비타민C+E (황반변성)
Vitamin C + E (AMD)
📚 관련 논문 (23편)
1. Cochrane Database Syst Rev. 2017 Jul 30;7(7):CD000253. doi: 10.1002/14651858.CD000253.pub4. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Evans JR(1), Lawrenson JG. Author information: (1)Cochrane Eyes and Vision, ICEH, London School of Hygiene
2. Cochrane Database Syst Rev. 2012 Nov 14;11:CD000254. doi: 10.1002/14651858.CD000254.pub3. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Evans JR(1), Lawrenson JG. Author information: (1)Cochrane Eyes and Vision Group, ICEH, Londo
3. Cochrane Database Syst Rev. 2012 Jun 13;(6):CD000253. doi: 10.1002/14651858.CD000253.pub3. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Evans JR(1), Lawrenson JG. Author information: (1)Cochrane Eyes and Vision Group, ICEH, London School of Hyg
4. Eye (Lond). 2008 Jun;22(6):751-60. doi: 10.1038/eye.2008.100. Epub 2008 Apr 18. Antioxidant supplements to prevent or slow down the progression of AMD: a systematic review and meta-analysis. Evans J(1). Author information: (1)International Centre for Eye Health, London School of Hygiene and T
5. BMJ. 2007 Oct 13;335(7623):755. doi: 10.1136/bmj.39350.500428.47. Epub 2007 Oct 8. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. Chong EW(1), Wong TY, Kreis AJ, Simpson JA, Guymer RH. Author information: (1)Centre for Ey
6. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD000254. doi: 10.1002/14651858.CD000254.pub2. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Evans JR(1). Author information: (1)London School of Hygiene & Tropical Medicine, Internatio
7. Ophthalmology. 2025 Jan;132(1):14-29. doi: 10.1016/j.ophtha.2024.07.014. Epub 2024 Jul 16. Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration. Keenan TDL(1), Agrón E(2), Keane PA(3), Domalpally A(4), Chew EY(
8. Cochrane Database Syst Rev. 2023 Sep 13;9(9):CD000254. doi: 10.1002/14651858.CD000254.pub5. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Evans JR(1), Lawrenson JG(2). Author information: (1)Centre for Public Health, Internationa
9. Acta Ophthalmol. 2022 Dec;100(8):e1541-e1552. doi: 10.1111/aos.15191. Epub 2022 Jun 13. What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review. Pameijer EM(#)(1), Heus P(#)(2), Damen JAA(2), Spijker R(2), Hooft L(2), Ri
1. Nutrients. 2026 Apr 17;18(8):1274. doi: 10.3390/nu18081274. The Role of Dietary Supplements in the Treatment of Endometriosis: A Critical Review. Wójtowicz M(1), Małek P(2), Olszanecka-Glinianowicz M(2). Author information: (1)Clinical Department of Gynecology and Obstetrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland. (2)Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. Background: There is a growing number of studies suggesting the effectiveness of dietary supplements in preventing and treating endometriosis. It has been suggested that deficiencies in vitamins D and E as well as zinc are associated with the increased risk of endometriosis development. Beneficial effects of magnesium, curcumin, resveratrol and epigallocatechin-3-gallate were found in experimental animal studies. A reduction in pain related to endometriosis was shown in women using omega-3 and alpha-lipoic acid. Meanwhile, decreasing endometriotic lesion size after the supplementation of omega-3, N-acetylcysteine, vitamin C and epigallocatechin-3-gallate was observed in animal and human studies. Thus, the aim of this critical review was to summarize the available data describing the effects of dietary supplements used in the treatment of endometriosis. Material and Methods: The PubMed, Embase, Cochrane, and Web of Science databases were searched for related studies until 15 December 2025. Finally, 34 studies were included in the synthesis. Results: Of these 34 studies, only 23 were randomized, placebo-controlled trials. There have been no RCTs evaluating the effectiveness of vitamin E, zinc, alpha-LA, EGCG and DIM in the treatment of endometriosis. Single studies evaluating the effectiveness of vitamin C, magnesium, resveratrol, NAC and PEA with PLD have not confirmed it. Meanwhile single studies evaluating the effectiveness of selenium, propolis and quercetin have confirmed it. Of the four studies assessing the effectiveness of vitamin D, two confirmed it and two did not; of the two studies assessing probiotics, one confirmed its effectiveness and one did not; of the two studies assessing curcumin, one confirmed its effectiveness and one did not; and of the three studies assessing omega-3, two confirmed its effectiveness and one did not. All four RCTs assessing the combination of vitamins C and E confirmed their effectiveness. Conclusions: Despite encouraging observations from experimental studies, the results of RCTs are less encouraging and do not allow for the formulation of recommendations concerning the use of supplements in the treatment of endometriosis symptoms according to EBM. DOI: 10.3390/nu18081274 PMID: 42075089 [Indexed for MEDLINE]
