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Effect of papain gel pretreatment on the remineralizing potential of casein phosphopeptide-amorphous calcium phosphate fluoride varnish in white spot lesions: A randomized controlled trial.

1. J Indian Soc Pedod Prev Dent. 2026 Jan 1;44(1):113-120. doi: 10.4103/jisppd.jisppd_537_25. Epub 2026 Feb 27. Effect of papain gel pretreatment on the remineralizing potential of casein phosphopeptide-amorphous calcium phosphate fluoride varnish in white spot lesions: A randomized controlled t

Comparison of chemo-mechanical and conventional caries removal methods in 6-to-12-year-old children: Randomized clinical trial.

2. PLoS One. 2026 Jan 16;21(1):e0339771. doi: 10.1371/journal.pone.0339771. eCollection 2026. Comparison of chemo-mechanical and conventional caries removal methods in 6-to-12-year-old children: Randomized clinical trial. Malami AB(1)(2), Adeyemo YI(1)(2), Aminu A(3)(4), Oredugba FA(5). Author

Comparative effectiveness of silver diamine fluoride, papain-based material and CeraBur® in remineralizing or selectively removing infected dentin in primary teeth: A three-month randomized clinical trial.

3. Dent Med Probl. 2026 Jan-Feb;63(1):25-34. doi: 10.17219/dmp/200593. Comparative effectiveness of silver diamine fluoride, papain-based material and CeraBur® in remineralizing or selectively removing infected dentin in primary teeth: A three-month randomized clinical trial. Hasan AT(1), Abbas

One-year clinical and radiographic evaluation of young permanent molars treated with brix 3000 vs. papacárie duo: a randomized controlled clinical trial.

4. BMC Oral Health. 2025 Sep 23;25(1):1421. doi: 10.1186/s12903-025-06715-7. One-year clinical and radiographic evaluation of young permanent molars treated with brix 3000 vs. papacárie duo: a randomized controlled clinical trial. Hassanein PH(1), Samaha AWM(2), Zakaria AS(3), Talaat DM(4). Auth

Clinical performance of two chemomechanical caries removal agents in primary molars: a randomized controlled trial.

5. Eur Arch Paediatr Dent. 2025 Aug;26(4):731-739. doi: 10.1007/s40368-025-01030-9. Epub 2025 Apr 9. Clinical performance of two chemomechanical caries removal agents in primary molars: a randomized controlled trial. Maashi M(1), Elkhodary H(2)(3), Bamashmous N(2), Felemban O(4), Alamoudi N(2).

Comparative evaluation of the clinical effectiveness of chemomechanical (Papacarie) and conventional mechanical caries removal methods in treatment of carious primary molars: a randomized controlled clinical study.

6. BMC Oral Health. 2025 Feb 22;25(1):290. doi: 10.1186/s12903-025-05654-7. Comparative evaluation of the clinical effectiveness of chemomechanical (Papacarie) and conventional mechanical caries removal methods in treatment of carious primary molars: a randomized controlled clinical study. Akind

Does enamel deproteinisation with 10% papain affect shear bond strength of orthodontic adhesives? A randomised controlled trial.

7. J Orthod. 2025 Jun;52(2):183-193. doi: 10.1177/14653125241279461. Epub 2024 Sep 26. Does enamel deproteinisation with 10% papain affect shear bond strength of orthodontic adhesives? A randomised controlled trial. Sharma V(1), Bawaskar N(1), Bhat S(1), Kontham R(1), Chandorikar H(1), Ghodke S

Evaluation of Papacarie®, Carie-Care™, BRIX3000™ and conventional hand instrumentation for caries removal in primary teeth: a randomized control study.

8. J Clin Pediatr Dent. 2024 May;48(3):131-138. doi: 10.22514/jocpd.2024.066. Epub 2024 May 3. Evaluation of Papacarie®, Carie-Care™, BRIX3000™ and conventional hand instrumentation for caries removal in primary teeth: a randomized control study. Gupta N(#)(1), Marwah N(#)(1), Nigam A(1), Vishwa

Effects of different concentrations of bromelain and papain enzymes on shear bond strength of composite resin to deep dentin using an etch-and-rinse adhesive system.

