차전자피 (프리바이오틱스)
Psyllium Husk (Prebiotic)
📚 관련 논문 (21편)
1. Gut Microbes. 2023 Jan-Dec;15(1):2197837. doi: 10.1080/19490976.2023.2197837. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Lai H(1), Li Y(1), He Y(1), Chen F(1), Mi B(1), Li J(1), Xie J(1), M
1. Front Surg. 2025 Dec 9;12:1686486. doi: 10.3389/fsurg.2025.1686486. eCollection 2025. Effect of psyllium husk on low anterior resection syndrome after rectal cancer surgery-a pilot prospective cohort study. Holte SS(1)(2), Avaliani N(3)(4), Hoff G(3), Kazaryan AM(5)(6)(7), Jaioun K(3), Lauzikas G(1), Schultz JK(2)(8). Author information: (1)Department of Gastrointestinal Surgery, Telemark Hospital Trust, Skien, Norway. (2)Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. (3)Department of Research and Innovation, Telemark Hospital Trust, Skien, Norway. (4)Faculty of Medicine, European University, Tbilisi, Georgia. (5)Department of Gastrointestinal Surgery, Østfold Hospital Trust, Grålum, Norway. (6)Department of Surgery N1, Yerevan State Medical University After M. Heratsi, Yerevan, Armenia. (7)Department of Surgery N2, I.M.Sechenov First Moscow State Medical University, Moscow, Russia. (8)Department of Gastrointestinal Surgery, Akershus University Hospital, Lørenskog, Norway. INTRODUCTION: Low anterior resection syndrome (LARS) is a frequent, undesired consequence of rectal cancer surgery. Psyllium husk has been suggested as a nutritional supplement in the management of LARS, but without trial-based evidence of its effect. In preparation of a randomized clinical trial, this pilot study aimed to estimate the effect of Psyllium husk in patients with LARS, determining the treatment duration required to observe the effect and assess patient compliance. METHODS: This single arm phase II study included patients with LARS score >20 ten months or more after rectal resection. Patients who consented to participate were given 3.66 g Psyllium husk fiber twice daily for 56 days. The primary endpoint was severity of bowel dysfunction using the LARS score. The secondary endpoint was quality of life (QoL) using EQ-VAS score in the EQ-5D-5L questionnaire. A reduction of 7 points in LARS score was considered clinically relevant. Questionnaires and scores were collected on paper day 0 (baseline), day 28 and day 56. RESULTS: 22 patients were assigned to the intervention and included in the analysis. The average age was 65.3 (SD 10.4), the average LARS score at baseline was 35,7 (SD 3.5), four patients had received radiotherapy. The proportion of patients with a LARS score reduction of 7 points or more compared to baseline was 50.0% at day 28 (11/22) and 50.0% at day 56 (10/20). The mean reduction in LARS scores from baseline to 8 weeks of treatment was 7.7 points. At day 28, the proportion of patients with a QoL score (EQ-VAS score) increase of 10 points or more was 36.4% (8/22), increasing to 60.0% (12/20) by day 56. Two patients dropped out after 4 weeks of treatment, one due to taste and consistency of the supplement and one due to inconsistently beneficial effect. CONCLUSIONS: Psyllium husk appears to clinically significantly improve both bowel dysfunction and QoL in rectal cancer patients suffering from LARS. This study highlights the need for further systematic research, and provides a strong basis for a well-designed RCT. © 2025 Holte, Avaliani, Hoff, Kazaryan, Jaioun, Lauzikas and Schultz. DOI: 10.3389/fsurg.2025.1686486 PMCID: PMC12722911 PMID: 41446326 Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
2. Int J Mol Sci. 2019 Jan 20;20(2):433. doi: 10.3390/ijms20020433. The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls. Jalanka J(1)(2), Major G(3), Murray K(4), Singh G(5), Nowak A(6), Kurtz C(7), Silos-Santiago I(8), Johnston JM(9), de Vos WM(10), Spiller R(11). Author information: (1)Immunobiology Research Program and Department of Bacteriology and Immunology, Faculty of Medicine, University of Helsinki, 00014 HY Helsinki, Finland. Jonna.Jalanka@helsinki.fi. (2)Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust, the University of Nottingham, Notts NG7 2UH, UK. Jonna.Jalanka@helsinki.fi. (3)Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust, the University of Nottingham, Notts NG7 2UH, UK. giles.major1@nottingham.ac.uk. (4)Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust, the University of Nottingham, Notts NG7 2UH, UK. Kathryn.Murray@nottingham.ac.uk. (5)Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust, the University of Nottingham, Notts NG7 2UH, UK. Gulzar.Singh@nottingham.ac.uk. (6)Nottingham University Hospitals NHS Trust, the University of Nottingham, Nottinghamshire NG5 1PB, UK. adam.nowak@nhs.net. (7)Synlogic therapeutics, Cambridge, MA 02142, USA. carolinebkurtz@gmail.com. (8)Decibel Therapeutics Inc., Boston, MA 02215, USA. asilos@decibeltx.com. (9)Neurogastrx, Inc., Woburn, MA 01801, USA, formerly at Ironwood Pharmaceuticals, Cambridge, MA 02142, USA. jjohnston@neurogastrx.com. (10)Laboratory of Microbiology, Wageningen University, 6708WE Wageningen, The Netherlands. willem.devos@wur.nl. (11)Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust, the University of Nottingham, Notts NG7 2UH, UK. Robin.Spiller@Nottingham.ac.uk. Psyllium is a widely used treatment for constipation. It traps water in the intestine increasing stool water, easing defaecation and altering the colonic environment. We aimed to assess the impact of psyllium on faecal microbiota, whose key role in gut physiology is being increasingly recognised. We performed two randomised, placebo-controlled, double-blinded trials comparing 7 days of psyllium with a placebo (maltodextrin) in 8 healthy volunteers and 16 constipated patients respectively. We measured the patients' gastrointestnal (GI) transit, faecal water content, short-chain fatty acid (SCFA) and the stool microbiota composition. While psyllium supplement had a small but significant effect on the microbial composition of healthy adults (increasing Veillonella and decreasing Subdoligranulum), in constipated subjects there were greater effects on the microbial composition (increased Lachnospira, Faecalibacterium, Phascolarctobacterium, Veillonella and Sutterella and decreased uncultured Coriobacteria and Christensenella) and alterations in the levels of acetate