2. Aging Clin Exp Res. 2026 Feb 20;38(1):94. doi: 10.1007/s40520-026-03344-0. Trends and determinants of dietary supplement use and potential drug- supplement interactions in older adults: a 16-years follow-up in the Tehran lipid and glucose study. Bahadoran Z(1), Nozari Z(2), Azizi F(3). Author information: (1)Micronutrient Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 24, Sahid-Erabi St, Yemen St, Chamran Exp, 19395-4763, Tehran, Iran. z.bahadoran@sbmu.ac.ir. (2)Micronutrient Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 24, Sahid-Erabi St, Yemen St, Chamran Exp, 19395-4763, Tehran, Iran. (3)Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. azizi@sbmu.ac.ir. AIM: This study aimed to examine the trends and determinants of dietary supplement use and to assess the prevalence and predictors of potential drug-supplement interactions among older adults over a 16-year follow-up. METHODS: This repeated cross-sectional study included adults aged ≥ 50 years who participated in the third (2006–2008; n = 3,484), fourth (2009–2011; n = 4,020), fifth (2012–2014; n = 4,342), sixth (2015–2017; n = 4,598), and seventh (2018–2022; n = 4,750) examinations of the Tehran Lipid and Glucose Study (TLGS). Information on dietary supplement use, including individual vitamin supplements and prescription medication use was collected using standardized questionnaires. Trends in supplement use and participant characteristics were evaluated across study phases. Clinically relevant mild-to-moderate potential drug-supplement interactions were defined as the concurrent use of specific dietary supplements and commonly prescribed medications and were classified according to Stockley’s framework. Multivariable logistic regression models were used to identify factors associated with dietary supplement use and potential drug-supplement interactions in the 2018–2022 examination. RESULTS: Over 16 years, dietary supplement use increased more than 2-fold from 10.4% to 21.1%, mainly from increases in thiamin (2.2% to 13.4%), cobalamin (1.8% to 9.8%), vitamin C (1.3% to 7.9%), vitamin E (1.8% to 8.7%), and zinc (0.2% to 3.3%). Female sex, higher education, and diabetes were associated with higher likelihood of supplement use. In 2018–2022, 4.8% of participants had potential drug-supplement interactions, most commonly vitamin E with aspirin (2.3%) and magnesium or potassium with antihypertensive medications. The likelihood of potential drug-supplement interactions was higher in women (OR = 2.03, 95%CI = 1.61–2.56), participants with primary education (OR = 1.45, 95% CI = 1.09–1.96), smokers (OR = 1.50, 95%CI = 1.07–2.12), and individuals with diabetes (OR = 2.80, 95%CI = 2.13–3.68), hypertension (OR = 2.20, 95%CI = 1.78–2.73), chronic kidney disease (OR = 2.35, 95%CI = 1.88–2.94), or multimorbidity (OR = 2.46, 95%CI = 1.85–3.26). CONCLUSION: Over 16 years, supplement use increased among older adults, especially B-complex vitamins, vitamin C, vitamin E, and zinc, with a low but clinically relevant prevalence of drug-supplement interactions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-026-03344-0. DOI: 10.1007/s40520-026-03344-0 PMCID: PMC12979372 PMID: 41714537 Conflict of interest statement: Declarations. Competing interests: The authors declare no competing interests. Human Ethics and Consent to Participate: The study protocol was approved by the ethics research council of the Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Written informed consent was obtained from all participants (Ethics code: IR.SBMU.ENDOCRINE.REC.1404.087). The study was conducted in accordance with the guidelines outlined in the Declaration of Helsinki. Clinical trial number: Not applicable. Consent to publish: Not applicable.
