뮤쿠나 프루리엔스
Mucuna Pruriens (L-DOPA)
📚 관련 논문 (15편)
1. J Parkinsons Dis. 2026 Feb;16(1):99-109. doi: 10.1177/1877718X251383721. Epub 2025 Nov 21. Mucuna pruriens in untreated Parkinson's disease in sub-Saharan Africa: A 12-month, multicenter, randomized, controlled trial. Cilia R(1), Cham M(2), Obese V(3), Akpalu A(4)(5), Cereda E(6), Ame-Bruce E
2. J Neural Transm (Vienna). 2025 Nov;132(11):1673-1683. doi: 10.1007/s00702-025-02914-2. Epub 2025 Mar 26. Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia. Boonmongko
3. Clin Neuropharmacol. 2015 Sep-Oct;38(5):201-3. doi: 10.1097/WNF.0000000000000098. Mucuna pruriens in Parkinson Disease: A Kinetic-Dynamic Comparison With Levodopa Standard Formulations. Contin M(1), Lopane G, Passini A, Poli F, Iannello C, Guarino M. Author information: (1)*IRCCS-ISNB Instit
4. Parkinsonism Relat Disord. 2010 Aug;16(7):458-65. doi: 10.1016/j.parkreldis.2010.04.015. Epub 2010 May 31. A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias. Lieu CA(1), Kunselman AR, Manyam BV, Venkiteswaran K, Subramanian T.
5. CNS Neurosci Ther. 2025 Aug;31(8):e70540. doi: 10.1111/cns.70540. Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future Perspectives. Aktaş E(1), Hanağası HA(2), Özgentürk NÖ(1). Author information: (1)Faculty of Art and Science, Molecular Bio
1. Trop Anim Health Prod. 2019 Jun;51(5):1195-1202. doi: 10.1007/s11250-019-01808-2. Epub 2019 Jan 19. Effect of dietary inclusion of small quantities of Mucuna pruriens seed meal on sexual behavior, semen characteristics, and biochemical parameters in rabbit bucks (Oryctolagus cuniculus). Mutwedu VB(1)(2), Ayagirwe RBB(3), Bacigale SB(4), Mwema LM(3), Butseme S(3), Kashosi T(5), Mitima B(5), Manyawu GJ(6), Nyongesa AW(7). Author information: (1)Department of Animal Production, Faculty of Agriculture and Environmental Studies, Université Evangélique en Afrique (UEA), Bukavu, Democratic Republic of the Congo. mutweduvalence@gmail.com. (2)International Livestock Research Institute (ILRI), Bukavu, Democratic Republic of the Congo. mutweduvalence@gmail.com. (3)Department of Animal Production, Faculty of Agriculture and Environmental Studies, Université Evangélique en Afrique (UEA), Bukavu, Democratic Republic of the Congo. (4)International Institute of Tropical Agriculture (IITA), Bukavu, Democratic Republic of the Congo. (5)Bio-Medical Laboratory, Université Evangélique en Afrique (UEA), Bukavu, Democratic Republic of the Congo. (6)International Livestock Research Institute (ILRI), Bujumbura, Burundi. (7)Department of Veterinary Anatomy and Physiology, University of Nairobi, Nairobi, Kenya. The aim of this work was to investigate the effects of Mucuna pruriens seed meal (MSM) on sexual behavior, semen, and biochemical parameters in rabbit bucks. Twenty-four 12-week-old rabbit bucks weighing 1002 to 1156 g were randomly allocated to three experimental diets containing 0, 1.5, and 3% of MSM in a 3-month trial. Sexual behavior parameters such as mounting latency, mounting frequency, successful mounting frequency, intromission latency, and post ejaculatory interval were monitored at the end of the experiment by mating with receptive females. Thereafter, rabbits were weighed, stunned, and humanely sacrificed and testes, epididymis, and vas deferens were harvested for evaluation of organ weights and semen characteristics. Results indicate that supplementing rabbit diet with MSM induced a significant decrease (P < 0.05) in mounting latency (69.7%) and intromission latency (19.7%), while it significantly (P < 0.05) increased successful mounting frequency (60%) as well as relative weight of testis (33.3%) and vas deferens (54.5%). There was a dose-dependent increase (P < 0.05) in sperm motility (35.7%) and concentration (65.9%), serum albumin (19.1%) and protein concentration (9.9%), and a decrease in sperm morphological alterations (68.3%), serum cholesterol (13.4%), and urea (11.6%) in treatment groups where MSM was supplemented at 3% compared to controls. From the findings, it appears MSM is a potential enhancer of male reproductive performance that can be recommended to rabbit farmers for improving reproductive performance and quality of semen, hence a boon to reproduction and production in rabbit farming industry. DOI: 10.1007/s11250-019-01808-2 PMID: 30659457 [Indexed for MEDLINE]