and propionate. We found several taxa to be associated with altered GI transit, SCFAs and faecal water content in these patients. Significant increases in three genera known to produce butyrate, Lachnospira, Roseburia and Faecalibacterium, correlated with increased faecal water. In summary, psyllium supplementation increased stool water and this was associated with significant changes in microbiota, most marked in constipated patients. DOI: 10.3390/ijms20020433 PMCID: PMC6358997 PMID: 30669509 [Indexed for MEDLINE] Conflict of interest statement: GM: speakers fees from Allergan and Vertex. RS: research funding from research funding from LeSaffre, Norgine, Ironwood and Zespri Group Ltd. He has also acted on advisory boards for Napo Pharmaceuticals, Commonwealth International, Yuhan Corporation, Ibsen, Danone and Almirall, and received speakers’ fees from Menarini and Alfawasserman. IS-S, CK and JF: employees of Ironwood Pharmaceuticals Inc. at the time of the study. Other authors have nothing relevant to declare. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
3. J Feline Med Surg. 2011 Jun;13(6):405-9. doi: 10.1016/j.jfms.2010.12.015. Epub 2011 May 14. Azodyl, a synbiotic, fails to alter azotemia in cats with chronic kidney disease when sprinkled onto food. Rishniw M(1), Wynn SG. Author information: (1)Veterinary Information Network, 777 West Covell Blvd, Davis, CA 95616, USA. mark@vin.com The effect of probiotic therapy in chronic kidney disease (CKD) in cats is poorly defined, but gaining in popularity. However, cat owners often prefer to administer probiotics by combining them with food, rather than administering capsules intact, as is prescribed by the manufacturer. The efficacy of such non-recommended administration is unknown. In this double-blinded, controlled clinical trial, 10 cats with naturally-occurring CKD were randomized to receive either a probiotic-prebiotic combination (synbiotic) or psyllium husk (prebiotic only) for 2 months. Medications were sprinkled and mixed into food or given as a slurry. Blood urea nitrogen (BUN) and creatinine were measured twice prior to administration of medication, and then monthly for 2 months during the medication administration. Owners and clinicians were masked as to treatment. The maximal percentage change in BUN and creatinine was calculated for each cat. No differences in percentage change were detected between groups (P=0.8 for both BUN and creatinine). The synbiotic supplement used in this study, when applied to food or administered as a slurry fails to reduce azotemia in cats with CKD. Therefore, owners should not administer this synbiotic in this manner. Copyright © 2011 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved. DOI: 10.1016/j.jfms.2010.12.015 PMCID: PMC10832703 PMID: 21571563 [Indexed for MEDLINE]
4. Arch Intern Med. 2005 May 23;165(10):1161-6. doi: 10.1001/archinte.165.10.1161. Effect of combining psyllium fiber with simvastatin in lowering cholesterol. Moreyra AE(1), Wilson AC, Koraym A. Author information: (1)Division of Cardiology Lipid Disorder Center, Department of Medicine, Robert Wood Johnson Medical School, University of Medicine & Dentistry of New Jersey, New Brunswick, USA. abel.moreyra@rwjuh.edu BACKGROUND: Soluble fiber supplements are recommended to reduce levels of low-density lipoprotein cholesterol (LDL-C). We evaluated the LDL-C-lowering effect of psyllium husk added to low-dose simvastatin therapy. METHODS: In a 12-week blinded placebo-controlled study, patients were randomized to receive 20 mg of simvastatin plus placebo, 10 mg of simvastatin plus placebo, or 10 mg of simvastatin plus 15 g of psyllium (Metamucil) daily. Levels of total cholesterol, LDL-C, high-density lipoprotein cholesterol, triglycerides, and apolipoprotein B were determined after 4 and 8 weeks of treatment. RESULTS: The study group comprised 68 patients. All treatments were well tolerated, and after 8 weeks the mean LDL-C levels in the group receiving 10 mg of simvastatin plus placebo fell by 55 mg/dL (1.42 mmol/L) from baseline, compared with 63 mg/dL (1.63 mmol/L) in the group receiving 10 mg of simvastatin plus psyllium (P = .03). The mean lowering of LDL-C in the group receiving 20 mg of simvastatin plus placebo was the same as that in the group receiving 10 mg of simvastatin plus psyllium. Similar results were seen for apolipoprotein B and total cholesterol. No significant changes from baseline triglyceride or high-density lipoprotein cholesterol levels occurred. CONCLUSIONS: Dietary psyllium supplementation in patients taking 10 mg of simvastatin is as effective in lowering cholesterol as 20 mg of simvastatin alone. Psyllium soluble fiber should be considered as a safe and well-tolerated dietary supplement option to enhance LDL-C and apolipoprotein B lowering. DOI: 10.1001/archinte.165.10.1161 PMID: 15911730 [Indexed for MEDLINE]
5. Dis Colon Rectum. 2000 Jan;43(1):66-9. doi: 10.1007/BF02237246. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial. Ho YH(1), Tan M, Seow-Choen F. Author information: (1)Department of Colorectal Surgery, Singapore General Hospital, Singapore. Comment in Dis Colon Rectum. 2000 Nov;43(11):1638-9. doi: 10.1007/BF02236759. PURPOSE: The aim of this study was to assess the role of micronized purified flavonidic fraction in the management of bleeding nonprolapsed hemorrhoids. METHODS: Patients were randomly assigned to receive ispaghula husk alone, rubber band ligation plus ispaghula husk, or micronized purified flavonidic fraction plus ispaghula husk. Other colorectal diseases were excluded by colonoscopy. Blinded observers noted the time for bleeding to stop completely, recurrences, and treatment complications. RESULTS: A total of 162 patients were randomly assigned with no significant differences in the age and gender distributions among the groups. Hemorrhoidal bleeding was relieved most expediently in the micronized purified flavonidic fraction plus ispaghula husk group (ispaghula husk alone n = 66, mean (standard error of the mean) 10.6 (2.3) days; rubber band ligation plus ispaghula husk n = 57, 5.6 (1.1) days; micronized purified flavonidic fraction plus ispaghula husk n = 39, 3.9 (1.2) days; P = 0.03). However, there were no significant differences in the recurrences at six months of follow-up (ispaghula husk alone n = 8 (12 percent); rubber band ligation plus ispaghula husk n = 12 (21 percent); micronized purified flavonidic fraction plus ispaghula husk n = 2 (5.1 percent); P = 0.075). No complications or side-effects were noted. CONCLUSIONS: micronized purified flavonidic fraction used with fiber supplements rapidly and safely relieved bleeding from nonprolapsed hemorrhoids. DOI: 10.1007/BF02237246 PMID: 10813126 [Indexed for MEDLINE]