3. Int J Mol Sci. 2026 Feb 2;27(3):1476. doi: 10.3390/ijms27031476. Therapeutic Effects of Vitamins in Endometriosis Patients: A Systematic Review of Randomized Controlled Trials. Tsokkou S(1), Matsas A(2), Konstantinidis I(1), Karopoulou E(3), Papamitsou T(4), Stamoula E(5). Author information: (1)Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. (2)Laboratory of Experimental Surgery and Surgical Research 'N.S. Christeas', Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. (3)Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, 76 Vasilissis Sofias Avenue, 11528 Athens, Greece. (4)Laboratory of Histology-Embryology, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. (5)Department of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. Endometriosis is a chronic, estrogen-dependent inflammatory condition affecting approximately 10% of women of reproductive age worldwide. It is characterized by the presence of endometrial-like tissue outside the uterine cavity, which frequently results in dysmenorrhea, chronic pelvic pain, dyspareunia, and infertility. While hormonal medications and surgical procedures are common treatments, they are often constrained by adverse effects and high recurrence rates. The aim was to systematically identify, critically appraise, and synthesize randomized controlled trials evaluating vitamin D, C, and E supplementation in women with endometriosis, focusing on their effects on pelvic pain, dysmenorrhea, dyspareunia, quality of life, oxidative and inflammatory biomarkers, and fertility-related outcomes, and to highlight methodological gaps that can inform future research and integrated therapeutic strategies. Following PRISMA guidelines, seven eligible RCTs were identified from databases including PubMed, Scopus, and ScienceDirect. The quality of these studies was assessed using the Jadad Scoring System and Cochrane RoB 2 tool. High-dose supplementation of vitamin D (50,000 IU) was found to significantly reduce pelvic pain and improve biochemical markers such as hs-CRP and total antioxidant capacity (TAC). Vitamin D appears to modulate endometrial pathways by reducing active β-catenin protein activity, which may disrupt signaling associated with lesion invasion and survival. Additionally, combined Vitamin C and E therapy (typically 1000 mg/day of Vitamin C and 800 IU/day of Vitamin E) acts synergistically to scavenge free radicals. This intervention significantly decreased oxidative stress markers, including malondialdehyde (MDA) and reactive oxygen species (ROS). Patients reported significant improvements in symptoms, including a 43% reduction in daily pelvic pain and a 37% reduction in dysmenorrhea. Despite physiological improvements, there was no statistically significant increase in pregnancy rates observed across the trials. Vitamin supplementation with D, C, and E represents a safe, low-cost adjunct therapy that can effectively mitigate endometriosis-related oxidative stress and pelvic pain. While these vitamins show promise for symptom relief, further research with larger sample sizes is required to determine their long-term impact on fertility outcomes and lesion regression. DOI: 10.3390/ijms27031476 PMCID: PMC12898241 PMID: 41683896 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
4. Nutr Rev. 2026 Feb 1;84(2):235-245. doi: 10.1093/nutrit/nuaf133. Effects of Vitamin C and/or E Supplementation on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes: A Systematic Review and Subgroup Meta-analysis. Aragón-Vela J(1), Huertas JR(2), Casuso RA(3). Author information: (1)Department of Health Sciences, Area of Physiology, University of Jaén, 23071 Jaén, Spain. (2)Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, 18071 Granada, Spain. (3)Department of Health Sciences, Universidad Loyola Andalucía, 14004 Córdoba, Spain. CONTEXT: Type 2 diabetes (T2D) is one of the fastest-growing global health emergencies of the 21st century. However, high antioxidant capacity of supplementation of vitamin C and/or E was inversely associated with insulin resistance. However, each antioxidant possesses a distinct biological function that may be influenced by both dosage and duration of supplementation, potentially resulting in significantly different effects. OBJECTIVE: This meta-analysis