NAC (N-아세틸시스테인)

Unlocking the potential of antioxidant supplementation with n-acetylcysteine to improve seminal parameters and analysis of its safety: a systematic review and meta-analysis of randomized controlled trials.

1. Arch Ital Urol Androl. 2025 Mar 28;97(1):13750. doi: 10.4081/aiua.2025.13750. Epub 2025 Mar 24. Unlocking the potential of antioxidant supplementation with n-acetylcysteine to improve seminal parameters and analysis of its safety: a systematic review and meta-analysis of randomized controlled

Systematic review and network meta-analysis of efficacy and safety of interventions for preventing anti-tuberculosis drug induced liver injury.

2. Sci Rep. 2023 Nov 14;13(1):19880. doi: 10.1038/s41598-023-46565-3. Systematic review and network meta-analysis of efficacy and safety of interventions for preventing anti-tuberculosis drug induced liver injury. Akkahadsee P(1), Sawangjit R(2), Phumart P(3), Chaiyakunapruk N(4)(5), Sakloetsaku

Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.

3. World J Biol Psychiatry. 2022 Jul;23(6):424-455. doi: 10.1080/15622975.2021.2013041. Epub 2022 Mar 21. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Networ

The efficacy of nutritional supplements for the adjunctive treatment of schizophrenia in adults: A systematic review and network meta-analysis.

4. Psychiatry Res. 2022 May;311:114500. doi: 10.1016/j.psychres.2022.114500. Epub 2022 Mar 7. The efficacy of nutritional supplements for the adjunctive treatment of schizophrenia in adults: A systematic review and network meta-analysis. Xu X(1), Shao G(2), Zhang X(1), Hu Y(1), Huang J(3), Su Y(

Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis.

5. Gynecol Endocrinol. 2020 Mar;36(3):204-210. doi: 10.1080/09513590.2019.1689553. Epub 2019 Nov 21. Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis. Song Y(1), Wang H(1), Huang H(1), Zhu Z(1). Author information: (1)Department of Obstetrics and G

Protective effects of anti-oxidant supplementations on contrast-induced nephropathy after coronary angiography: an updated and comprehensive meta-analysis and systematic review.

6. Kardiol Pol. 2016;74(7):610-26. doi: 10.5603/KP.a2016.0007. Epub 2016 Jan 18. Protective effects of anti-oxidant supplementations on contrast-induced nephropathy after coronary angiography: an updated and comprehensive meta-analysis and systematic review. Ali-Hasan-Al-Saegh S, Mirhosseini SJ(

Efficacy Of N-Acetyl-Cysteine as Adjuvant Therapy for Diabetic Foot Osteomyelitis: An Open-Label Randomized Controlled Trial.

7. Arch Iran Med. 2025 May 1;28(5):257-263. doi: 10.34172/aim.33355. Epub 2025 May 1. Efficacy Of N-Acetyl-Cysteine as Adjuvant Therapy for Diabetic Foot Osteomyelitis: An Open-Label Randomized Controlled Trial. Hooshmand Gharabagh L(1), Heydaroghli M(2), Esmaeili A(3)(4). Author information: (

New Approach Combination-Dosed Therapy for Nonalcoholic Steatohepatitis Versus Vitamin E: A Randomized Controlled Trial.

8. Clin Ther. 2025 Aug;47(8):e19-e30. doi: 10.1016/j.clinthera.2025.05.006. Epub 2025 Jun 6. New Approach Combination-Dosed Therapy for Nonalcoholic Steatohepatitis Versus Vitamin E: A Randomized Controlled Trial. Zakaria AY(1), Badawi R(2), Osama H(3), Abdelrahman MA(3), El-Kalaawy AM(4). Auth

The effects of N-acetyl cysteine on intrinsic functional connectivity and neural alcohol cue reactivity in treatment-seeking individuals with alcohol use disorder: a preliminary study.

9. Psychopharmacology (Berl). 2025 Jan;242(1):149-160. doi: 10.1007/s00213-024-06656-z. Epub 2024 Aug 5. The effects of N-acetyl cysteine on intrinsic functional connectivity and neural alcohol cue reactivity in treatment-seeking individuals with alcohol use disorder: a preliminary study. Logge

Effect of N-acetyl cysteine in children with metabolic dysfunction-associated steatotic liver disease-A pilot study.

10. J Pediatr Gastroenterol Nutr. 2024 Sep;79(3):652-660. doi: 10.1002/jpn3.12312. Epub 2024 Jul 8. Effect of N-acetyl cysteine in children with metabolic dysfunction-associated steatotic liver disease-A pilot study. Babu Balagopal P(1)(2), Kohli R(3), Uppal V(4), Averill L(4), Shah C(1), McGoo

Safety and tolerability of topiramate and N-acetyl cysteine combination in individuals with alcohol use disorder: a 12 week, randomized, double-blind, pilot study.