6. Am J Clin Nutr. 1994 Feb;59(2):395-400. doi: 10.1093/ajcn/59.2.395. Effect of Plantago ovata (psyllium) husk and seeds on sterol metabolism: studies in normal and ileostomy subjects. Gelissen IC(1), Brodie B, Eastwood MA. Author information: (1)Gastro-Intestinal Laboratory, Western General Hospital, Edinburg, UK. The diet of six normal and five ileostomy subjects was supplemented with 10 g/d Plantago ovata psyllium husk for 3 wk while six normal and four ileostomy subjects received 10 g/d psyllium seed. Fecal and ileostomy output, sterol excretion, serum cholesterol, and triglycerides were measured before and after supplementation. The husk had no effect on cholesterol or triglyceride concentrations in either normal or ileostomy subjects. Total and high-density-lipoprotein-cholesterol concentrations were reduced on average by 6.4% and 9.3%, respectively, in the normal group after seed supplementation. No effect on fecal bile acid excretion in the normal subjects was found after both regimes. Ileostomy bile acids were increased (on average 25%) after seed supplementation, whereas no effect on cholesterol concentrations was found. These results suggest that psyllium seed might be more effective than the husk in reducing serum cholesterol, that this cholesterol-lowering effect is not mediated by increased fecal bile acid losses, and increased ileal losses of bile acids might be compensated for by enhanced reabsorption in the colon. DOI: 10.1093/ajcn/59.2.395 PMID: 8310991 [Indexed for MEDLINE]
7. J Health Popul Nutr. 2025 Oct 22;44(1):372. doi: 10.1186/s41043-025-01103-x. The effect of psyllium consumption on anthropometric indices: a systematic review and dose-response meta-analysis of randomized controlled trials. Gholami Z(1)(2), Paknahad Z(3). Author information: (1)School of Nutrition and Food Science, Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. (2)Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. (3)Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. paknahad@hlth.mui.ac.ir. BACKGROUND: The available evidence suggests that psyllium may have a beneficial effect on anthropometric indices. Therefore, this study aims to investigate the impact of psyllium consumption on various anthropometric indices, including Waist-to-Hip Ratio, BMI, Waist Circumference, and body weight. METHODS: We conducted a systematic review and dose-response meta-analysis of randomized controlled trials, searching databases such as Scopus, the Information Sciences Institute Web of Science, and PubMed for relevant articles published between March 15, 2022, and July 22, 2025. RESULTS: The review includes 27 randomized controlled trials that evaluate the effects of psyllium husk on the anthropometric parameters mentioned above in adults. The findings indicate that psyllium significantly increased body weight, with a WMD of 3.57 (95% confidence intervals: 1.43, 5.72; p-value < 0.05). However, there was a non-significant decrease in BMI, with a WMD of -0.06 (95% confidence intervals: -0.68, 0.55; p-value > 0.05), and a non-significant decrease in WHR, with a WMD of -0.10 (95% confidence intervals: -0.34, 0.12; p-value > 0.05). Additionally, there was a non-significant increase in WC, with a WMD of 0.72 (95% confidence intervals: -0.93, 2.37; p-value > 0.05). CONCLUSION: In summary, this study found that psyllium significantly increased body weight. REGISTRATION: The study was approved by the Medical Ethics Committee of Isfahan University of Medical Sciences (IR.MUI. RESEARCH: REC.1402.090, Grant number: 140247). This research was registered in the PROSPERO system (CRD42023422744). © 2025. The Author(s). DOI: 10.1186/s41043-025-01103-x PMCID: PMC12542120 PMID: 41126340 [Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: The study was approved by the Medical Ethics Committee of Isfahan University of Medical Sciences (IR.MUI.RESEARCH.REC.1402.090, Grant number: 140247). This research was registered in the PROSPERO system (CRD42023422744).Zamzam Paknahad and all authors have read and approved the final version of the manuscript had full access to all of the data in this study and takes complete responsibility for the integrity of the data and the accuracy of the data analysis Consent for publication: NA (Not Available or Not Applicable). Competing interests: The authors declare no competing interests. Transparency statement: The primary author, Z.P. confirms the authenticity, accuracy, and transparency of the current study's report. Moreover, no crucial elements of the research have been omitted, and any deviations from the original study design (if applicable, registered) have been clarified. Transparency statement: The primary author, Z.P. confirms the authenticity, accuracy, and transparency of the current study’s report. Moreover, no crucial elements of the research have been omitted, and any deviations from the original study design (if applicable, registered) have been clarified. Clinical trial number: NA (Not Available or Not Applicable). Full uncropped gels and blots image(s): NA (Not Available or Not Applicable) Human ethics and consent to participate: NA (Not Available or Not Applicable)