aimed to evaluate whether vitamin C, vitamin E, or their combination is more effective in improving glycemic control, blood lipids, and blood pressure in individuals with T2D. DATA SOURCES AND DATA EXTRACTION: A systematic search was conducted in PubMed, Scopus, and Web of Science databases for randomized clinical trials, identifying 52 studies (n = 1425 participants). DATA ANALYSIS: Random-effects models were used to assess the effects of vitamin C and/or E supplementation on glycemic control, blood lipid levels, and blood pressure. These findings indicate that supplementation with vitamin C, vitamin E, or their combination has a comparable effect on glycemic index values, systolic blood pressure, and blood lipid profiles. However, a significant reduction in systolic blood pressure was observed only with vitamin C and combined vitamin C + E supplementation. Additionally, a significant increase in high-density-lipoprotein (HDL) levels was noted exclusively with the combined vitamin C + E supplementation. CONCLUSION: Consequently, supplementation with vitamin C, vitamin E, and their combination (C + E) exhibited differing effects on HDL levels and systolic blood pressure. However, their effects on glycemic control, diastolic blood pressure, and blood lipids other than HDL were comparable. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42023399366. © The Author(s) 2025. Published by Oxford University Press on behalf of the International Life Sciences Institute. DOI: 10.1093/nutrit/nuaf133 PMCID: PMC12793614 PMID: 41521729 [Indexed for MEDLINE] Conflict of interest statement: None declared.
5. Clin Nutr ESPEN. 2025 Oct;69:794-801. doi: 10.1016/j.clnesp.2025.08.037. Epub 2025 Sep 4. Effects of antioxidants on oxidative stress in adult patients with coronary artery disease: A systematic review. Alhusban IM(1), Chung ML(2), Biddle M(3). Author information: (1)College of Nursing, University of Kentucky, 751 Rose Street Lexington, KY 40536, USA. Electronic address: imal230@uky.edu. (2)School of Nursing, Vanderbilt University, 2201 West End Ave, Nashville, TN 37235, USA. (3)College of Nursing, University of Kentucky, 751 Rose Street Lexington, KY 40536, USA. BACKGROUND: Oxidative stress (OS) accelerates the pathogenesis of coronary artery disease (CAD) by contributing to atherosclerotic plaque formation. Current research indicates that antioxidants can mitigate OS by reducing the production of free radicals. Despite many studies that have tested the effects of antioxidants on oxidative stress in patients with CAD, the literature still lacks an updated and comprehensive systematic review. The aim of this study was to identify the effects of administering exogenous antioxidants on OS levels among adult patients with CAD. METHODS: A systematic review searched PubMed, Medline, and CINAHL for randomized controlled trials (RCTs) published between January 2013 and May 2025, which examined antioxidants to lower OS in adult participants with CAD. Studies were excluded if participants had chronic or acute inflammatory conditions, renal failure, liver failure, or had undergone major operations before being enrolled. RESULTS: Among 2338 studies reviewed, 15 RCTs met the inclusion criteria. Out of the 15 RCTs, nine reported on supplemental antioxidants (i.e., L-carnitine and melatonin), and two reported on dietary antioxidants (Khorasan wheat diet and wine) that were effective at lowering OS (P < 0.05). One study found Brazil nuts (dietary antioxidants) ineffective at lowering OS. The three remaining RTCs reported that intravenously administered antioxidants, including alpha-lipoic acid, vitamin C, or N-acetylcysteine, significantly lowered OS. CONCLUSIONS: The reviewed RTCs provide evidence that antioxidants may lower OS in patients with CAD. The utility of this conclusion is limited by the studies' methodologies that examine various antioxidants and measure OS through a variety of biomarkers. This heterogeneity in methodologies between studies indicates that further research is needed with standardized interventions and outcomes. Copyright © 2025 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. DOI: 10.1016/j.clnesp.2025.08.037 PMID: 40914496 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare no conflict of interest.