9. Dent Med Probl. 2024 Jan-Feb;61(1):85-91. doi: 10.17219/dmp/133404. Effects of different concentrations of bromelain and papain enzymes on shear bond strength of composite resin to deep dentin using an etch-and-rinse adhesive system. Sharafeddin F(1), Jowkar Z(2), Safari M(1). Author informa

Volumetric analysis after caries excavation with caries detecting dyes and chemomechanical caries removal agents using 3D scanner-a randomised clinical trial.

10. BMC Oral Health. 2024 Feb 1;24(1):164. doi: 10.1186/s12903-024-03907-5. Volumetric analysis after caries excavation with caries detecting dyes and chemomechanical caries removal agents using 3D scanner-a randomised clinical trial. Bastia R(1), Govind S(1), Assiry AA(2), Alessa NA(3), Kader M

9-aminominocycline potentiates the efficacy of EIDD-1931 and PF-332 by targeting the papain like protease enzyme of SARS-CoV-2.

11. Sci Rep. 2025 Feb 15;15(1):5671. doi: 10.1038/s41598-025-89717-3. 9-aminominocycline potentiates the efficacy of EIDD-1931 and PF-332 by targeting the papain like protease enzyme of SARS-CoV-2. Pandey K(#)(1), Lewis DSM(#)(2), Heo K(2), Acharya A(1), Fields T(2), Gowda K(2)(3), Dean G(2), Ra

Integrated Exploration of Pyranocoumarin Derivatives as Synergistic Inhibitors of Dual-target for Mpro and PLpro Proteins of SARS-CoV- 2 through Molecular Docking, ADMET Analysis, and Molecular Dynamics Simulation.

12. Curr Med Chem. 2025;32(26):5530-5543. doi: 10.2174/0109298673331781240829094334. Integrated Exploration of Pyranocoumarin Derivatives as Synergistic Inhibitors of Dual-target for Mpro and PLpro Proteins of SARS-CoV- 2 through Molecular Docking, ADMET Analysis, and Molecular Dynamics Simulatio

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease.

13. Biochem J. 2021 Jul 16;478(13):2517-2531. doi: 10.1042/BCJ20210244. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease. Lim CT(#)(1), Tan KW(#)(1), Wu M(2), Ulferts R(3), Armstrong LA(4), Ozono E(1), Drury LS(1), Milligan JC(1),

Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture.

14. Cell Rep. 2021 May 18;35(7):109133. doi: 10.1016/j.celrep.2021.109133. Epub 2021 Apr 27. Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture. Bafna K(1), White K(2), Harish B(3), Rosales R(2), Ramelot TA

Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21.

15. Int J Biol Macromol. 2021 Apr 15;176:490-497. doi: 10.1016/j.ijbiomac.2021.02.072. Epub 2021 Feb 11. Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21. Lin HC(1), Kuan Y(2), Chu HF(3), Cheng SC(4), Pan HC(4), Chen WY(2), Sun CY(5), Lin TH(6). A

The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery.

30. Nat Commun. 2021 Jan 20;12(1):488. doi: 10.1038/s41467-020-20718-8. The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery. Fu Z(#)(1)(2), Huang B(#)(1)(2), Tang J(#)(1)(2), Liu S(#)(3), Liu M(1)(2), Ye Y(1)(2), Liu Z(1)(2), Xiong Y(1)(2), Zhu W

Antibacterial activity of papain and bromelain on Alicyclobacillus spp.

45. Int J Food Microbiol. 2016 Jan 4;216:121-6. doi: 10.1016/j.ijfoodmicro.2015.10.007. Epub 2015 Oct 8. Antibacterial activity of papain and bromelain on Alicyclobacillus spp. dos Anjos MM(1), da Silva AA(1), de Pascoli IC(1), Mikcha JM(2), Machinski M Jr(3), Peralta RM(4), de Abreu Filho BA(5)

Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus.

5. Antiviral Res. 2015 Mar;115:9-16. doi: 10.1016/j.antiviral.2014.12.011. Epub 2014 Dec 24. Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Cheng KW(1), Cheng SC(2), Chen WY(3), Lin MH(1), Chuang SJ(1), C

A Comprehensive Review of Potential Warfarin-Fruit Interactions.

47. J Pharm Pract. 2015 Dec;28(6):561-71. doi: 10.1177/0897190014544823. A Comprehensive Review of Potential Warfarin-Fruit Interactions. Norwood DA, Parke CK, Rappa LR. PURPOSE: The aim of this review is to discuss possible interactions that may occur between warfarin and fruit products. METHOD

The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon.