8. Nutr Res. 2024 Jun;126:123-137. doi: 10.1016/j.nutres.2024.03.013. Epub 2024 Apr 3. Plantago consumption significantly reduces total cholesterol and low-density lipoprotein cholesterol in adults: A systematic review and meta-analysis. Zhu R(1), Lei Y(1), Wang S(1), Zhang J(2), Mengjiao Lv(1), Jiang R(1), Zhou J(1), Li T(3), Guo L(4). Author information: (1)Department of Rehabilitation, School of Nursing, Jilin University, Changchun, Jilin, China, 130021. (2)College of Animal Sciences, Jilin University, Changchun, Jilin, China, 130062. (3)College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China, 130021. (4)Department of Rehabilitation, School of Nursing, Jilin University, Changchun, Jilin, China, 130021. Electronic address: guolr@jlu.edu.cn. Plantago is rich in soluble fiber, known for its beneficial health effects. Given this, we hypothesized that Plantago consumption might positively influence blood lipid in adults. Researchers have conducted numerous randomized controlled trials (RCTs), revealing the impacts of Plantago consumption on various blood lipid parameters. However, findings regarding specific blood lipid parameters have shown variability. This study aimed to comprehensively assess the effect of Plantago consumption on blood lipid parameters. Eligible studies evaluating the effects of Plantago consumption on blood lipid were searched in 5 electronic databases published up to August 2023. Analysis used a random effects model to determine weighted mean difference and 95% confidence intervals. In total, 29 RCTs including 2769 participants were included. Compared with the control group, Plantago consumption significantly reduced total cholesterol (TC) by 0.28 mmol/L and low-density lipoprotein cholesterol (LDL-C) by 0.35 mmol/L, correlating to an estimated 7% decrease in cardiovascular event risk. Conversely, no substantial effects were observed on high-density lipoprotein cholesterol or triglycerides. Subgroup analyses of 29 RCTs revealed that TC concentrations were significantly lowered in studies that included male participants, those who were healthy, or had lipid disorders. Additionally, TC and LDL-C were significantly lower in participants consuming Plantago husk or psyllium, and soluble fiber intake was specifically effective in lowering TC, LDL-C, and triglycerides. In conclusion, Plantago consumption can significantly lower TC and LDL-C concentrations. The findings will provide crucial insights into the potential of Plantago in dietary strategies for blood lipid management. Copyright © 2024 Elsevier Inc. All rights reserved. DOI: 10.1016/j.nutres.2024.03.013 PMID: 38688104 [Indexed for MEDLINE]
9. Clin Nutr ESPEN. 2022 Dec;52:340-352. doi: 10.1016/j.clnesp.2022.09.015. Epub 2022 Sep 20. What is the efficacy of dietary, nutraceutical, and probiotic interventions for the management of gastroesophageal reflux disease symptoms? A systematic literature review and meta-analysis. Martin Z(1), Spry G(2), Hoult J(3), Maimone IR(4), Tang X(5), Crichton M(6), Marshall S(7). Author information: (1)Faculty of Health Sciences and Medicine, Bond University, Robina, Queensland, 4226, Australia; HealthWISE, Ipswich, Queensland, 4305, Australia. Electronic address: zoe.martin@healthwise.org.au. (2)Faculty of Health Sciences and Medicine, Bond University, Robina, Queensland, 4226, Australia; Eat Smart Nutrition, Brisbane, Queensland, 4122, Australia. Electronic address: georgia@eatsmartnutrition.com. (3)Weightloss Solution Australia, Varsity Lakes, Queensland, 4227, Australia. Electronic address: dietitian@wlsa.com.au. (4)Weightloss Solution Australia, Varsity Lakes, Queensland, 4227, Australia. Electronic address: isabella@wlsa.com.au. (5)Bond University Nutrition and Dietetics Group, Faculty of Health Sciences and Medicine, Bond University, Robina, Queensland, 4226, Australia. Electronic address: stang@bond.edu.au. (6)Bond University Nutrition and Dietetics Group, Faculty of Health Sciences and Medicine, Bond University, Robina, Queensland, 4226, Australia; Cancer and Palliative Care Outcomes Centre, Queensland University of Technology, Brisbane, Queensland, Australia. Electronic address: megan.crichton@qut.edu.au. (7)Bond University Nutrition & Dietetics Group, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia; Research Institute for Future Health, Gold Coast, Australia. Electronic address: skye@rifhealth.org. BACKGROUND: Treatments for Gastroesophageal Reflux Disease (GERD) symptoms include pharmaceutical, surgical, dietary, and lifestyle behaviors; however, dietary interventions lack evidence synthesis. RESEARCH QUESTION: What is the effect of dietary, probiotic, and nutraceutical interventions on GERD symptoms, with or without pharmaceutical therapy, in adults with a history of GERD or functional dyspepsia compared to no intervention, placebo, or usual care? METHOD: A systematic review and meta-analysis was performed according to PRISMA. The search strategy was implemented in MEDLINE, CINAHL, CENTRAL, and Embase on the 28th October 2020 and updated to 27th July 2021. Intervention studies were eligible if they evaluated the effect of a dietary, nutraceutical, or probiotic intervention on GERD symptoms in adults with a history of GERD or functional dyspepsia. The internal validity of studies was assessed using the Academy Quality Criteria Checklist; Review Manager software was used to perform meta-analysis; and certainty in the body of evidence was assessed using GRADE. RESULTS: 6,608 study records were retrieved from the search, with 21 studies (n = 24 highly heterogenous intervention groups) included (n = 10 restrictive dietary interventions; n = 3 non-restrictive dietary interventions; n = 8 nutraceutical interventions; and n = 3 probiotic interventions). GERD symptoms were clinically and statistically improved by a test-based elimination diet (n = 1 study), low nickel diet (n = 1 study), probiotic yoghurt (n = 1 study), psyllium husk (n = 1 study), prickly pear and olive leaf extract supplement (n = 1 study), and melatonin, amino acid and b-group vitamin supplement (n = 1 study) according to qualitative synthesis. Ginger-containing supplements could be meta-analyzed, and improved incidence of GERD symptom alleviation (n = 2 studies, OR: 7.50 [95%CI: 3.62-15.54], GRADE: high). No clinically and/or statistically significant effects were found for the remaining n = 16 highly heterogenous interventions. CONCLUSION: Evidence to guide the dietary management of GERD symptoms is limited in scope, quality, and feasibility. Based on the limited evidence available, dietary GERD management should be long-term, individualized, and consider both dietary restrictions and/or additions. PROSPERO ID: CRD42021224082. Copyright © 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. DOI: 10.1016/j.clnesp.2022.09.015 PMID: 36513474 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare no conflicts of interest for this study.