6. Medicine (Baltimore). 2025 Aug 22;104(34):e43976. doi: 10.1097/MD.0000000000043976. Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial. Liu X(1)(2), Chen B(2)(3), Jin Y(2), Zhong F(2), Zhang Y(2), Li Y(4), Zhang Y(5), Cui R(5), Wu B(6), Li C(7), Xu S(8), Chen X(1)(2)(9). Author information: (1)The First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, China. (2)College of Exercise and Health, Shenyang Sport University, Shenyang, China. (3)Department of Exercise Physiology, Beijing Sport University, Beijing, China. (4)Department of Gerontology, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, China. (5)Department of Rehabilitation Medicine, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, China. (6)Department of Laboratory, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, China. (7)Department of Nutrition, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, China. (8)Department of Ultrasound, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, China. (9)Department of Neurology, Jin Qiu Hospital of Liaoning Province, Geriatric Hospital of Liaoning Province, Shenyang, China. BACKGROUND: Resistance training (RT) is a fundamental sarcopenia treatment, but its efficacy may be enhanced by nutritional strategies. This study investigated whether combining RT with vitamins C and E supplementation yields additive benefits in sarcopenia patients. METHODS: Sixty older women with sarcopenia (60-75 years) were randomized to an antioxidant supplementation group (AS; 1000 mg/d vitamin C and 335 mg/d vitamin E) or a placebo group (PLA) following the same elastic-band RT program. Muscle mass, muscle strength, physical performance, oxidative stress-related indices (reduced glutathione [GSH] and oxidized glutathione [GSSG], GSH/GSSG ratio, malondialdehyde, and protein carbonyl), and pro-inflammatory factors (interleukin-6 [IL-6] and tumor necrosis factor-alpha) were evaluated at baseline and after the 12-week intervention. RESULTS: After 12 weeks, muscle mass, strength, and physical performance significantly increased (P < .05) in both the AS and PLA groups. However, the AS group had higher increases in arm lean mass (Δ = 0.96 vs 0.59 kg; P = .003, d = 0.74), skeletal muscle mass index (Δ = 0.71 vs 0.42 kg/m²; P = .004, d = 0.71), handgrip strength (Δ = 3.66 vs 1.16 kg; P = .047, d = 0.51), and knee extension strength (Δ = 2.28 vs 1.02 kg; P < .001, d = 0.89) than the PLA group. There were no differences in physical performance between the RT conditions over time. Regarding blood parameters, the AS group had increased GSH (P < .001, d = 1.52) and GSH/GSSG ratio (P < .001, d = 1.52), and reduced GSSG (P < .001, d = 0.96) and malondialdehyde (P < .001, d = 1.65) compared to the PLA group. The serum levels of IL-6 and tumor necrosis factor-alpha significantly decreased in the PLA and AS groups, but IL-6 was lower in the AS group than in the PLA group (P < .001, d = 1.16). CONCLUSION: Vitamins C and E supplementation combined with RT for 12 weeks resulted in superior adaptations in muscle mass and strength compared with RT with placebo, and the underlying mechanism could be related to the alleviation of oxidative stress and inflammation. Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc. DOI: 10.1097/MD.0000000000043976 PMCID: PMC12384908 PMID: 40859523 [Indexed for MEDLINE] Conflict of interest statement: The authors have no conflicts of interest to disclose.
