X(2), Fu B(1), Chen Y(1), Tan Y(1), Xuan C(1), Su Y(1), Tan D(1), Hu R(3). Author

Supplementation of l-arginine boosts the therapeutic efficacy of anticancer chemoimmunotherapy.

13. Cancer Sci. 2020 Jul;111(7):2248-2258. doi: 10.1111/cas.14490. Epub 2020 Jun 12. Supplementation of l-arginine boosts the therapeutic efficacy of anticancer chemoimmunotherapy. Satoh Y(1), Kotani H(1), Iida Y(1), Taniura T(2), Notsu Y(3), Harada M(1). Author information: (1)Department of Imm

Synergistic antitumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model.

14. J Neurosurg. 2016 Jun;124(6):1594-601. doi: 10.3171/2015.5.JNS141901. Epub 2015 Dec 4. Synergistic antitumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model. Hanihara M(1), Kawataki T(1), Oh-Oka K(2), Mitsuka K(1), Nakao A(2), Kinouchi H(1). Aut

Understanding amyloid fibril nucleation and aβ oligomer/drug interactions from computer simulations.

15. Acc Chem Res. 2014 Feb 18;47(2):603-11. doi: 10.1021/ar4002075. Epub 2013 Dec 24. Understanding amyloid fibril nucleation and aβ oligomer/drug interactions from computer simulations. Nguyen P(1), Derreumaux P. Author information: (1)Laboratoire de Biochimie Théorique, UPR 9080 CNRS, Univers

Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or paracetamol in mice.

10. Chem Biol Interact. 2013 Sep 25;205(2):148-56. doi: 10.1016/j.cbi.2013.07.005. Epub 2013 Jul 16. Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or paracetamol in mice. Rocha NF(1), Rios ER, Carvalho AM, Freire LV, Dias ML, de França Fonteles MM, de Sousa FC. Author

Inhibitory effects of N-valproyl-L-tryptophan on high potassium, low calcium and low magnesium-induced CA1 hippocampal epileptiform bursting activity in rat brain slices.

33. J Neural Transm (Vienna). 2012 Nov;119(11):1249-59. doi: 10.1007/s00702-012-0814-y. Epub 2012 May 10. Inhibitory effects of N-valproyl-L-tryptophan on high potassium, low calcium and low magnesium-induced CA1 hippocampal epileptiform bursting activity in rat brain slices. Sardo P(1), Rizzo

DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor.

26. Am J Pathol. 2012 Apr;180(4):1454-64. doi: 10.1016/j.ajpath.2012.01.003. Epub 2012 Feb 11. DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor. Al-Lamki RS(1), Lu W, Finlay S, Twohig JP, Wang EC, Tolkovsky AM, Bradley JR. Author information: (1)Departme

5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination.

37. Eur J Pharm Sci. 2010 Jan 31;39(1-3):68-75. doi: 10.1016/j.ejps.2009.10.013. Epub 2009 Nov 10. 5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination. Larsen M(1), Holm R, Jensen KG, Sveigaard C, Brodin B, Niels

Flow injection-capillary electrophoresis frontal analysis method for the study of the interactions of a series of drugs with human serum albumin.

28. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3144-50. doi: 10.1016/j.jchromb.2009.08.002. Epub 2009 Aug 7. Flow injection-capillary electrophoresis frontal analysis method for the study of the interactions of a series of drugs with human serum albumin. Liu X(1), Li S, Zh

Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan.

6. Br J Pharmacol. 2009 Aug;157(8):1380-9. doi: 10.1111/j.1476-5381.2009.00253.x. Epub 2009 Jul 7. Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan. Larsen M(1), Holm R, Jensen KG, Brodin B, Nielsen CU. Author informatio

Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.

24. J Nutr Sci Vitaminol (Tokyo). 2014;60(4):255-60. doi: 10.3177/jnsv.60.255. Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites. Hiratsuka C(1), Sano M, Fukuwatari T, Shibata K. Author information: (1)Department of Nutrition, School of Human