2. Trop Anim Health Prod. 2012 Apr;44(4):843-7. doi: 10.1007/s11250-011-9976-0. Epub 2011 Sep 11. Evaluation of the metabolizable energy value for growing lambs of the Mucuna pruriens seed and the whole pod. García-Galván A(1), Belmar-Casso R, Sarmiento-Franco L, Sandoval-Castro CA. Author information: (1)Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, P.O. Box 4-116, Merida, Yucatán 97100, Mexico. Whole pod and seeds of velvet bean (Mucuna pruriens) were included in diets for growing sheep used to validate previously estimated ME values of 9.7 MJ and 12.6 MJ for whole pod and seed respectively. Twenty-four lambs, 15 females and nine males of 18.7 ± 2.4 kg average weight, were allocated in three treatments using a completely randomized block design with eight replicates per treatment. Each group was given a diet with a ratio of 60% of Napier grass (Pennisetum purpureum) and 40% of a supplement with the addition of 0%, 50% whole pod or 66% of M. pruriens seeds, for TI, TII and TIII respectively. Diets were formulated to meet the requirements for 100-g daily live weight gain (LWG). The total dry matter intake (836 g a(-1) d(-1), forage + supplement), LWG (90 g a(-1) d(-1)) and feed conversion (9.66 kg DM/kg LWG) of lambs from TIII were lower (P < 0.05) compared to 941 g, 121 g, and 7.78 kg DM/kg LWG from TII and 976 g, 132 g and 7.50 kg DM/kg LWG from TI respectively. No difference was found (P > 0.05) between TI and TII in the three evaluated variables. The ME values of whole pod and seeds of M. pruriens used in this work were validated. It was concluded that M. pruriens can be included as a component in diets for growing sheep, as a partial replacement of conventional feedstuffs. DOI: 10.1007/s11250-011-9976-0 PMID: 21909932 [Indexed for MEDLINE]
3. PLoS One. 2024 Jul 18;19(7):e0307034. doi: 10.1371/journal.pone.0307034. eCollection 2024. The effect of photobiomodulation on histamine and Mucuna pruriens-induced pruritus, hyperknesis and alloknesis in healthy volunteers: A double-blind, randomized, sham-controlled study. Lang-Illievich K(1)(2), Klivinyi C(1), Schulze-Bauer H(1), Elhelali A(3), Bornemann-Cimenti H(1). Author information: (1)Department of Anaesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria. (2)Department of Anesthesia and Intensive Care Medicine, Klinik Güssing, Güssing, Austria. (3)Department of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, Maryland, United States of America. BACKGROUND: Photobiomodulation, also referred to as Low-Level Light Therapy (LLLT), has emerged as a promising intervention for pruritus, a prevalent and often distressing symptom. OBJECTIVES: This study investigated the efficacy of low-level light therapy (LLLT) in alleviating pruritus, hyperknesis, and alloknesis induced by histamine and Mucuna pruriens. METHODS: In a double-blind, randomized, sham-controlled trial with a split-body design, healthy volunteers underwent 6 minutes of LLLT and sham treatments in separate upper back quadrants. The histamine model was applied to the upper quadrants, and Mucuna pruriens to the lower quadrants. Pruritus intensity, alloknesis, hyperknesis, flare area, and skin temperature were measured pre and post treatment. RESULTS: Seventeen individuals (eight females, nine males) participated in the study. In the histamine model, LLLT notably reduced itch intensity (difference = 13.9 (95% CI: 10.5 - 17.4), p = 0.001), alloknesis (difference = 0.80 (95% CI: 0.58-1.02), p = 0.001), and hyperknesis (difference = 0.48 (95% CI: 0.09-0.86), p = 0.01). Skin temperature changes were not significantly different between the two groups (difference = -2.0 (95% CI: -6.7-2.6), p = 0.37). For the Mucuna pruriens model, no significant differences were observed in any measures, including itch intensity (difference = 0.8 (95% CI: -2.3 - 3.8), p = 0.61) hyperknesis (difference = 0.08 (95% CI: -0.06-0.33), p = 0.16) and alloknesis (difference = 0. 0.09 (95% CI: -0.08-0.256), p = 0.27). CONCLUSIONS: LLLT effectively reduced histamine-induced pruritus, alloknesis, and hyperknesis; however, LLLT was ineffective against Mucuna pruriens-induced pruritus. Further investigations are required to determine LLLT's effectiveness of LLLT in various pruritus models. Copyright: © 2024 Lang-Illievich et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. DOI: 10.1371/journal.pone.0307034 PMCID: PMC11257285 PMID: 39024251 [Indexed for MEDLINE] Conflict of interest statement: The authors have declared that no competing interests exist.