7. Front Immunol. 2025 Jul 16;16:1547888. doi: 10.3389/fimmu.2025.1547888. eCollection 2025. The effect of co-administration of vitamin E and C supplements on plasma oxidative stress biomarkers and antioxidant capacity: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials with meta-regression. Moabedi M(1)(2), Milajerdi A(3). Author information: (1)Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. (2)Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. (3)Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. BACKGROUND: There is no conclusion on the effect of vitamins E and C on plasma biomarkers of oxidative stress and antioxidant status. We conducted this meta-analysis to gain a clearer view of this area. METHODS: We performed a systematic search in online databases using the relevant keyword combination. Randomized controlled trials that investigated the effect of vitamins E and C simultaneously, compared with control, on oxidative stress and antioxidant status biomarkers were included in the analyses. RESULTS: A total of 17 trials were included in the meta-analysis, building a total sample size of 965. The dosage of vitamin E and C supplements varied from 54 to 536 and 250 to 1000 mg/d, respectively, across included studies. We found significant results for MDA [WMD: -0.38, 95% CI: -0.48, -0.28 µg/L, P <0.001], LP [WMD: -1.01, 95% CI: -1.49, -0.54 µg/L, P <0.001], TAC [WMD: 0.09, 95% CI: 0.05, 0.13 mmol/L, P <0.001], and GPx [WMD: 1251.74, 95% CI: 258.92, 2244.56 U/L, P = 0.013], but not for SOD [WMD: 16.69, 95% CI: -29.40, 62.78 U/L, P = 0.278]. Regarding subgroup analysis, only studies on unhealthy participants showed a significant effect on MDA [WMD: -1.62, 95% CI: -2.08, -1.15 µg/L, P <0.001] and TAC [WMD: 0.08, 95% CI: 0.03, 0.14 mmol/L, P <0.001], unlike LP, where significance was only observed in healthy adults [WMD: -0.41, 95% CI: -0.45, -0.37 µg/L, P <0.001]. Moreover, only studies in which a placebo was administered, supplementation of vitamins showed significant effects on MDA [WMD: -0.47, 95% CI: -0.58, -0.35 µg/L, P <0.001], LP [WMD: -1.28, 95% CI: -1.85, -0.72 µg/L, P <0.001], and TAC [WMD: 0.10, 95% CI: 0.05, 0.15 mmol/L, P <0.001]. CONCLUSION: Our review and analyses revealed that a combination of vitamin C and E has a beneficial effect on oxidative stress biomarkers and antioxidant status. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024590197, identifier CRD42024590197. Copyright © 2025 Moabedi and Milajerdi. DOI: 10.3389/fimmu.2025.1547888 PMCID: PMC12307169 PMID: 40740780 [Indexed for MEDLINE] Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
8. PLoS One. 2025 Jul 9;20(7):e0327628. doi: 10.1371/journal.pone.0327628. eCollection 2025. The effect of vitamin supplementation on neurodevelopmental and clinical outcomes in very low birth weight and very preterm infants: A systematic review and meta-analysis. Bronnert A(1), Bloomfield PM(1), Páramo LD(1), Lin L(1), Bloomfield FH(1), Cormack BE(2). Author information: (1)The Liggins Institute, Auckland, New Zealand. (2)Starship Child Health, Auckland, New Zealand. BACKGROUND: Nutrition is vital for preterm infant development. Vitamins play key roles as cofactors and gene regulators for metabolic and immune functions and are common added components of preterm infant nutrition. However, information on how vitamins impact in-hospital and neurodevelopmental outcomes is sparse. We aimed to determine the effect of fat- and water-soluble vitamin supplementation on clinical outcomes during neonatal care and later neurodevelopment of very preterm (≤32 weeks' gestation) and very low birth weight (≤1500 g) infants. METHODS AND FINDINGS: 4 databases and 3 clinical trial registries were systematically searched for randomised controlled trials (RCTs). Two reviewers independently extracted data and assessed quality using the Cochrane Risk of Bias tool. Meta-analyses were conducted using a random-effect model for each vitamin subgroup. Data are presented as risk ratios [95% confidence intervals]. Of 4074 references identified, 43 studies were included in the review. Only 2 reported neurodevelopment at 2 years, and only 4 were studies of water-soluble vitamins (vitamin C, 3 studies; B12 and folate, 1 study). Survival free from neurodisability was not affected by supplementation of vitamin A (0.89 [0.74-1.08], n = 