11. Alcohol Alcohol. 2024 Jan 17;59(2):agad082. doi: 10.1093/alcalc/agad082. Safety and tolerability of topiramate and N-acetyl cysteine combination in individuals with alcohol use disorder: a 12 week, randomized, double-blind, pilot study. Tiouririne NA(1), Kalelioglu T(1), Seneviratne C(2)(3),

[Efficacy of intratympanic infiltration of N-acetyl cysteine in cisplatin ototoxicity].

12. Rev Med Inst Mex Seguro Soc. 2023 Sep 18;61(Suppl 2):S318-S322. [Efficacy of intratympanic infiltration of N-acetyl cysteine in cisplatin ototoxicity]. [Article in Spanish; Abstract available in Spanish from the publisher] Rosas-Gutiérrez GDC(1), Fernández-Hernández JP(2), Olea-González AI(3

Pre-medication with simethicone and N-acetyl cysteine for improving mucosal visibility during upper gastrointestinal endoscopy: A randomized controlled trial.

13. Indian J Gastroenterol. 2024 Oct;43(5):986-994. doi: 10.1007/s12664-023-01459-0. Epub 2023 Oct 18. Pre-medication with simethicone and N-acetyl cysteine for improving mucosal visibility during upper gastrointestinal endoscopy: A randomized controlled trial. Nabi Z(1), Vamsi M(2), Goud R(2),

N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial.

14. Rev Recent Clin Trials. 2023;18(4):288-299. doi: 10.2174/0115748871250545230919055109. N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial. Heidari B(1), Seyedian ZA(2), Mehrpoo

N acetylcysteine in the treatment of alcohol use disorder: a randomized, double-blind, placebo-controlled trial.

15. Alcohol Alcohol. 2023 Sep 9;58(5):553-560. doi: 10.1093/alcalc/agad044. N acetylcysteine in the treatment of alcohol use disorder: a randomized, double-blind, placebo-controlled trial. Morley KC(1), Peruch S(1), Adams C(1), Towers E(1), Tremonti C(2), Watt J(2), Jamshidi N(1)(2), Haber PS(1)

Effects of Selenium and/or N-Acetyl-Cysteine Supplementation on Nonthyroidal Illness Syndrome in Hemodialysis Patients: A Factorial Randomized Controlled Trial.

6. Pharmacology. 2022;107(9-10):480-485. doi: 10.1159/000525094. Epub 2022 Jun 10. Effects of Selenium and/or N-Acetyl-Cysteine Supplementation on Nonthyroidal Illness Syndrome in Hemodialysis Patients: A Factorial Randomized Controlled Trial. Shahreki E(1), Kaykhaei MA(2), Mosallanezhad Z(3), A

Controlled-release hybrid hydrogels delivering synergistic N-acetyl cysteine, ibuprofen, and progesterone combinations for enhanced peripheral nerve regeneration.

22. Int J Pharm. 2026 Jan 5;687:126423. doi: 10.1016/j.ijpharm.2025.126423. Epub 2025 Nov 20. Controlled-release hybrid hydrogels delivering synergistic N-acetyl cysteine, ibuprofen, and progesterone combinations for enhanced peripheral nerve regeneration. Burke G(1), Ebrahimi F(1), Fehrenbach

Withaferin A, a natural thioredoxin reductase 1 (TrxR1) inhibitor, synergistically enhances the antitumor efficacy of sorafenib through ROS-mediated ER stress and DNA damage in hepatocellular carcinoma cells.

7. Phytomedicine. 2024 Jun;128:155317. doi: 10.1016/j.phymed.2023.155317. Epub 2023 Dec 25. Withaferin A, a natural thioredoxin reductase 1 (TrxR1) inhibitor, synergistically enhances the antitumor efficacy of sorafenib through ROS-mediated ER stress and DNA damage in hepatocellular carcinoma ce

Disulfiram potentiates docetaxel cytotoxicity in breast cancer cells through enhanced ROS and autophagy.

10. Pharmacol Rep. 2020 Dec;72(6):1749-1765. doi: 10.1007/s43440-020-00122-1. Epub 2020 Jul 2. Disulfiram potentiates docetaxel cytotoxicity in breast cancer cells through enhanced ROS and autophagy. Swetha KL(1), Sharma S(1), Chowdhury R(2), Roy A(3). Author information: (1)Department of Pharm

Icariside II overcomes BRAF inhibitor resistance in melanoma by inducing ROS production and inhibiting MITF.