4. Trop Anim Health Prod. 2023 Sep 28;55(5):336. doi: 10.1007/s11250-023-03760-8. Dietary supplementation of low levels of unprocessed Mucuna pruriens utilis seed meal induces mild antinutritional entero-physio-metabolic perturbations without compromising performance and meat quality in finisher broilers. Zungu PN(1), Mthiyane DMN(2)(3), Mazibuko-Mbeje SE(4)(5), Ogwuegbu MC(6)(7). Author information: (1)Department of Animal Science, School of Agricultural Sciences, Faculty of Natural and Agricultural Sciences, North-West University (Mahikeng Campus), Private Bag X 2046, Mmabatho, 2735, South Africa. (2)Department of Animal Science, School of Agricultural Sciences, Faculty of Natural and Agricultural Sciences, North-West University (Mahikeng Campus), Private Bag X 2046, Mmabatho, 2735, South Africa. Doc.Mthiyane@nwu.ac.za. (3)Food Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University (Mahikeng Campus), Mmabatho, 2735, South Africa. Doc.Mthiyane@nwu.ac.za. (4)Department of Biochemistry, North-West University, Mmabatho, 2745, South Africa. (5)Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131, Ancona, Italy. (6)Food Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University (Mahikeng Campus), Mmabatho, 2735, South Africa. (7)Department of Animal Science, Faculty of Agriculture, University of Nigeria, Nsukka, Enugu State, 410001, Nigeria. The rapidly growing world human population accentuates the need for improved production especially of protein-rich food. Broiler meat production offers opportunity to ensure security of this food. However, the production of modern broilers is not only limited by high feed costs due to dietary use of expensive energy and protein sources but also their meat possesses undesirable quality attributes. This study thus examined the effect of dietary Mucuna pruriens utilis seed meal (MSM) on growth performance, blood profile, carcass traits, and meat quality in finisher broiler chickens. In a completely randomised design (CRD), 320 21-day-old chicks were randomly allocated to 32 pens in which they were allotted 4 dietary treatments with 0, 2.5, 5, and 10% MSM, each with 8 replicate pens of 10 birds, for 28 days. Growth performance, carcass characteristics, internal organs, haemato-biochemistry, and meat quality were measured. Results showed that dietary MSM did not affect (P > 0.05) broiler performance, weights, and lengths of carcass cuts and internal organs, haematology, and meat quality. The only exception was MSM-induced increase in duodenal weight (linear, P < 0.05) and serum phosphorus (quadratic, P = 0.05) in contrast to a decrease in procalcitonin (quadratic, P < 0.01) and serum levels of total protein (linear, P < 0.05; and quadratic, P < 0.01), albumin (quadratic, P < 0.05), and bilirubin (quadratic, P = 0.001). Therefore, MSM could be supplemented up to 10% without compromising performance, carcass traits, internal organs, haemato-biochemistry, and meat quality in finisher broiler diets. © 2023. The Author(s). DOI: 10.1007/s11250-023-03760-8 PMCID: PMC10539458 PMID: 37770670 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no competing of interests.
