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Effect of a Nutraceutical Combination on Oxidative Stress Biomarkers in Healthy Subjects and Patients with Alzheimer's Disease.

1. Nutrients. 2026 Feb 27;18(5):789. doi: 10.3390/nu18050789. Effect of a Nutraceutical Combination on Oxidative Stress Biomarkers in Healthy Subjects and Patients with Alzheimer's Disease. Jastrząb R(1), Małecki A(2), Kmiecik-Małecka E(2)(3), Gorzkowska A(4), Kubas K(1), Widłak-Kargul J(1), Wol

Native Brazilian fruits: postprandial glycemic control and carbohydrate-enzyme inhibition - insights from a randomized crossover clinical trial.

2. Food Funct. 2025 Apr 14;16(8):3075-3089. doi: 10.1039/d4fo03749a. Native Brazilian fruits: postprandial glycemic control and carbohydrate-enzyme inhibition - insights from a randomized crossover clinical trial. Duarte IAE(1), Araújo TMAM(1), Fraga LN(1), Giuntini EB(1), Sakiyama VK(1), Sprici

The Effects of a Food Supplement, Based on Co-Micronized Palmitoylethanolamide (PEA)-Rutin and Hydroxytyrosol, in Metabolic Syndrome Patients: Preliminary Results.

3. Nutrients. 2025 Jan 23;17(3):413. doi: 10.3390/nu17030413. The Effects of a Food Supplement, Based on Co-Micronized Palmitoylethanolamide (PEA)-Rutin and Hydroxytyrosol, in Metabolic Syndrome Patients: Preliminary Results. Cornali K(1), Di Lauro M(2), Marrone G(2), Masci C(2), Montalto G(3),

Effect of a 12-Week Polyphenol Rutin Intervention on Markers of Pancreatic β-Cell Function and Gut Microbiota in Adults with Overweight without Diabetes.

4. Nutrients. 2023 Jul 28;15(15):3360. doi: 10.3390/nu15153360. Effect of a 12-Week Polyphenol Rutin Intervention on Markers of Pancreatic β-Cell Function and Gut Microbiota in Adults with Overweight without Diabetes. Mathrani A(1)(2), Yip W(1)(2)(3), Sequeira-Bisson IR(1)(2)(3), Barnett D(4), S

The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial.

5. Phytother Res. 2023 Jan;37(1):271-284. doi: 10.1002/ptr.7611. Epub 2022 Sep 13. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients

Efficacy of a standardized herbal product from Pistacia atlantica subsp. Kurdica in type 2 diabetic patients with hyperlipidemia: A triple-blind randomized clinical trial.

6. Complement Ther Clin Pract. 2022 Aug;48:101613. doi: 10.1016/j.ctcp.2022.101613. Epub 2022 Jun 8. Efficacy of a standardized herbal product from Pistacia atlantica subsp. Kurdica in type 2 diabetic patients with hyperlipidemia: A triple-blind randomized clinical trial. Majd FS(1), Talebi SS(

Clinical effect of alfacalcidol in children with Henoch-Schönlein purpura: a prospective randomized controlled trial.

7. Zhongguo Dang Dai Er Ke Za Zhi. 2021 Aug 15;23(8):797-801. doi: 10.7499/j.issn.1008-8830.2105136. Clinical effect of alfacalcidol in children with Henoch-Schönlein purpura: a prospective randomized controlled trial. [Article in Chinese, English; Abstract available in Chinese from the publishe

A new original nutraceutical formulation ameliorates the effect of Tadalafil on clinical score and cGMP accumulation.

8. Arch Ital Urol Androl. 2021 Jun 28;93(2):221-226. doi: 10.4081/aiua.2021.2.221. A new original nutraceutical formulation ameliorates the effect of Tadalafil on clinical score and cGMP accumulation. Mirone V(1), Napolitano L(2), D'Emmanuele di Villa Bianca R(3), Mitidieri E(4), Sorrentino R(5)

Evaluation of the underutilized Malpighia glabra L. fruits as a future functional food: nutritional composition, phenolic profile, biological activities, and synergistic effects with pharmaceutical drugs.

9. Food Funct. 2026 Apr 27;17(8):3734-3748. doi: 10.1039/d5fo03782d. Evaluation of the underutilized Malpighia glabra L. fruits as a future functional food: nutritional composition, phenolic profile, biological activities, and synergistic effects with pharmaceutical drugs. Kemsawasd V(1), Thangs

The active components of the Danshen-Shanzha herb-pair exert a protective effect on MASLD by synergistically promoting fatty acid oxidation via the activation of PPARα, Plin-5 and Plin-2.