10. Am J Clin Nutr. 2000 Feb;71(2):472-9. doi: 10.1093/ajcn/71.2.472. Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Anderson JW(1), Allgood LD, Lawrence A, Altringer LA, Jerdack GR, Hengehold DA, Morel JG. Author information: (1)Veterans Affairs Medical Center and the University of Kentucky, Lexington, USA. jwandersmd@aol.com Comment in Am J Clin Nutr. 2000 Feb;71(2):401-2. doi: 10.1093/ajcn/71.2.401. Am J Clin Nutr. 2001 Mar;73(3):653-4. doi: 10.1093/ajcn/73.3.653. BACKGROUND: Soluble fibers, including those from psyllium husk, have been shown to augment the cholesterol-lowering effects of a low-fat diet in persons with hypercholesterolemia. As evidence of this, the US Food and Drug Administration recently authorized the use of health claims on food products containing soluble fiber from psyllium that state that they are associated with a decreased risk of coronary heart disease. OBJECTIVE: This meta-analysis was conducted to more precisely define the hypolipidemic effects and safety of psyllium when used adjunctive to a low-fat diet in men and women with hypercholesterolemia. DESIGN: The 8 studies in the meta-analysis included a total of 384 and 272 subjects receiving psyllium or cellulose placebo, respectively. All studies evaluated the hypocholesterolemic effects of 10.2 g psyllium/d adjunctive to a low-fat diet for >/=8 wk in individuals with mild-to-moderate hypercholesterolemia after a low-fat diet lead-in phase lasting >/=8 wk. The safety and adverse events associated with psyllium consumption were summarized from pooled data of 19 clinical studies ranging from 6 wk to 6 mo in duration. RESULTS: Consumption of 10.2 g psyllium/d lowered serum total cholesterol by 4% (P < 0.0001), LDL cholesterol by 7% (P < 0.0001), and the ratio of apolipoprotein (apo) B to apo A-I by 6% (P < 0.05) relative to placebo in subjects already consuming a low-fat diet, with no effect on serum HDL or triacylglycerol concentrations. CONCLUSIONS: Psyllium supplementation significantly lowered serum total and LDL-cholesterol concentrations in subjects consuming a low-fat diet. Psyllium is well tolerated and safe when used adjunctive to a low-fat diet in individuals with mild-to-moderate hypercholesterolemia. DOI: 10.1093/ajcn/71.2.472 PMID: 10648260 [Indexed for MEDLINE]
11. Front Microbiol. 2025 Mar 25;16:1554484. doi: 10.3389/fmicb.2025.1554484. eCollection 2025. Effects of dietary fiber on the composition, function, and symbiotic interactions of intestinal microbiota in pre-weaned calves. Lu W(1), Yi X(1)(2), Ge Y(1), Zhang X(1), Shen K(1), Zhuang H(1), Deng Z(1), Liu D(3), Cao J(1), Ma C(1). Author information: (1)College of Veterinary Medicine, China Agricultural University, Beijing, China. (2)School of Chemistry, University of Bristol, Bristol, United Kingdom. (3)Hebei Shounong Modern Agricultural Technology Co., LTD., Dingzhou, China. INTRODUCTION: Dietary fiber plays a crucial role in maintaining gastrointestinal health. However, its protective effects on the intestinal health of calves remain to be fully elucidated. This study aimed to investigate the impact of dietary fiber supplementation on the intestinal microbiota of pre-weaned calves and its potential role in modulating microbial metabolic pathways. METHODS: A randomized controlled trial was conducted, enrolling 135 calves that were randomly assigned into three groups: (1) inulin supplementation, (2) psyllium husk powder (PHP) supplementation, and (3) a control group receiving no dietary fiber. Fecal microbiota samples were collected from calves without diarrhea at five time points (0, 7, 14, 28, and 56 days of age). Metagenomic sequencing was performed to analyze microbial composition and functional pathways. Additionally, a differential analysis of carbohydrate-active enzymes (CAZymes) was performed to evaluate the effect of dietary fiber on carbohydrate metabolism enzyme activity within the intestinal microbiota. RESULTS: Calves supplemented with dietary fiber exhibited a significant increase in the abundance of Bifidobacterium and Prevotella compared to the control group. These bacterial genera contributed to intestinal protection by modulating secondary bile acid metabolism and flavonoid metabolism pathways. CAZymes differential analysis revealed an increased abundance of carbohydrate metabolism enzymes in response to dietary fiber supplementation, with distinct microbial community compositions observed among different fiber treatments. Notably, at 56 days of age, calves fed PHP harbored intergeneric symbiotic clusters comprising Clostridium, Prevotella, and Bacteroides, suggesting a cooperative microbial network that may contribute to intestinal homeostasis. DISCUSSION: The findings of this study highlight the beneficial effects of dietary fiber on calf intestinal microbiota, particularly in enhancing microbial diversity and enzymatic activity related to carbohydrate metabolism. The observed microbial symbiosis in PHP-fed calves suggests a potential role in maintaining intestinal homeostasis. These insights provide a theoretical foundation for optimizing dietary interventions to promote gut health in calves during the transition period. Further research is warranted to explore the mechanistic interactions between dietary fiber, gut microbiota, and host health outcomes. Copyright © 2025 Lu, Yi, Ge, Zhang, Shen, Zhuang, Deng, Liu, Cao and Ma. DOI: 10.3389/fmicb.2025.1554484 PMCID: PMC11975667 PMID: 40201438 Conflict of interest statement: DL was employed by Hebei Shounong Modern Agricultural Technology Co., LTD. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
12. J Pediatr Gastroenterol Nutr. 2023 Jan 1;76(1):14-19. doi: 10.1097/MPG.0000000000003622. Epub 2022 Sep 22. Efficacy of Oral Psyllium in Pediatric Irritable Bowel Syndrome: A Double-Blind Randomized Control Trial. Menon J(1), Thapa BR(1), Kumari R(2), Puttaiah Kadyada S(1), Rana S(3), Lal SB(1). Author information: (1)From the Division of Paediatric Gastroenterology, Post Graduate Institute of Medical Education & Research, Chandigarh, India. (2)the Department of Gastroenterology, Post Graduate Institute of Medical Education & Research, Chandigarh, India. (3)the Division of Biochemistry, Department of Gastroenterology, Post Graduate Institute of Medical Education & Research, Chandigarh, India. Comment in J Pediatr Gastroenterol Nutr. 2023 Aug 1;77(2):e50-e51. doi: 10.1097/MPG.0000000000003813. J Pediatr Gastroenterol Nutr. 2023 Aug 1;77(2):e49-e50. doi: 10.1097/MPG.0000000000003814. OBJECTIVE: Pediatric irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder with variable response to various therapeutic agents. Psyllium has been proven to be effective in adults; however, there is no study in children. The objective of this study is to evaluate the efficacy of psyllium husk as compared to placebo in pediatric IBS patients. METHODS: In this double-blind randomized controlled trial, 43 children were assigned to psyllium arm (Group A) and 38 into placebo arm (Group B). Severity is assessed at baseline and after 4 weeks of treatment using IBS severity scoring scale (IBS-SSS) and classified into mild, moderate, and severe categories. Categorical data was compared with chi-square test and paired categorical variable was compared with McNemer test. RESULTS: Mean ages (±SD; in years) of Groups A and B were 9.87 (2.7) and 9.82 (3.17), respectively, with median duration of illness of 12 months. At baseline, type, severity, and parameters (IBS-SSS) of IBS were equally distributed in 2 groups. There was a significant reduction in median interquartile range (IQR) of total IBS-SSS in psyllium versus placebo [75 (42.5-140) vs 225 (185-270); P < 0.001] at 4 weeks. Similarly 43.9% in Group A versus 9.7% in Group B attained remission [IBS-SSS < 75 ( P < 0.0001)]. The mean difference in IBS-SSS between Group A and Group B was -122.85 with risk ratio of 0.64 (95% CI; 0.42-0.83; P = 0.001) and absolute risk reduction of 32% (NNT = 3). CONCLUSIONS: Psyllium husk is effective for the therapy of pediatric IBS when compared with placebo in short term. Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. DOI: 10.1097/MPG.0000000000003622 PMID: 36136861 [Indexed for MEDLINE] Conflict of interest statement: The authors report no conflicts of interest.