5. Trop Anim Health Prod. 2019 May;51(4):867-877. doi: 10.1007/s11250-018-1767-4. Epub 2018 Dec 7. Effects of supplementing herbaceous forage legume pellets on growth indices and blood profile of West African dwarf sheep fed Guinea grass. Ojo VOA(1), Oyaniran DK(2), Ogunsakin AO(2), Aderinboye RY(3), Adelusi OO(3), Odusoga FS(2). Author information: (1)Department of Pasture and Range Management, Federal University of Agriculture, Abeokuta, P. M. B. 2240, Nigeria. ojovoa@funaab.edu.ng. (2)Department of Pasture and Range Management, Federal University of Agriculture, Abeokuta, P. M. B. 2240, Nigeria. (3)Department of Animal Nutrition, Federal University of Agriculture, Abeokuta, P. M. B. 2240, Nigeria. Twenty West African dwarf (WAD) rams with average body weight of 12.43 ± 0.5 kg were used for the experiment that lasted 84 days to investigate the effects of supplementing herbaceous forage legume pellets on weight change and blood profile of animals fed Panicum maximum basal diet. Sole Panicum maximum served as the control diet and three other experimental diets were P. maximum supplemented with Lablab purpureus pellets, P. maximum supplemented with Calopogonium mucunoides pellets and P. maximum supplemented with Mucuna pruriens pellets constituted the four treatments which were arranged in a completely randomised design. The rams were divided into four groups of five animals each and were balanced for variation in live weight before they were assigned the experimental diets. Panicum maximum was offered to the animals ad libitum and legume pellets were supplemented. Significant differences (P < 0.05) were observed in weight gain of the rams. Those fed the control diet had the lowest value of 41.88 g/day while rams supplemented L. purpureus pellets had the highest value (83.66 g/day). Haematological parameters, leucocyte values and serum biochemical indices of WAD rams were significantly (P < 0.05) different across the dietary treatments at the final stage of the trial. The values for red blood cells, haemoglobin concentration, packed cell volume and mean corpuscular haemoglobin decreased slightly in rams supplemented with M. pruriens pellets. Reduction of serum biochemical parameters was also noticed in rams supplemented with M. pruriens pellets. It can be concluded that L. purpureus pellets ranked the best among the herbaceous legume pellets as supplemental feed for West African dwarf sheep resulting in higher weight gain and better feed conversion efficiency with no deleterious effect on blood profile. DOI: 10.1007/s11250-018-1767-4 PMID: 30536120 [Indexed for MEDLINE]
6. Parkinsonism Relat Disord. 2018 Apr;49:60-66. doi: 10.1016/j.parkreldis.2018.01.014. Epub 2018 Jan 11. Daily intake of Mucuna pruriens in advanced Parkinson's disease: A 16-week, noninferiority, randomized, crossover, pilot study. Cilia R(1), Laguna J(2), Cassani E(3), Cereda E(4), Raspini B(3), Barichella M(3), Pezzoli G(3). Author information: (1)Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy. Electronic address: roberto.cilia@gmail.com. (2)Neurology Clinic, Clinica Niño Jesus, Santa Cruz, Bolivia. (3)Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy. (4)Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. BACKGROUND: Thousands of individuals with Parkinson's disease (PD) in low-income countries have limited access to marketed levodopa preparations. Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in tropical areas, may be a sustainable alternative therapy for indigent patients. Single-dose intake of MP proved noninferior to marketed levodopa preparations. METHODS: Fourteen PD patients with motor fluctuations and dyskinesias received MP powder (obtained from roasted seeds) and marketed levodopa/carbidopa (LD/CD) in a randomized order and crossover design over a 16-week period. Efficacy measures were changes in quality of life, motor and non-motor symptoms, and time with good mobility without troublesome dyskinesias. Safety measures included tolerability, frequency of adverse events, changes in laboratory indices and electrocardiogram. RESULTS: Daily intake of MP was associated with a variable clinical response, especially in terms of tolerability. Seven patients (50%) discontinued MP prematurely due to either gastrointestinal side-effects (n = 4) or progressive worsening of motor performance (n = 3), while nobody discontinued during the LD/CD phase. In those who tolerated MP, clinical response to MP was similar to LD/CD on all efficacy