4. Oncol Rep. 2020 Jul;44(1):360-370. doi: 10.3892/or.2020.7582. Epub 2020 Apr 15. Icariside II overcomes BRAF inhibitor resistance in melanoma by inducing ROS production and inhibiting MITF. Liu X(1), Li Z(1), Li M(1), Chai J(1), He S(1), Wu J(1), Xu J(1). Author information: (1)Department of D

Role of N-acetyl cysteine and acetyl-l-carnitine combination treatment on DNA-damage-related genes induced by radiation in HEI-OC1 cells.

44. Int J Radiat Biol. 2019 Mar;95(3):298-306. doi: 10.1080/09553002.2019.1547847. Epub 2019 Feb 6. Role of N-acetyl cysteine and acetyl-l-carnitine combination treatment on DNA-damage-related genes induced by radiation in HEI-OC1 cells. Düzenli U(1), Altun Z(2), Olgun Y(3), Aktaş S(2), Pamukoğl

Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells.

26. Biochem Biophys Res Commun. 2018 Feb 12;496(3):998-1005. doi: 10.1016/j.bbrc.2018.01.003. Epub 2018 Jan 2. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Xu Y(1), Gao CC(1), Pan ZG(1), Zhou CW(2). Author information: (1)Huai'an Fir

Carnosine and N-acetyl cysteine protect against sodium nitrite-induced oxidative stress in rat blood.

29. Cell Biol Int. 2018 Mar;42(3):281-293. doi: 10.1002/cbin.10893. Epub 2017 Nov 15. Carnosine and N-acetyl cysteine protect against sodium nitrite-induced oxidative stress in rat blood. Ansari FA(1), Mahmood R(1). Author information: (1)Faculty of Life Sciences, Department of Biochemistry, Al

Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine.

12. Sci Rep. 2017 Mar 13;7:44460. doi: 10.1038/srep44460. Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine. Wongjaikam S(1)(2)(3), Kumfu S(1)(2)(3), Khamseekaew J(1)(2)(3), Chattipakorn SC(1)(3)(4), Ch

Combination of 2-deoxy d-glucose and metformin for synergistic inhibition of non-small cell lung cancer: A reactive oxygen species and P-p38 mediated mechanism.

6. Biomed Pharmacother. 2016 Dec;84:1575-1584. doi: 10.1016/j.biopha.2016.10.037. Epub 2016 Nov 5. Combination of 2-deoxy d-glucose and metformin for synergistic inhibition of non-small cell lung cancer: A reactive oxygen species and P-p38 mediated mechanism. Hou XB(1), Li TH(2), Ren ZP(1), Liu

Combined Iron Chelator and Antioxidant Exerted Greater Efficacy on Cardioprotection Than Monotherapy in Iron-Overloaded Rats.

25. PLoS One. 2016 Jul 18;11(7):e0159414. doi: 10.1371/journal.pone.0159414. eCollection 2016. Combined Iron Chelator and Antioxidant Exerted Greater Efficacy on Cardioprotection Than Monotherapy in Iron-Overloaded Rats. Wongjaikam S(1)(2)(3), Kumfu S(1)(2)(3), Khamseekaew J(1)(2)(3), Sripetchwa

Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells.

33. Biochimie. 2022 Jul;198:155-166. doi: 10.1016/j.biochi.2022.04.014. Epub 2022 Apr 30. Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells. Jung YY(1), Baek SH(2), Ha IJ(3), Ahn KS(4). Author information: (1)Department of Science in Korean Medicine, Kyung

Pharmacokinetics and Safety of Single and Multiple Doses of Oral N-Acetylcysteine in Healthy Chinese and Caucasian Volunteers: An Open-Label, Phase I Clinical Study.

16. Adv Ther. 2021 Jan;38(1):468-478. doi: 10.1007/s12325-020-01542-4. Epub 2020 Nov 4. Pharmacokinetics and Safety of Single and Multiple Doses of Oral N-Acetylcysteine in Healthy Chinese and Caucasian Volunteers: An Open-Label, Phase I Clinical Study. Papi A(1), Di Stefano AFD(2), Radicioni M

Premedication in upper gastrointestinal endoscopy to improve mucosal visualization. A systematic review.

26. Rev Gastroenterol Peru. 2024 Oct-Dec;44(4):346-353. Premedication in upper gastrointestinal endoscopy to improve mucosal visualization. A systematic review. [Article in English] Linares-Ramírez JD(1), Córdoba AC(1), Calderón-Franco CH(1), Aponte-Martín DM(1), Dávila F(1), Sabbagh LC(1). Au

From tugs to treatments: a systematic review on pharmacological interventions for trichotillomania.

4. Clin Exp Dermatol. 2024 Jul 19;49(8):774-782. doi: 10.1093/ced/llae052. From tugs to treatments: a systematic review on pharmacological interventions for trichotillomania. Ghani H(1), Podwojniak A(2), Tan IJ(3), Fliorent R(2), Jafferany M(4). Author information: (1)Northwestern University Dep