13. Nutrients. 2021 Nov 28;13(12):4298. doi: 10.3390/nu13124298. The Short-Term Effects and Tolerability of Low-Viscosity Soluble Fibre on Gastroparesis Patients: A Pilot Clinical Intervention Study. Suresh H(1)(2), Zhou J(1)(2), Ho V(1)(2)(3). Author information: (1)School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia. (2)Gastrointestinal Motility Disorders Unit, Western Sydney University, Campbelltown, NSW 2560, Australia. (3)University Medical Clinic of Camden & Campbelltown (UMCCC), Campbelltown, NSW 2560, Australia. Gastroparesis is a motility disorder that causes severe gastric symptoms and delayed gastric emptying, where the majority of sufferers are females (80%), with 29% of sufferers also diagnosed with Type-1 or Type-2 diabetes. Current clinical recommendations involve stringent dietary restriction and includes the avoidance and minimization of dietary fibre. Dietary fibre lowers the glycaemic index of food, reduces inflammation and provides laxation. Lack of dietary fibre in the diet can affect long-term gastrointestinal health. Our previously published rheological study demonstrated that "low-viscosity" soluble fibres could be a potentially tolerable source of fibre for the gastroparetic population. A randomised controlled crossover pilot clinical study was designed to compare Partially-hydrolysed guar gum or PHGG (test fibre 1), gum Arabic (test fibre 2), psyllium husk (positive control) and water (negative control) in mild-to-moderate symptomatic gastroparesis patients (requiring no enteral tube feeding). The principal aim of the study was to determine the short-term physiological effects and tolerability of the test fibres. In n = 10 female participants, post-prandial blood glucose, gastroparesis symptoms, and breath test measurements were recorded. Normalized clinical data revealed that test fibres PHGG and gum Arabic were able to regulate blood glucose comparable to psyllium husk, while causing far fewer symptoms, equivalent to negative control. The test fibres did not greatly delay mouth-to-caecum transit, though more data is needed. The study data looks promising, and a longer-term study investigating these test fibres is being planned. DOI: 10.3390/nu13124298 PMCID: PMC8704257 PMID: 34959850 [Indexed for MEDLINE] Conflict of interest statement: The authors declare that no financial interest or benefit has arisen from the direct applications of this research.
14. Front Nutr. 2021 Dec 7;8:756485. doi: 10.3389/fnut.2021.756485. eCollection 2021. A Preparatory Study for a Randomized Controlled Trial of Dietary Fiber Intake During Adult Pelvic Radiotherapy. Ahlin R(1), Bergmark K(1), Bull C(1), Devarakonda S(1), Landberg R(2), Sigvardsson I(1), Sjöberg F(3), Skokic V(1)(4)(5), Steineck G(1), Hedelin M(1)(6). Author information: (1)Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. (2)Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. (3)Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. (4)Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. (5)Department of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden. (6)Regional Cancer Center West, Sahlgrenska University Hospital, Gothenburg, Sweden. Background: Patients undergoing pelvic radiotherapy are often advised to omit fiber-rich foods from their diet to reduce the adverse effects of treatment. Scientific evidence supporting this recommendation is lacking, and recent studies on animals and humans have suggested that there is a beneficial effect of dietary fiber for the alleviation of symptoms. Randomized controlled studies on dietary fiber intake during pelvic radiotherapy of sufficient size and duration are needed. As preparation for such a large-scale study, we evaluated the feasibility, compliance, participation rate, and logistics and report our findings here in this preparatory study. Methods: In this preparatory study of a fiber intervention trial, Swedish gynecological cancer patients scheduled for radiotherapy were recruited between January 2019 and August 2020. During the intervention, the participants filled out questionnaires and used an application. They also consumed a fiber supplement at first in powder form, later in capsules. Blood- and fecal samples were collected. The study is registered in clinicaltrials.gov (https://clinicaltrials.gov/ct2/show/NCT04534075?cond=fidura&draw=2&rank=1). Results: Among 136 approached patients, 57 started the study and the participation rate for primary outcomes was 63% (third blood sample) and 65% (third questionnaire). Barely half of the participants provided fecal samples. Providing concise and relevant information to the patients at the right time was crucial in getting them to participate and stay in the study. The most common reasons for declining participation or dropping out were the expected burden of radiotherapy or acute side effects. Tailoring the ambition level to each patient concerning the collection of data beyond the primary endpoints was an important strategy to keep the dropout rate at an acceptable level. Using capsules rather than psyllium in powder form made it much easier to document intake and to create a control group. During the course of the preparatory study, we improved the logistics and for the last 12 participants included, the participation rate was 100% for the earliest primary outcome. Conclusion: A variety of adjustments in this preparatory study resulted in an improved participation rate, which allowed us to set a final protocol and proceed with the main study. Copyright © 2021 Ahlin, Bergmark, Bull, Devarakonda, Landberg, Sigvardsson, Sjöberg, Skokic, Steineck and Hedelin. DOI: 10.3389/fnut.2021.756485 PMCID: PMC8688914 PMID: 34950688 Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
