NMN

Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

1. Nutrients. 2026 Mar 11;18(6):890. doi: 10.3390/nu18060890. Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Zhang M(1), Chen Y(1), Jiang N(1), Zeng J(1), Zhang J(1), Wu C(1), Liu Y(1), Nie Z(1), Ya

NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence.

2. Ageing Res Rev. 2026 Apr;116:103057. doi: 10.1016/j.arr.2026.103057. Epub 2026 Feb 6. NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence. Gallagher C(1), Emmanuel OO(2). Author information: (1)Allure Management, 150 Allend

NMN supplementation as a strategy to improve oocyte quality: a systematic review and transcriptomic analysis.

3. J Assist Reprod Genet. 2026 Jan;43(1):51-65. doi: 10.1007/s10815-025-03720-1. Epub 2025 Oct 29. NMN supplementation as a strategy to improve oocyte quality: a systematic review and transcriptomic analysis. Noh H(1), Sen Gupta S(1), Seshadri S(1), Viñals Gonzalez X(2)(3). Author information:

The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.

4. J Cachexia Sarcopenia Muscle. 2025 Jun;16(3):e13799. doi: 10.1002/jcsm.13799. The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis. Prokopidis K(1), Moriarty F(2), Bahat G(3), McLean J(4), Church DD(5), Patel HP(6)(

Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials.

5. Curr Diab Rep. 2024 Nov 12;25(1):4. doi: 10.1007/s11892-024-01557-z. Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials. Chen F(#)(1), Zhou D(#)(1), Kong AP(2), Yim NT(3), Dai S(4)(5)(6), Chen

Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach.

6. J Alzheimers Dis. 2024;101(s1):S467-S477. doi: 10.3233/JAD-231277. Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach. Alghamdi M(1)(2), Braidy N(1). Author information: (1)Centre for Healthy Brain Ageing, School of Psychiatry, University of New South

Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

7. Curr Pharm Biotechnol. 2025;26(13):2141-2152. doi: 10.2174/0113892010306242240808094303. Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Wang JP(1)(2

Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials.

8. Crit Rev Food Sci Nutr. 2025;65(22):4382-4400. doi: 10.1080/10408398.2024.2387324. Epub 2024 Aug 8. Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials. Zhang J(1), Poo

Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis.

9. Front Public Health. 2023 Oct 26;11:1287421. doi: 10.3389/fpubh.2023.1287421. eCollection 2023. Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis. Sun X(1), Su L(2)(3), Bu T(1)(3), Zhang Y(4). Auth

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.

10. Exp Gerontol. 2020 Apr;132:110831. doi: 10.1016/j.exger.2020.110831. Epub 2020 Jan 7. NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis. Braidy N(1), Liu Y(2). Author information: (1)Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wal

Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise.

11. J Int Soc Sports Nutr. 2026 Dec 31;23(1):2632284. doi: 10.1080/15502783.2026.2632284. Epub 2026 Feb 18. Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise. Yang DL(1), Chao KC(2), Yang HT(1)(2), Chen KH(1), Dewi L(3), Condello G(4), Ye

The differential impact of three different NAD(+) boosters on circulatory NAD and microbial metabolism in humans.

12. Nat Metab. 2026 Jan;8(1):62-73. doi: 10.1038/s42255-025-01421-8. Epub 2026 Jan 15. The differential impact of three different NAD(+) boosters on circulatory NAD and microbial metabolism in humans. Christen S(1), Redeuil K(1), Goulet L(1), Giner MP(1), Breton I(1), Rota R(1), Frézal A(1), Na

Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study.

13. Geroscience. 2024 Oct;46(5):4671-4688. doi: 10.1007/s11357-024-01204-1. Epub 2024 May 24. Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study. Morif

Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial.

14. Sci Rep. 2023 Feb 16;13(1):2786. doi: 10.1038/s41598-023-29787-3. Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial. Katayoshi T(1), Uehata S(1), Nakashima N(1)

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.

15. J Clin Endocrinol Metab. 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study. Pencina KM(1), Valderrabano R(1), Wipper B(1), Orkaby AR(2), Reid KF(1), Storer T(1),

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.

13. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clini

Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study.

4. Geriatr Gerontol Int. 2023 Jan;23(1):38-43. doi: 10.1111/ggi.14513. Epub 2022 Nov 28. Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study. Akasaka H(1), Nakagami H(2), Sugimoto K(3), Y

Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.

46. Sci Rep. 2022 Aug 24;12(1):14442. doi: 10.1038/s41598-022-18272-y. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Fukamizu Y(1), Uchida Y(1), Shigekawa A(1), Sato T(1), Kosaka H(2), Sakurai T(3). Author information: (1)Research and Dev

Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study.

29. Nutrients. 2022 Feb 11;14(4):755. doi: 10.3390/nu14040755. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Kim M(1), Seol J(2)(3)(4), Sato T(5), Fukamizu

MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults.

6. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):90-96. doi: 10.1093/gerona/glac049. MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults

High-Level Production of NMN in Escherichia coli Through Co-Utilization of Glucose and Glycerol.

25. Microorganisms. 2026 Apr 16;14(4):897. doi: 10.3390/microorganisms14040897. High-Level Production of NMN in Escherichia coli Through Co-Utilization of Glucose and Glycerol. Gan J(1)(2), Chen X(1), He Y(1), Zhang Y(3), Zhong J(1)(2), Dong Z(1). Author information: (1)State Key Laboratory of M

An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT.

45. Redox Biol. 2026 Apr 24;93:104191. doi: 10.1016/j.redox.2026.104191. Online ahead of print. An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT. Sun Y(1), Han JC(1), Tran K(1), Pham T(2), Zhou Q(3)

Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial.

11. Nat Med. 2026 Apr 29. doi: 10.1038/s41591-026-04366-x. Online ahead of print. Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial. Li H(#)(1)(2), Xu Y(#)(1)(2), Chen Y(#)(1)(2), Ji L(#)(1)(2), Xu Y(#)(1)(2), Zheng W(1)(2), Sun T(1)(2), Fu R(1)(2), Pei X(1

ROS-responsive microneedle patch delivering NMN@Cu/CeO₂ nanozyme for restoring immune microenvironment and mitochondrial homeostasis to potentiate diabetic wound healing.

46. J Nanobiotechnology. 2026 Apr 27. doi: 10.1186/s12951-026-04445-8. Online ahead of print. ROS-responsive microneedle patch delivering NMN@Cu/CeO₂ nanozyme for restoring immune microenvironment and mitochondrial homeostasis to potentiate diabetic wound healing. Wang Y(#)(1), Liang Z(#)(2), X

A Potential Anti-Aging Probiotic: Lactobacillus paracasei JS-3 Extends Lifespan in Caenorhabditis elegans and Modulates the Gut Microbiota in the Elderly.

38. J Nutr Biochem. 2026 Apr 23:110390. doi: 10.1016/j.jnutbio.2026.110390. Online ahead of print. A Potential Anti-Aging Probiotic: Lactobacillus paracasei JS-3 Extends Lifespan in Caenorhabditis elegans and Modulates the Gut Microbiota in the Elderly. Li A(1), Li H(1), Yang L(1), Zhang N(1), W

Histone lactylation maintains bovine early embryo development via regulating embryonic genome activation.

4. J Anim Sci Biotechnol. 2026 Apr 23;17(1):76. doi: 10.1186/s40104-026-01398-8. Histone lactylation maintains bovine early embryo development via regulating embryonic genome activation. Yu W(#)(1), Xia Y(#)(1), Wang W(1), Yang Z(1), Liu Z(1), Gan X(1), Zhang M(1), Zhou B(1), Li Y(1), Zhang Y(2)

SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways.

18. Drug Des Devel Ther. 2026 Apr 15;20:594895. doi: 10.2147/DDDT.S594895. eCollection 2026. SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways. Weiss B(1), Miranda DR(1), Arrazati D(1), Cao R(1), Chen J(2)(3), Liu Y(3)(4), Brown D(1), Marshall

NAD(+) precursor supplementation reverses CD36-mediated lipid accumulation and ferroptosis to restore antitumor function of NK cells in DLBCL.

34. Pharm Sci Adv. 2026 Feb 12;4:100111. doi: 10.1016/j.pscia.2026.100111. eCollection 2026 Dec. NAD(+) precursor supplementation reverses CD36-mediated lipid accumulation and ferroptosis to restore antitumor function of NK cells in DLBCL. Shi L(1), Huang X(1), Han X(2), Ning C(2), Zhao X(2), Li

Structural and biochemical characterization of a novel inhibitor of NMNAT1, the gatekeeper of nuclear NAD(+) biosynthesis.

20. bioRxiv [Preprint]. 2026 Apr 8:2026.04.07.716846. doi: 10.64898/2026.04.07.716846. Structural and biochemical characterization of a novel inhibitor of NMNAT1, the gatekeeper of nuclear NAD(+) biosynthesis. Lansiquot C(1), Wu R(1), Davies JP(1), Song X(1)(2)(3), Kaniskan HÜ(1)(2)(3), Jin J(1

Nicotinamide mononucleotide attenuates hepatic endoplasmic reticulum stress and modulates circadian rhythms in young mice with diet-induced obesity.

46. Nutr Res Pract. 2026 Apr;20(2):220-238. doi: 10.4162/nrp.2026.20.2.220. Epub 2025 Jul 23. Nicotinamide mononucleotide attenuates hepatic endoplasmic reticulum stress and modulates circadian rhythms in young mice with diet-induced obesity. Kwon SY(1)(2), Na K(1)(2), Han Y(1)(2), Song S(1)(2),