15. Antimicrob Agents Chemother. 2014 Aug;58(8):4675-81. doi: 10.1128/AAC.02546-13. Epub 2014 Jun 2. The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon. Rocha-Pereira J(1), Nascimento MS(2), Ma Q(3), Hilgenfe

Anticoronavirus activity of rhizome of Dryopteris crassirhizoma via multistage targeting of virus entry and viral proteases, Mpro and PLpro.

1. J Ethnopharmacol. 2024 Oct 28;333:118490. doi: 10.1016/j.jep.2024.118490. Epub 2024 Jun 25. Anticoronavirus activity of rhizome of Dryopteris crassirhizoma via multistage targeting of virus entry and viral proteases, Mpro and PLpro. Habib M(1), Jin YH(2), Kim Y(3), Min JS(4), Ha IJ(5), Lee SM

Update on occupational contact urticaria: a systematic narrative review.

10. Curr Opin Allergy Clin Immunol. 2026 Apr 1;26(2):84-94. doi: 10.1097/ACI.0000000000001138. Epub 2025 Dec 11. Update on occupational contact urticaria: a systematic narrative review. Bizjak-Suran M(1)(2)(3), Jørgensen IL(4), Alfonso JH(5)(6). Author information: (1)Division of Allergy, Univer

Cathepsin K (CTSK) in Inflammatory and Immune-Mediated Diseases.

9. Immunol Invest. 2026 Jan;55(1):120-142. doi: 10.1080/08820139.2025.2569768. Epub 2025 Oct 9. Cathepsin K (CTSK) in Inflammatory and Immune-Mediated Diseases. Lin S(1), Wang T(1), Zuo C(1). Author information: (1)Department of Nuclear Medicine, The First Affiliated Hospital of Naval Medical U

Interventions for the symptoms and signs resulting from jellyfish stings.

48. Cochrane Database Syst Rev. 2023 Jun 5;6(6):CD009688. doi: 10.1002/14651858.CD009688.pub3. Interventions for the symptoms and signs resulting from jellyfish stings. McGee RG(1)(2), Webster AC(3), Lewis SR(4), Welsford M(5). Author information: (1)The University of Newcastle Central Coast Cli

A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease.

30. Neurotox Res. 2022 Oct;40(5):1553-1569. doi: 10.1007/s12640-022-00542-2. Epub 2022 Aug 2. A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease. Rieder AS(1), Deniz BF(1), Netto CA(1), Wyse ATS(2). Author information: (1)Laboratory of Neuroprotecti

Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review.

19. Sci Rep. 2022 Jul 29;12(1):13028. doi: 10.1038/s41598-022-17371-0. Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review. H S Delgado A(1)(2), Belmar Da Costa M(3), Polido MC(3), Mano Azul A(3), Sauro S(4).

Worldwide research trends on the use of chemical-mechanical caries removal products over the years: a critical review.

48. Eur Arch Paediatr Dent. 2022 Dec;23(6):869-883. doi: 10.1007/s40368-022-00726-6. Epub 2022 Jul 13. Worldwide research trends on the use of chemical-mechanical caries removal products over the years: a critical review. Souza TF(1), Martins ML(1), Magno MB(1), Vicente-Gomila JM(2), Fonseca-Gon

Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis.

16. Acta Pharm. 2021 Dec 30;72(2):199-224. doi: 10.2478/acph-2022-0021. Print 2022 Jun 1. Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis. Ebenezer O(1), Bodede O(2), Awolade P(3), Jordaan MA(1), Ogunsakin RE(4),

Proteolytic Enzyme Therapy in Complementary Oncology: A Systematic Review.

8. Anticancer Res. 2021 Jul;41(7):3213-3232. doi: 10.21873/anticanres.15108. Epub 2021 Jul 5. Proteolytic Enzyme Therapy in Complementary Oncology: A Systematic Review. Gremmler L(1), Kutschan S(2), Dörfler J(2), Büntzel J(3), Büntzel J(4), Hübner J(2). Author information: (1)Department for Hem

Famotidine Repurposing for Novel Corona Virus Disease of 2019: A Systematic Review.

47. Drug Res (Stuttg). 2021 Jul;71(6):295-301. doi: 10.1055/a-1397-6763. Epub 2021 Mar 23. Famotidine Repurposing for Novel Corona Virus Disease of 2019: A Systematic Review. Chenchula S(1), Ray A(1), Sadasivam B(1). Author information: (1)Department of Pharmacology, All India Institute of Medi