15. Aging (Albany NY). 2021 Jun 3;13(11):15366-15383. doi: 10.18632/aging.203095. Epub 2021 Jun 3. The effects of psyllium husk on gut microbiota composition and function in chronically constipated women of reproductive age using 16S rRNA gene sequencing analysis. Yang C(1), Liu S(2), Li H(3), Bai X(2), Shan S(4), Gao P(5), Dong X(1). Author information: (1)Department of General Surgery, Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences), Taiyuan, China. (2)Graduate School, Shanxi Medical University, Taiyuan, China. (3)Shanxi Provincial Cancer Hospital, Taiyuan, China. (4)Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, China. (5)BGI Life Science Research Institution, Shenzhen, China. Erratum in Aging (Albany NY). 2022 Mar 30;14(6):2923. doi: 10.18632/aging.203991. Chronic constipation is a common gastrointestinal disorder that occurs in the elderly and in women. Psyllium husk is widely used to treat this condition. Recent studies have shown that psyllium husk can improve the clinical symptoms of constipation by regulating gut microbiota, but its clinical effects and potential mechanisms in constipated women of reproductive age have not been previously investigated. We compared fecal microbiota after treatment with placebo (n = 29) and psyllium husk (n = 25) using 16S ribosomal ribonucleic acid (rRNA) gene sequencing analysis. Psyllium husk relieved the symptoms of constipated women of reproductive age. Sequencing results showed that the psyllium husk group exhibited a different gut microbiota composition compared to that of the placebo group. Moreover, network analysis indicated more significant correlations and clustering of operational taxonomic units (OTUs) in the psyllium husk group. Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation analysis showed that the relative abundances of metabolism-related KEGG pathways were enriched in the psyllium husk group. In conclusion, these findings suggest that the composition of gut microbiota was altered and that symptoms of constipation were alleviated via psyllium husk intervention. The changes in metabolic function might be related to constipation. Furthermore, these studies are warranted to elucidate the potential metabolic mechanisms contributing to chronic constipation. DOI: 10.18632/aging.203095 PMCID: PMC8221300 PMID: 34081625 [Indexed for MEDLINE] Conflict of interest statement: CONFLICTS OF INTEREST: The authors declare that they have no conflicts of interest.
16. Medicine (Baltimore). 2018 Dec;97(51):e13765. doi: 10.1097/MD.0000000000013765. The efficacy of cervical spine phantoms for improving resident proficiency in performing ultrasound-guided cervical medial branch block: A prospective, randomized, comparative study. Kwon SY(1), Kim JW(2), Cho MJ(2), Al-Sinan AH(3), Han YJ(2), Kim YH(2). Author information: (1)Department of Anesthesiology and Pain Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon. (2)Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. (3)Department of Anesthesiology and Pain Medicine, Ministry of Health, Qatif Central Hospital, Alawjam, Saudi Arabia. BACKGROUND: Few studies have been conducted on the utility of cervical spine phantoms for practicing cervical procedures. Here, we describe a simple method for creating a cervical spine phantom and investigate whether the use of a gelatin-based phantom is associated with improved proficiency in performing ultrasound-guided cervical medial branch block. METHODS: A cervical spine phantom was prepared using a cervical spine model immersed in a mixture of gelatin and psyllium husk. In total, 27 participants, inexperienced in spinal ultrasonography, were enrolled and allocated to 1 of 2 groups (training group, n = 18; control group, n = 9). All participants were tested (test-1) following an introductory course of basic ultrasonography. Participants in the control group were tested again after 1 week (test-2). Those in the training group received a further individual 3-hour training session, and were tested again after 1 week (test-2). RESULTS: The mean performance score in test-1 was 62.5 ± 10.1 points in the training group and 62.3 ± 4.1 points in the control group [95% confidence interval (95% CI) -5.5 to 5.8; P = .954]. In test-2, the mean score was 86.8 ± 6.5 points and 59.9 ± 4.4 points in the training and control groups, respectively (95% CI 21.9-31.8; P < .001). The mean time required to complete test-1 was 84.6 ± 26.6 seconds in training group and 90.7 ± 43.9 seconds in the control group (95% CI -34.0 to 21.7; P = .653); in test-2, the time required was 56.6 ± 27.9 and 91.2 ± 43.8 seconds (95% CI -63.0 to -6.2; P = .019), respectively. Interobserver reliability showed excellent agreement based on the intraclass correlation coefficient, and moderate to almost perfect agreement by kappa statistics. CONCLUSION: Training using a gelatin-based cervical spine phantom helps novices acquire the skills necessary to perform ultrasound-guided cervical medial branch blocks. DOI: 10.1097/MD.0000000000013765 PMCID: PMC6320022 PMID: 30572526 [Indexed for MEDLINE] Conflict of interest statement: There are no conflicts of interest to report.
