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Efficacy and Safety of Standardized Ethanol Extract of Purple Perilla (Perilla frutescens Britton var. acuta Kudo) Leaves in Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

1. Nutrients. 2026 Mar 18;18(6):960. doi: 10.3390/nu18060960. Efficacy and Safety of Standardized Ethanol Extract of Purple Perilla (Perilla frutescens Britton var. acuta Kudo) Leaves in Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Baek HI(1), Joo JC(2), K

Immunomodulatory effects of supercritical CO(2) extracted oils from Portulaca oleracea and Perilla frutescens (PPCE) in healthy individuals: a randomized double-blind clinical trial.

2. Food Funct. 2025 Mar 3;16(5):1708-1719. doi: 10.1039/d4fo03361b. Immunomodulatory effects of supercritical CO(2) extracted oils from Portulaca oleracea and Perilla frutescens (PPCE) in healthy individuals: a randomized double-blind clinical trial. Jung SJ(1)(2)(3), Baek HI(4), Park EO(1)(2),

Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.

3. Phytother Res. 2023 Jun;37(6):2230-2241. doi: 10.1002/ptr.7728. Epub 2023 Jan 13. Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial. Matsuzaki K(1), Hossain S(1)(2), Wakatsuki H(1), Ta

Perilla frutescens seed oil combined with Anredera cordifolia leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: a possible supplement for brain health.

4. Food Funct. 2022 Jul 4;13(13):7226-7239. doi: 10.1039/d2fo00723a. Perilla frutescens seed oil combined with Anredera cordifolia leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: a possible supplement

Perilla Fruit Oil-Fortified Soybean Milk Intake Alters Levels of Serum Triglycerides and Antioxidant Status, and Influences Phagocytotic Activity among Healthy Subjects: A Randomized Placebo-Controlled Trial.

5. Nutrients. 2022 Apr 21;14(9):1721. doi: 10.3390/nu14091721. Perilla Fruit Oil-Fortified Soybean Milk Intake Alters Levels of Serum Triglycerides and Antioxidant Status, and Influences Phagocytotic Activity among Healthy Subjects: A Randomized Placebo-Controlled Trial. Koonyosying P(1), Kusiri

Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supplement for brain health in the elderly.

6. Food Funct. 2022 Mar 7;13(5):2768-2781. doi: 10.1039/d1fo03508h. Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supplement for brain health in the elderly. Hashimoto M(1), Matsuzaki K(1), Maruya

Components, isolated from perilla leaves, synergistically alleviate the inflammation of acute lung injury via Syk/β2-integrin pathway.

7. Fitoterapia. 2025 Jul;184:106655. doi: 10.1016/j.fitote.2025.106655. Epub 2025 Jun 2. Components, isolated from perilla leaves, synergistically alleviate the inflammation of acute lung injury via Syk/β2-integrin pathway. Li X(1), Zheng R(2), Pan W(3), Fang N(1), Yin X(1), Yang L(1), Ma X(1),

Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

8. Oncotarget. 2015 Nov 17;6(36):39292-306. doi: 10.18632/oncotarget.5751. Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cho J(1), Tremmel L(1), Rho O(1), Camelio AM(2), Siegel D(3), Slaga TJ(4),

Interaction between oseltamivir and herbal medicines used for treating avian influenza.

9. Hong Kong Med J. 2012 Dec;18 Suppl 6:34-6. Interaction between oseltamivir and herbal medicines used for treating avian influenza. Yang MS(1), Law FC, Wong RN, Mak NK, Wei XY. Author information: (1)Department of Biology, Hong Kong Baptist University, Hong Kong SAR, China. msyang@hkbu.edu.hk

Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial.

10. Front Pharmacol. 2023 Mar 14;14:1114410. doi: 10.3389/fphar.2023.1114410. eCollection 2023. Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial. Kim N(1), Kim SY(2), Kim SW(1), Lee JM(1), Kim SK(3), Park MH(3), Kim KH(3),

Antioxidant activities of Perilla frutescens against low-density lipoprotein oxidation in vitro and in human subjects.

11. J Oleo Sci. 2012;61(3):113-20. doi: 10.5650/jos.61.113. Antioxidant activities of Perilla frutescens against low-density lipoprotein oxidation in vitro and in human subjects. Saita E(1), Kishimoto Y, Tani M, Iizuka M, Toyozaki M, Sugihara N, Kondo K. Author information: (1)Institute of Envir

Axillary Hyperpigmentation Treatment: A Systematic Review of the Literature.

12. J Cosmet Dermatol. 2025 Aug;24(8):e70418. doi: 10.1111/jocd.70418. Axillary Hyperpigmentation Treatment: A Systematic Review of the Literature. Vahabi SM(1), Sajjadi S(1), Kalantari Y(1)(2), Pourgholi E(1), Heidari S(1), Etesami I(1). Author information: (1)Department of Dermatology, Razi Ho

The Antiviral Potential of Perilla frutescens: Advances and Perspectives.

13. Molecules. 2024 Jul 15;29(14):3328. doi: 10.3390/molecules29143328. The Antiviral Potential of Perilla frutescens: Advances and Perspectives. Chen J(1), Zhao Y(1), Cheng J(1), Wang H(1), Pan S(2), Liu Y(1). Author information: (1)Department of Bioinformatics and Intelligent Diagnosis, School

Health supplements for allergic rhinitis: A mixed-methods systematic review.

14. Complement Ther Med. 2020 Jun;51:102425. doi: 10.1016/j.ctim.2020.102425. Epub 2020 May 17. Health supplements for allergic rhinitis: A mixed-methods systematic review. Pellow J(1), Nolte A(2), Temane A(2), Solomon EM(3). Author information: (1)Department of Complementary Medicine, Universit

Herbal medicines for the treatment of allergic rhinitis: a systematic review.

15. Ann Allergy Asthma Immunol. 2007 Dec;99(6):483-95. doi: 10.1016/S1081-1206(10)60375-4. Herbal medicines for the treatment of allergic rhinitis: a systematic review. Guo R(1), Pittler MH, Ernst E. Author information: (1)Department of Complementary Medicine, Peninsula Medical School, Universit