PQQ

Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress-A Pilot Study.

1. Nutrients. 2024 Sep 3;16(17):2965. doi: 10.3390/nu16172965. Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress-A Pilot Study. Bosco G(1), Vezzoli A(1)(2), Brizzolari A(1), Paganini M(1), Giacon TA(1), Savini

The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial.

2. J Nutr Health Aging. 2024 Aug;28(8):100287. doi: 10.1016/j.jnha.2024.100287. Epub 2024 Jun 21. The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a rando

Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults.

3. Food Funct. 2023 Mar 6;14(5):2496-2501. doi: 10.1039/d2fo01515c. Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults. Tamakoshi M(1), Suzuki T(1), Nishihara E(2), Nakamura S(2), Ikemoto K(3). Author information: (1)Department of Life Science, Mitsub

Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.

4. J Am Nutr Assoc. 2022 Nov-Dec;41(8):796-809. doi: 10.1080/07315724.2021.1962770. Epub 2021 Aug 20. Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. Shiojima Y(1), Takaha

Effects of Pyrroloquinoline Quinone (PQQ) Supplementation on Aerobic Exercise Performance and Indices of Mitochondrial Biogenesis in Untrained Men.

5. J Am Coll Nutr. 2020 Aug;39(6):547-556. doi: 10.1080/07315724.2019.1705203. Epub 2019 Dec 20. Effects of Pyrroloquinoline Quinone (PQQ) Supplementation on Aerobic Exercise Performance and Indices of Mitochondrial Biogenesis in Untrained Men. Hwang PS(1), Machek SB(1), Cardaci TD(1), Wilburn D

Effects of Antioxidant Supplements (BioPQQ™) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex.

6. Adv Exp Med Biol. 2016;923:215-222. doi: 10.1007/978-3-319-38810-6_29. Effects of Antioxidant Supplements (BioPQQ™) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex. Nakano M(1), Murayama Y(2), Hu L(2), Ikemoto K(1), Uetake T(3), Sakatani K(4)(5). Author information: (1)

Dietary supplementation of pyrroloquinoline quinone disodium protects against oxidative stress and liver damage in laying hens fed an oxidized sunflower oil-added diet.

7. Animal. 2016 Jul;10(7):1129-36. doi: 10.1017/S175173111600001X. Epub 2016 Feb 3. Dietary supplementation of pyrroloquinoline quinone disodium protects against oxidative stress and liver damage in laying hens fed an oxidized sunflower oil-added diet. Wang J(1), Zhang HJ(1), Xu L(1), Long C(1),

Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions.

8. Adv Exp Med Biol. 2016;876:319-325. doi: 10.1007/978-1-4939-3023-4_40. Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions. Itoh Y(1), Hine K(1), Miura H(1), Uetake T(2), Nakano M(3), Takemura N(4), Sakatani K(4)(5). Author information

Effects of Pyrroloquinoline Quinone Disodium Salt Intake on the Serum Cholesterol Levels of Healthy Japanese Adults.

9. J Nutr Sci Vitaminol (Tokyo). 2015;61(3):233-40. doi: 10.3177/jnsv.61.233. Effects of Pyrroloquinoline Quinone Disodium Salt Intake on the Serum Cholesterol Levels of Healthy Japanese Adults. Nakano M(1), Kawasaki Y, Suzuki N, Takara T. Author information: (1)Planning and Development Division

Effects of dietary pyrroloquinoline quinone disodium on growth, carcass characteristics, redox status, and mitochondria metabolism in broilers.

10. Poult Sci. 2015 Feb;94(2):215-25. doi: 10.3382/ps/peu050. Epub 2015 Jan 20. Effects of dietary pyrroloquinoline quinone disodium on growth, carcass characteristics, redox status, and mitochondria metabolism in broilers. Wang J(1), Zhang HJ(1), Samuel KG(1), Long C(1), Wu SG(1), Yue HY(1), Sun

Enhancing Stability of Vitamin-Fortified Protein Beverages: Optimization of Stabilizer Type and Concentration and Screening of Natural Antioxidant Combinations.

11. Foods. 2026 Apr 16;15(8):1392. doi: 10.3390/foods15081392. Enhancing Stability of Vitamin-Fortified Protein Beverages: Optimization of Stabilizer Type and Concentration and Screening of Natural Antioxidant Combinations. Li J(1)(2), Ru S(1)(2), Zhu L(1)(2), Lu Y(3), Wang J(1)(2), Zhang Y(3),

An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT.