538, very low certainty of evidence) or vitamin D (0.76 [0.46-1.27], n = 78, very low certainty of evidence). The incidence of bronchopulmonary dysplasia was decreased by vitamins D (0.58 [0.41-0.83]) and C (0.59 [0.37-0.93]), very low certainty of evidence), retinopathy of prematurity was decreased by vitamins A (0.77 [0.61-0.98]) and E (0.10 [0.01-0.80]), very low to low certainty of evidence) and intraventricular haemorrhage was decreased by vitamin E (0.70 [0.52-0.92], moderate certainty of evidence). Culture-proven sepsis was decreased by vitamin A (0.88 [0.77-0.99], moderate certainty of evidence). CONCLUSIONS: There are few and inconclusive data on the effect of vitamin supplementation in preterm infants on later neurodevelopment. Evidence for shorter-term outcomes is mostly of low certainty. Together with substantial heterogeneity in trial design, it therefore is difficult to recommend a specific supplementation regimen. Registry and Registry Number: This systematic review was prospectively registered on PROSPERO, ID CRD42023418552, available from https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023418552. Copyright: © 2025 Bronnert et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. DOI: 10.1371/journal.pone.0327628 PMCID: PMC12240376 PMID: 40632831 [Indexed for MEDLINE] Conflict of interest statement: I have read the journal's policy and the authors of this manuscript have the following competing interests: BEC reports a relationship with Nestle Nutrition Institute and Nutricia Danone Australia Pty that includes board membership and speaking and lecture fees. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
9. Rev Bras Ginecol Obstet. 2025 Mar 17;47:e-rbgo1. doi: 10.61622/rbgo/2025rbgo1. eCollection 2025. Efficacy of vitamin C supplementation during pregnancy in the prevention of preterm birth: a systematic review and meta-analysis. Pereira AGA(1), Molino GOG(2), Santos ACFF(3), Dias MMF(4), Pimenta NDS(5), da Silva PHCM(6). Author information: (1)Universidade Estadual Paulista "Júlio de Mesquita Filho" São PauloSP Brazil Universidade Estadual Paulista "Júlio de Mesquita Filho", São Paulo, SP, Brazil. (2)Universidade Federal de Ciências da Saúde de Porto Alegre Porto AlegreRS Brazil Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil. (3)Universidade Cidade de São Paulo São PauloSP Brazil Universidade Cidade de São Paulo, São Paulo, SP, Brazil. (4)Universidade Federal de Campina Grande Campina GrandePB Brazil Universidade Federal de Campina Grande, Campina Grande, PB, Brazil. (5)Universidade Federal do Estado do Rio de Janeiro Rio de JaneiroRJ Brazil Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. (6)Universidade Federal de Goiás GoiâniaGO Brazil Universidade Federal de Goiás, Goiânia, GO, Brazil. OBJECTIVE: Preterm birth is a leading global cause of neonatal mortality and morbidity, with oxidative stress playing a role in its pathogenesis. Vitamin C, a powerful antioxidant, may help reduce this risk. This study assessed the effectiveness of vitamin C supplementation, both alone and with vitamin E, in preventing preterm birth compared to a placebo. DATA SOURCE: Databases were systematically searched in PubMed, Cochrane and Embase in December 2023 and updated in May 2024. STUDY SELECTION: Included RCTs evaluated vitamin C's effect on preterm birth and related neonatal outcomes. DATA COLLECT: Statistical analyses used a random-effects model for pooled risk ratios (RR) and 95% confidence intervals (CI). Heterogeneity was assessed with the I² statistic. DATA SYNTHESIS: Seventeen RCTs (21,567 patients) were analyzed. Vitamin C supplementation showed no significant difference compared to placebo for preterm birth (RR 1.04; 95% CI 0.96, 1.14). No significant differences were observed for neonatal death (RR 0.77; 95% CI 0.55, 1.08), NICU admission (RR 1.03; 95% CI 0.95, 1.13), preterm PROM (RR 1.04; 95% CI 0.63, 1.71), or birth weight (MD 52.41; 95% CI -19.65, 124.47). A slight decrease in gestational age was observed (MD 0.26; 95% CI -0.02, 0.55). CONCLUSION: Vitamin C supplementation alone or in combination with vitamin E does not significantly prevent preterm birth or improve related neonatal outcomes. DOI: 10.61622/rbgo/2025rbgo1 PMCID: PMC12204115 PMID: 40584396 [Indexed for MEDLINE] Conflict of interest statement: Conflicts to interest: none to declare.