outcome measures. Patients who dropped out entered a study extension using MP supernatant water (median[IQR], 16 [7-20] weeks), which was well tolerated. CONCLUSIONS: The overall benefit provided by MP on the clinical outcome was limited by tolerability issues, as one could expect by the relatively rapid switch from LD/CD to levodopa alone in advanced PD. Larger parallel-group studies are needed to identify appropriate MP formulation (e.g. supernatant water), titration scheme and maintenance dose to minimize side-effects in the long-term. CLINICAL TRIALS. GOV IDENTIFIER: NCT02680977. Copyright © 2018 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.parkreldis.2018.01.014 PMID: 29352722 [Indexed for MEDLINE]
7. Neurology. 2017 Aug 1;89(5):432-438. doi: 10.1212/WNL.0000000000004175. Epub 2017 Jul 5. Mucuna pruriens in Parkinson disease: A double-blind, randomized, controlled, crossover study. Cilia R(1), Laguna J(2), Cassani E(2), Cereda E(2), Pozzi NG(2), Isaias IU(2), Contin M(2), Barichella M(2), Pezzoli G(2). Author information: (1)From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS-Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy. roberto.cilia@gmail.com. (2)From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS-Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy. OBJECTIVE: To investigate whether Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in all tropical areas worldwide, may be used as alternative source of levodopa for indigent individuals with Parkinson disease (PD) who cannot afford long-term therapy with marketed levodopa preparations. METHODS: We investigated efficacy and safety of single-dose intake of MP powder from roasted seeds obtained without any pharmacologic processing. Eighteen patients with advanced PD received the following treatments, whose sequence was randomized: (1) dispersible levodopa at 3.5 mg/kg combined with the dopa-decarboxylase inhibitor benserazide (LD+DDCI; the reference treatment); (2) high-dose MP (MP-Hd; 17.5 mg/kg); (3) low-dose MP (MP-Ld; 12.5 mg/kg); (4) pharmaceutical preparation of LD without DDCI (LD-DDCI; 17.5 mg/kg); (5) MP plus benserazide (MP+DDCI; 3.5 mg/kg); (6) placebo. Efficacy outcomes were the change in motor response at 90 and 180 minutes and the duration of on state. Safety measures included any adverse event (AE), changes in blood pressure and heart rate, and the severity of dyskinesias. RESULTS: When compared to LD+DDCI, MP-Ld showed similar motor response with fewer dyskinesias and AEs, while MP-Hd induced greater motor improvement at 90 and 180 minutes, longer ON duration, and fewer dyskinesias. MP-Hd induced less AEs than LD+DDCI and LD-DDCI. No differences in cardiovascular response were recorded. CONCLUSION: Single-dose MP intake met all noninferiority efficacy and safety outcome measures in comparison to dispersible levodopa/benserazide. Clinical effects of high-dose MP were similar to levodopa alone at the same dose, with a more favorable tolerability profile. CLINICALTRIALSGOV IDENTIFIER: NCT02680977. Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. DOI: 10.1212/WNL.0000000000004175 PMCID: PMC5539737 PMID: 28679598 [Indexed for MEDLINE]
8. Curr Neurol Neurosci Rep. 2014 Jun;14(6):451. doi: 10.1007/s11910-014-0451-y. Mechanisms for alternative treatments in Parkinson's disease: acupuncture, tai chi, and other treatments. Ghaffari BD(1), Kluger B. Author information: (1)Department of Neurology, University of Colorado School of Medicine, Academic Office 1, Mail Stop B-185 12631 East 17th Avenue, Aurora, CO, 80045, USA, bijan.ghaffari@ucdenver.edu. At least 40% of patients with Parkinson's disease (PD) use one or more forms of alternative therapy (AT) to complement standard treatments. This article reviews the commonest forms of AT for PD, including acupuncture, tai chi, yoga, mindfulness, massage, herbal medicine, and cannabis. We discuss the current evidence for the clinical efficacy of each AT and discuss potential mechanisms, including those suggested by animal and human studies. With a few notable exceptions, none of the treatments examined were investigated rigorously enough to draw definitive conclusions about efficacy or mechanism. Tai chi, acupuncture, Mucuna pruriens, cannabinoids, and music therapy have all been proposed to work through specific mechanisms, although current evidence is insufficient to support or refute these claims, with the possible exception of Mucuna pruriens (which contains levodopa). It is likely that most ATs predominantly treat PD patients through general mechanisms, including placebo effects, stress reduction, and improved mood and sleep, and AT may provide patients with a greater locus of control regarding their illness. DOI: 10.1007/s11910-014-0451-y PMID: 24760476 [Indexed for MEDLINE]