12. Redox Biol. 2026 Apr 24;93:104191. doi: 10.1016/j.redox.2026.104191. Online ahead of print. An integrated anti-aging framework targeting NAD(+) homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT. Sun Y(1), Han JC(1), Tran K(1), Pham T(2), Zhou Q(3)

Endophytic Biostimulant Pyrroloquinoline Quinone Enhances Banana Growth and Primes Immunity Against Fusarium Wilt.

13. Physiol Plant. 2026 May-Jun;178(3):e70913. doi: 10.1111/ppl.70913. Endophytic Biostimulant Pyrroloquinoline Quinone Enhances Banana Growth and Primes Immunity Against Fusarium Wilt. Hung SW(1)(2)(3), Yu MY(1), Liu CH(1), Huang TC(1), Peng JH(4)(5)(6)(7)(8), Jang NY(1), Kuo CH(2)(4)(5)(9), Ya

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction.

14. Aging Cell. 2026 May;25(5):e70526. doi: 10.1111/acel.70526. Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction. Yu K(1), Wang N(1), Huang X(1), Qiu Y(2), He X(1), Zhu X(1), Zhou X(1), Yu P(1), Wei G(1), Pi Y(1), Ni T(1

Pyrroloquinoline quinone scaffolds: centrality in anticancer drug design.

15. Future Med Chem. 2026 Apr 13:1-9. doi: 10.1080/17568919.2026.2658006. Online ahead of print. Pyrroloquinoline quinone scaffolds: centrality in anticancer drug design. Sen S(1), Karati D(1). Author information: (1)Department of Pharmaceutical Technology, School of Pharmacy, Techno India Univ

Microgravity effects on secondary metabolism of plant-affecting bacteria.

44. Microbiol Spectr. 2026 Mar 30:e0223925. doi: 10.1128/spectrum.02239-25. Online ahead of print. Microgravity effects on secondary metabolism of plant-affecting bacteria. Sharma G(1), Ahmed MMA(2), Ali T(2), Boudreau PD(2), Curtis PD(1). Author information: (1)Department of Biology, University

Mechanistic study on PQQ improving the quality of aged bovine oocytes and early embryonic developmental potential via Nrf2-mediated redox signaling.

6. Cell Signal. 2026 Jul;143:112473. doi: 10.1016/j.cellsig.2026.112473. Epub 2026 Mar 9. Mechanistic study on PQQ improving the quality of aged bovine oocytes and early embryonic developmental potential via Nrf2-mediated redox signaling. You BY(1), Wu HK(1), Zhou XY(1), Zhao JH(1), Cheng BW(1),

Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation.

32. Phytomedicine. 2026 Apr;153:157996. doi: 10.1016/j.phymed.2026.157996. Epub 2026 Feb 22. Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation. Xue Q(1),

Pyrroloquinoline Quinone Protects Against Light-Induced Retinal Damage in Association with the Suppression of c-Fos Signalling.

5. Int J Mol Sci. 2026 Feb 17;27(4):1929. doi: 10.3390/ijms27041929. Pyrroloquinoline Quinone Protects Against Light-Induced Retinal Damage in Association with the Suppression of c-Fos Signalling. Ozawa H(1), Sugano E(1)(2), Tabata K(1), Kakizaki T(1), Sato A(1), Takai Y(3), Sone K(3), Shidomi M

Pyrroloquinoline Quinone Alleviates Tris(1,3-Dichloro-2-Propyl) Phosphate-Induced Damage During Mouse Oocyte Maturation.

2. Animals (Basel). 2026 Feb 21;16(4):673. doi: 10.3390/ani16040673. Pyrroloquinoline Quinone Alleviates Tris(1,3-Dichloro-2-Propyl) Phosphate-Induced Damage During Mouse Oocyte Maturation. Sun L(1)(2), Cao Z(1)(3), Xiao L(1), Bai J(1), Liu K(1), Qin Y(1), Liu Y(1), Xu X(1). Author information:

Characterization of a membrane-bound PQQ-dependent D-lactate dehydrogenase in Gluconobacter japonicus.

1. Appl Microbiol Biotechnol. 2026 Apr 20. doi: 10.1007/s00253-026-13818-w. Online ahead of print. Characterization of a membrane-bound PQQ-dependent D-lactate dehydrogenase in Gluconobacter japonicus. Kataoka N(1)(2), Takeuchi S(3), Maeno S(4)(5), Matsutani M(6), Matsushita K(5)(7), Yakushi T(

Pyrroloquinoline quinone enhances in vitro maturation of porcine oocytes and supports ensuing embryonic development.