10. J Ethnopharmacol. 2026 May 10;362:121374. doi: 10.1016/j.jep.2026.121374. Epub 2026 Feb 12. The active components of the Danshen-Shanzha herb-pair exert a protective effect on MASLD by synergistically promoting fatty acid oxidation via the activation of PPARα, Plin-5 and Plin-2. Yang Y(1),

Flavonoids identified in Australian Terminalia inhibit methicillin and β-lactam-resistant pathogens, exhibit efflux pump inhibitory activity, and potentiate conventional antibiotics.

11. Microbiol Spectr. 2026 Mar 3;14(3):e0237425. doi: 10.1128/spectrum.02374-25. Epub 2026 Jan 16. Flavonoids identified in Australian Terminalia inhibit methicillin and β-lactam-resistant pathogens, exhibit efflux pump inhibitory activity, and potentiate conventional antibiotics. Jawad Yousaf

Phytochemical Evaluation of Terminalia catappa L. Extracts with Antibacterial and Antibiotic Potentiation Activities Against β-Lactam Drug-Resistant Bacteria.

12. Int J Mol Sci. 2025 Dec 23;27(1):177. doi: 10.3390/ijms27010177. Phytochemical Evaluation of Terminalia catappa L. Extracts with Antibacterial and Antibiotic Potentiation Activities Against β-Lactam Drug-Resistant Bacteria. Zai MJ(1)(2), Cheesman MJ(3), Cock IE(1)(2). Author information: (1)

Synergistic Phenolic Compounds in Medicinal Plant Extracts: Enhanced Furin Protease Inhibition via Solvent-Specific Extraction from Lamiaceae and Asteraceae Families.

13. Molecules. 2025 Aug 22;30(17):3450. doi: 10.3390/molecules30173450. Synergistic Phenolic Compounds in Medicinal Plant Extracts: Enhanced Furin Protease Inhibition via Solvent-Specific Extraction from Lamiaceae and Asteraceae Families. Üzer FB(1), Helvacı N(1), Elmastaş M(1). Author informat

Synergistic and antagonistic contributions of main components to the bioactivity profile of Anethum graveolens extract.

14. Sci Rep. 2025 Jul 1;15(1):21465. doi: 10.1038/s41598-025-07297-8. Synergistic and antagonistic contributions of main components to the bioactivity profile of Anethum graveolens extract. Kesti Usta S(1), Yalçın E(2)(3), Çavuşoğlu K(4). Author information: (1)Department of Biology, Institute o

Flavonoids Identified in Terminalia spp. Inhibit Gastrointestinal Pathogens and Potentiate Conventional Antibiotics via Efflux Pump Inhibition.

15. Molecules. 2025 May 23;30(11):2300. doi: 10.3390/molecules30112300. Flavonoids Identified in Terminalia spp. Inhibit Gastrointestinal Pathogens and Potentiate Conventional Antibiotics via Efflux Pump Inhibition. Zai MJ(1)(2), Cheesman MJ(3), Cock IE(1)(2). Author information: (1)Centre for P

Synergistic Effects and Mechanisms of Action of Rutin with Conventional Antibiotics Against Escherichia coli.

17. Int J Mol Sci. 2024 Dec 21;25(24):13684. doi: 10.3390/ijms252413684. Synergistic Effects and Mechanisms of Action of Rutin with Conventional Antibiotics Against Escherichia coli. Yi L(1)(2), Bai Y(1), Chen X(1)(2), Wang W(1), Zhang C(1), Shang Z(1)(2), Zhang Z(1)(2), Li J(1)(2), Cao M(2), Zh

Rutin Synergizes with Colistin to Eradicate Salmonellosis in Mice by Enhancing the Efficacy and Reducing the Toxicity.

21. J Agric Food Chem. 2025 Jan 8;73(1):438-449. doi: 10.1021/acs.jafc.4c06751. Epub 2024 Dec 19. Rutin Synergizes with Colistin to Eradicate Salmonellosis in Mice by Enhancing the Efficacy and Reducing the Toxicity. Luo Y(1), He B(1), Li ZP(1), Zhong Q(1), Liu YC(1), Zhang HY(1), Li Y(1), Yan

Synergistic potential of Bauhinia holophylla leaf extracts with conventional antifungals in the inhibition of Candida albicans: A new approach for the treatment of oral candidiasis.