17. Exp Physiol. 2018 Oct;103(10):1302-1308. doi: 10.1113/EP087058. Epub 2018 Aug 19. Gastric cooling and menthol cause an increase in cardiac parasympathetic efferent activity in healthy adult human volunteers. Kazadi LC(1), Fletcher J(1), Barrow PA(1). Author information: (1)Department of Biomedical Science and Physiology, School of Sciences, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton, UK. NEW FINDINGS: What is the central question of this study? How do gastric stretch and gastric cooling stimuli affect cardiac autonomic control? What is the main finding and its importance? Gastric stretch causes an increase in cardiac sympathetic activity. Stretch combined with cold stimulation result in an elimination of the sympathetic response to stretch and an increase in cardiac parasympathetic activity, in turn resulting in a reduction in heart rate. Gastric cold stimulation causes a shift in sympathovagal balance towards parasympathetic dominance. The cold-induced bradycardia has the potential to decrease cardiac workload, which might be significant in individuals with cardiovascular pathologies. ABSTRACT: Gastric distension increases blood pressure and heart rate in young, healthy humans, but little is known about the effect of gastric stretch combined with cooling. We used a randomized crossover study to assess the cardiovascular responses to drinking 300 ml of ispaghula husk solution at either 6 or 37°C in nine healthy humans (age 24.08 ± 9.36 years) to establish the effect of gastric stretch with and without cooling. The effect of consuming peppermint oil capsules to activate cold thermoreceptors was also investigated. The ECG, respiratory movements and continuous blood pressure were recorded during a 5 min baseline period, followed by a 115 min post-drink period, during which 5 min epochs of data were recorded. Cardiac autonomic activity was assessed using time and frequency domain analyses of respiratory sinus arrhythmia to quantify parasympathetic autonomic activity, and corrected QT (QTc) interval analysis to quantify sympathetic autonomic activity. Gastric stretch only caused a significant reduction in QTc interval lasting up to 15 min, with a concomitant but non-significant increase in heart rate, indicating an increased sympathetic cardiac tone. The additional effect of gastric cold stimulation was significantly to reduce heart rate for up to 15 min, elevate indicators of cardiac parasympathetic tone and eliminate the reduction in QTc interval seen with gastric stretch only. Stimulation of gastric cold thermoreceptors with menthol also caused a significant reduction in heart rate and concomitant increase in the root mean square of successive differences. These findings indicate that gastric cold stimulation causes a shift in the sympathovagal balance of cardiac control towards a more parasympathetic dominant pattern. © 2018 The Authors. Experimental Physiology © 2018 The Physiological Society. DOI: 10.1113/EP087058 PMID: 30070742 [Indexed for MEDLINE]
18. ANZ J Surg. 2006 Aug;76(8):718-21. doi: 10.1111/j.1445-2197.2006.03838.x. Randomized, controlled study comparing sitz-bath and no-sitz-bath treatments in patients with acute anal fissures. Gupta P(1). Author information: (1)Gupta Nursing Home, Nagpur, Maharashtra, India. drpjg_ngp@sancharnet.in AIM: To determine the efficacy and safety of sitz baths in the management of acute anal fissures. METHOD: Individual patients were randomized to either receive sitz baths or no sitz baths for 4 weeks in addition to oral psyllium husk. Patients were asked to soak their hips and buttocks in a tub containing plain lukewarm water for 10 min, once after defecation in the morning and again at bedtime. Each week, the patients were called to assess pain scores and healing of fissures, whereas the level of satisfaction was recorded at the end of 4 weeks. Main outcome measures were validated pain scores and levels of satisfaction. RESULTS: Fifty-eight subjects were recruited for this study. In all, 52 of them completed the trial (27 in the sitz bath group and 25 in the control group). Although the pain score was lesser in the sitz bath group than in the control group, it failed to reach statistical significance. There were no significant differences in fissure healing between the two groups over the 4-week study period. However, patients in the sitz bath group reported better satisfaction levels than the control group (P < 0.01). Although no serious adverse effects were observed, two patients from sitz bath group developed perianal skin rash. CONCLUSION: This study suggests that sitz baths improve patient satisfaction in acute anal fissures. However, the healing and overall pain relief was not significant enough to attract attention. It was also found to be associated with adverse effects in few patients. DOI: 10.1111/j.1445-2197.2006.03838.x PMID: 16916391 [Indexed for MEDLINE]
19. J Ethnopharmacol. 2005 Nov 14;102(2):202-7. doi: 10.1016/j.jep.2005.06.042. Epub 2005 Sep 8. Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients. Ziai SA(1), Larijani B, Akhoondzadeh S, Fakhrzadeh H, Dastpak A, Bandarian F, Rezai A, Badi HN, Emami T. Author information: (1)Department of Pharmacology, Institute of Medicinal Plants, ACECR, No. 97 Bozorgmehr Street, Qods Street, Enghelab Avenue, P.O. Box 13145-1446 Tehran, Iran. saziai@gmail.com Psyllium is a bulk-forming laxative and is high in both fiber and mucilage. The beneficial effect of dietary fiber in the management of type II diabetes, has not been totally demonstrated. The purpose of this study was to determine the plasma-lowering effects of 5.1g b.i.d. of psyllium husk fiber, as an adjunct to dietary and drug therapy on lipid and glucose levels, in patients with type II diabetes. Patients were randomly selected from an outpatient clinic of primary care to participate in a double-blind placebo-controlled study in which Plantago ovata Forsk., or placebo was given in combination with their anti-diabetic drugs. Forty-nine subjects were included in the study that were given diet counseling before the study and then followed for 8 weeks in the treatment period. Fasting plasma glucose (FBS) was measured every 2 weeks, and total plasma cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglyceride (TG), and insulin levels were measured every 4 weeks. Glycosylated hemoglobin (HbA1c) was also measured at the beginning and ending of the study. The test products (psyllium or placebo) were supplied to subjects in identically labeled foil packets containing a 5.1g dose of product, to consume two doses per day, half an hour before breakfast and dinner. Both products were well tolerated, with no serious adverse events related to treatment was reported in either. Better gastric tolerance to metformin was recorded in the psyllium group. FBS, and HbA1c, showed a significant reduction (p<0.05), whereas HDL-C increased significantly (p<0.05) following psyllium treatment. LDL/HDL ratio was significantly decreased (p<0.05). Our results show that 5.1g b.i.d. of psyllium for persons with type II diabetes is safe, well tolerated, and improves glycemic control. DOI: 10.1016/j.jep.2005.06.042 PMID: 16154305 [Indexed for MEDLINE]
20. Drugs R D. 2005;6(4):221-5. doi: 10.2165/00126839-200506040-00004. A randomised, controlled comparison of low-dose polyethylene glycol 3350 plus electrolytes with ispaghula husk in the treatment of adults with chronic functional constipation. Wang HJ(1), Liang XM, Yu ZL, Zhou LY, Lin SR, Geraint M. Author information: (1)Beijing Friendship Hospital, Beijing, People's Republic of China. DOI: 10.2165/00126839-200506040-00004 PMID: 15991881 [Indexed for MEDLINE]
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