48. Theriogenology. 2026 Apr 15;261:117935. doi: 10.1016/j.theriogenology.2026.117935. Online ahead of print. Pyrroloquinoline quinone enhances in vitro maturation of porcine oocytes and supports ensuing embryonic development. Zhai D(1), Diao Y(2), Wu Y(1), Dong X(3), Ai P(4), Cai Y(1), Yuan Y(4

Thirty days of supplementation with PQQ reprograms immunometabolic networks in Western diet-fed female baboons.

20. bioRxiv [Preprint]. 2026 Feb 13:2026.02.12.705540. doi: 10.64898/2026.02.12.705540. Thirty days of supplementation with PQQ reprograms immunometabolic networks in Western diet-fed female baboons. Dockins SG, Hyatt KE, Reuter DN, Stevens TL, Tresler AB, Papin JF, Myers DA, Jonscher KR. West

Nutritional activation of the Nrf2-Pth1r axis by pyrroloquinoline quinone enhances peak bone mass and potentiates teriparatide in osteoporosis.

35. Free Radic Biol Med. 2026 Apr;247:393-406. doi: 10.1016/j.freeradbiomed.2026.02.026. Epub 2026 Feb 11. Nutritional activation of the Nrf2-Pth1r axis by pyrroloquinoline quinone enhances peak bone mass and potentiates teriparatide in osteoporosis. Xue Q(1), Gu Y(2), Li J(1), Qin R(2), Li M(3)

The effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study.

9. Sci Rep. 2026 Feb 6;16(1):5408. doi: 10.1038/s41598-025-34191-0. The effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study. Zhao C(1), Wu B(1), Sui H(1), Ku

No effect of pyrroloquinoline quinone on mouse body weight and energy metabolism with the concomitant increase in mitochondrial biogenesis and antioxidant ability.

4. Metabol Open. 2025 Dec 11;29:100433. doi: 10.1016/j.metop.2025.100433. eCollection 2026 Mar. No effect of pyrroloquinoline quinone on mouse body weight and energy metabolism with the concomitant increase in mitochondrial biogenesis and antioxidant ability. Zhang L(1), Xu Y(2), Zhao Y(1), Zha

Pyrroloquinoline quinone promotes porcine oocyte in vitro maturation and subsequent embryo development by enhancing lipid metabolism and improving mitochondrial function.

11. Anim Biosci. 2025 Aug;38(8):1644-1656. doi: 10.5713/ab.24.0847. Epub 2025 Apr 11. Pyrroloquinoline quinone promotes porcine oocyte in vitro maturation and subsequent embryo development by enhancing lipid metabolism and improving mitochondrial function. Zhang Z(1), Gao Z(1), Jia Z(1). Autho

Pyrroloquinoline Quinone Reprograms the Single-Cell Landscape of Immune Aging in Hematopoietic Immune System.

48. Aging Cell. 2025 Jul;24(7):e70050. doi: 10.1111/acel.70050. Epub 2025 Apr 7. Pyrroloquinoline Quinone Reprograms the Single-Cell Landscape of Immune Aging in Hematopoietic Immune System. Liu X(1)(2), Zhang C(1), Lv J(2), Liu Y(2), Gu C(2), Gao Y(2), Ding W(3), Chen H(1), Xu N(1)(4), Yin H(1)

Insight into the unique analytical capabilities of the redox cycling of quinones: A comprehensive review.

39. Talanta. 2026 Aug 1;305:129573. doi: 10.1016/j.talanta.2026.129573. Epub 2026 Feb 23. Insight into the unique analytical capabilities of the redox cycling of quinones: A comprehensive review. Abdel-Hakim A(1), Ali MAM(2), Kishikawa N(3), El-Maghrabey M(4). Author information: (1)Department

Pyrroloquinoline quinone ameliorates inflammatory responses by modulating macrophage polarization in murine models of SLE and lupus-associated diffuse alveolar hemorrhage.

31. Int Immunopharmacol. 2026 Mar 1;172:116219. doi: 10.1016/j.intimp.2026.116219. Epub 2026 Jan 20. Pyrroloquinoline quinone ameliorates inflammatory responses by modulating macrophage polarization in murine models of SLE and lupus-associated diffuse alveolar hemorrhage. Long H(1), Zhou Y(1),