42. Arch Oral Biol. 2025 Feb;170:106133. doi: 10.1016/j.archoralbio.2024.106133. Epub 2024 Nov 16. Synergistic potential of Bauhinia holophylla leaf extracts with conventional antifungals in the inhibition of Candida albicans: A new approach for the treatment of oral candidiasis. Rosa SO(1), Al

Yerba Mate (Ilex paraguariensis) and Rheumatoid Arthritis: A Systematic Review of Mechanistic and Clinical Evidence.

4. Nutrients. 2025 Dec 10;17(24):3853. doi: 10.3390/nu17243853. Yerba Mate (Ilex paraguariensis) and Rheumatoid Arthritis: A Systematic Review of Mechanistic and Clinical Evidence. Cassotta M(1)(2), Cao Q(3)(4), Hu H(3)(4), Martinez CR(3)(4), Dzul Lopez LA(1)(5)(6), Gracia Villar S(1)(5)(7), Bat

Use of Naringinase to Modify the Sensory Quality of Foods and Increase the Bioavailability of Flavonoids: A Systematic Review.

16. Molecules. 2025 May 29;30(11):2376. doi: 10.3390/molecules30112376. Use of Naringinase to Modify the Sensory Quality of Foods and Increase the Bioavailability of Flavonoids: A Systematic Review. Bodakowska-Boczniewicz J(1), Garncarek Z(1). Author information: (1)Department of Biotechnology a

Rutin-Associated Hepatoprotection: A Review of Mechanisms and Therapeutic Prospects.

44. Basic Clin Pharmacol Toxicol. 2025 Jun;136(6):e70042. doi: 10.1111/bcpt.70042. Rutin-Associated Hepatoprotection: A Review of Mechanisms and Therapeutic Prospects. Feng Y(1), Peng L(1), Liu X(1), Zheng Q(1), Qian M(1), Deng M(1), Peng J(2), Li Y(1), Lin L(1), Peng Q(1). Author information:

Utility of venoactive compounds in post-thrombotic syndrome: A systematic review.

50. J Vasc Surg Venous Lymphat Disord. 2025 Jul;13(4):102228. doi: 10.1016/j.jvsv.2025.102228. Epub 2025 Mar 16. Utility of venoactive compounds in post-thrombotic syndrome: A systematic review. Gloviczki ML(1), Stoughton J(2), Puggioni A(3), Gloviczki P(4), Raffetto JD(5). Author information:

Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus.

44. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul;398(7):8215-8240. doi: 10.1007/s00210-025-03888-4. Epub 2025 Feb 27. Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus. Faysal M(1), Al Amin M(2), Zehravi M(3), Sweilam SH(4)(5), Arjun UVNV(6), Gupta JK(7

Quercetin- and rutin-based nano-formulations for cancer treatment: A systematic review of improved efficacy and molecular mechanisms.

39. Phytomedicine. 2022 Mar;97:153909. doi: 10.1016/j.phymed.2021.153909. Epub 2021 Dec 28. Quercetin- and rutin-based nano-formulations for cancer treatment: A systematic review of improved efficacy and molecular mechanisms. Ghanbari-Movahed M(1), Mondal A(2), Farzaei MH(3), Bishayee A(4). Aut

The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review.

42. Pharmacol Res. 2021 Dec;174:105919. doi: 10.1016/j.phrs.2021.105919. Epub 2021 Oct 1. The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review. Cao Y(1), Xie L(1), Liu K(1), Liang Y(1), Dai X(1), Wang X(1), Lu J(1), Zhang X(1), Li X(2). Author information: (1)Sch

Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review.

42. Curr Top Med Chem. 2021;21(12):1067-1095. doi: 10.2174/1568026621666210509161059. Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review. Egbuna C(1), Awuchi CG(2), Kushwaha G(3), Rudrapal M(4), Patrick-Iwuanyanwu KC(1), Singh O(5), Odoh UE(6), Khan J(7), Jeevan

Phlebotonics for venous insufficiency.

1. Cochrane Database Syst Rev. 2020 Nov 3;11(11):CD003229. doi: 10.1002/14651858.CD003229.pub4. Phlebotonics for venous insufficiency. Martinez-Zapata MJ(1), Vernooij RW(2), Simancas-Racines D(3), Uriona Tuma SM(4), Stein AT(5), Moreno Carriles RMM(6), Vargas E(7), Bonfill Cosp X(8). Author inf

Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies.

16. Nutrients. 2020 Sep 23;12(10):2907. doi: 10.3390/nu12102907. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Gandhi GR(1)(2)(3), Vasconcelos ABS(4), Wu DT(5), Li HB(6), Antony PJ(7), Li H(1)(2),