9. J Ethnopharmacol. 2010 Feb 17;127(3):669-73. doi: 10.1016/j.jep.2009.12.006. Epub 2009 Dec 5. Effect of feeding Mucuna pruriens on helminth parasite infestation in lambs. Huisden CM(1), Adesogan AT, Gaskin JM, Courtney CH, Raji AM, Kang T. Author information: (1)Department of Animal Sciences, Institute of Food and Agricultural Science, University of Florida, Gainesville, FL 32611, USA. ETHNOPHARMACOLOGICAL RELEVANCE: Mucuna pruriens is a tropical legume anecdotally reputed to have anthelmintic properties. This study was conducted to examine the validity of such claims. AIM OF THE STUDY: The aim of this study was to determine if ingestion of Mucuna seeds reduces helminth parasite infestation in lambs. MATERIALS AND METHODS: Thirty-six Dorper x Katahdin ram lambs were assigned to three treatments, a cottonseed meal based control diet, a diet in which Mucuna replaced cottonseed meal and the control diet with levamisole (7.5mg/kg body weight) administration. All diets were isonitrogenous and isocaloric. The 12 lambs in each treatment were assigned randomly to 4 pens, each containing 3 lambs. Lambs were trickle infected three times per week by gavage with infectious Haemonchus contortus larvae (2000 larvae/lamb) for 3 weeks. RESULTS: Levamisole treatment decreased fecal egg counts by 87% and abomasal worm counts by 83%. Mucuna intake did not statistically affect fecal egg counts or abomasal worm counts, though numerical (P>0.10) reductions of 7.4% and 18.1%, respectively were evident. Anemia indicators, feed intake, and lamb growth were unaffected by treatment. CONCLUSIONS: Levamisole reduced the Haemonchus parasite burden in lambs significantly but feeding Mucuna reduced the burden by levels unlikely to eliminate the clinical effects of parasitism. Copyright 2009 Elsevier Ireland Ltd. All rights reserved. DOI: 10.1016/j.jep.2009.12.006 PMID: 19969060 [Indexed for MEDLINE]
10. J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1672-7. doi: 10.1136/jnnp.2003.028761. Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study. Katzenschlager R(1), Evans A, Manson A, Patsalos PN, Ratnaraj N, Watt H, Timmermann L, Van der Giessen R, Lees AJ. Author information: (1)National Hospital for Neurology and Neurosurgery, London, UK. BACKGROUND: The seed powder of the leguminous plant, Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine for diseases including parkinsonism. We have assessed the clinical effects and levodopa (L-dopa) pharmacokinetics following two different doses of mucuna preparation and compared them with standard L-dopa/carbidopa (LD/CD). METHODS: Eight Parkinson's disease patients with a short duration L-dopa response and on period dyskinesias completed a randomised, controlled, double blind crossover trial. Patients were challenged with single doses of 200/50 mg LD/CD, and 15 and 30 g of mucuna preparation in randomised order at weekly intervals. L-dopa pharmacokinetics were determined, and Unified Parkinson's Disease Rating Scale and tapping speed were obtained at baseline and repeatedly during the 4 h following drug ingestion. Dyskinesias were assessed using modified AIMS and Goetz scales. RESULTS: Compared with standard LD/CD, the 30 g mucuna preparation led to a considerably faster onset of effect (34.6 v 68.5 min; p = 0.021), reflected in shorter latencies to peak L-dopa plasma concentrations. Mean on time was 21.9% (37 min) longer with 30 g mucuna than with LD/CD (p = 0.021); peak L-dopa plasma concentrations were 110% higher and the area under the plasma concentration v time curve (area under curve) was 165.3% larger (p = 0.012). No significant differences in dyskinesias or tolerability occurred. CONCLUSIONS: The rapid onset of action and longer on time without concomitant increase in dyskinesias on mucuna seed powder formulation suggest that this natural source of L-dopa might possess advantages over conventional L-dopa preparations in the long term management of PD. Assessment of long term efficacy and tolerability in a randomised, controlled study is warranted. DOI: 10.1136/jnnp.2003.028761 PMCID: PMC1738871 PMID: 15548480 [Indexed for MEDLINE]
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