10. Int J Mol Sci. 2025 May 29;26(11):5209. doi: 10.3390/ijms26115209. A Plant-Based Dietary Supplement Exhibits Significant Effects on Markers of Oxidative Stress, Inflammation, and Immune Response in Subjects Recovering from Respiratory Viral Infection: A Randomized, Double-Blind Clinical Study Using Vitamin C as a Positive Control. Fink B(1), Hunter JM(2), Pietrzkowski Z(3), Fink R(1), Brunssen C(4), Morawietz H(4), Nemzer B(2). Author information: (1)Noxygen Science Transfer & Diagnostics GmbH, 79215 Elzach, Germany. (2)VDF FutureCeuticals, Inc., Momence, IL 60954, USA. (3)VDF FutureCeuticals, Inc. Irvine, CA 92606, USA. (4)Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Medical Faculty Carl Gustav Carus and University Hospital Carl Gustav Carus Dresden, TUD University of Technology Dresden, 01307 Dresden, Germany. Respiratory viruses continue to present serious health challenges to human wellness. Growing evidence suggests that the more severe and damaging effects and symptoms of influenza, rhinovirus (RV), respiratory syncytial virus (RSV), and COVID-19 may primarily result from their common ability to disorganize the body's healthy immune response. The simultaneous over-stimulation of several reactive oxygen species (ROS) pathways and concurrent suppression of bioavailable Nitic Oxide (NO) contribute to an immune disbalance that can lead to cellular oxidative distress and an excessive inflammatory response. This study evaluated the real-time, acute ability of a single, orally administered 50 mg encapsulated dose of a plant-based dietary supplement ("PB-Blend"), compared to 1000 mg of Vitamin C as a positive control, to modulate multiple ROS associated with a dampened immune response, as well as NO and other markers of inflammation, in a cohort recovering from a moderate course of COVID-19. This randomized, double-blind study was performed on 28 individuals 18-24 days after a moderate COVID-19 infection. Participants were orally supplemented with a single encapsulated dose of either 50 mg of PB-Blend or 1000 mg Vitamin C as a positive control. Changes in the levels of bioavailable NO (measured as circulating NOHb) were assessed, as well as the ex vivo cellular formation of mitochondrial, NOX2-, iNOS-, and TNFα-dependent ROS. All parameters were measured in real time before ingestion (baseline), and then at 30, 60, 120, and 180 min after administration. ROS were measured using a portable electron paramagnetic resonance (EPR) spectrometer. Inflammatory, immunity (hsCRP and TNFα plasma levels), interleukin (IL1, IL6, IL8, and IL10), cytokine (IFNγ, TNFα, and NF-κB), and immunoglobulin (IgA, IgM, IgG, and IgE) profiles were also followed. In addition to laboratory and cell function investigations, we performed clinical cardio ergometry, blood O2 saturation, and respirometry examinations. As hypothesized, the collected baseline data from this study group confirmed that mitochondrial, NOX2, and iNOS enzymatic systems were strongly involved in the generation of ROS at 18-24 days following a positive COVID-19 PCR test. Acute single-dose supplementation of 50 mg PB-Blend had a multifunctional impact on ROS and significantly inhibited the following: (a.) mitochondrial ROS levels by up to 56%; (b.) iNOS by up to 60%; and (c.) NOX2-dependent ROS generation by up to 49%. Moreover, 1000 mg Vitamin C supplementation exhibited narrower ROS-mitigating activity by solely inhibiting NOX2-dependent ROS generation by 45%. Circulating NOHb levels were significantly increased after PB-Blend administration (33%), but not after Vitamin C administration. PB-Blend and Vitamin C exhibited similar potential to reduce ex vivo high dose TNFα (200 ng/mL)-induced H2O2 formation. These results suggest that 50 mg of PB-Blend has the potential to modulate disbalanced mitochondria, iNOS, and NOX2 enzymatic systems that can be engendered during respiratory viral infection and subsequent recovery. Moreover, PB-Blend, but not Vitamin C, showed potential to upregulate bioavailable NO, which is known to decline under these conditions. Based upon these observations, PB-Blend could be considered an alternative to, or to be used in tandem with Vitamin C in applications that promote immune support and recovery during seasons of heightened respiratory viral risk (e.g., "flu season"). DOI: 10.3390/ijms26115209 PMCID: PMC12153994 PMID: 40508019 [Indexed for MEDLINE] Conflict of interest statement: B.N., Z.P., and J.M.H. are employees and receive compensation from VDF FutureCeuticals, Inc. B.F. and R.F. are employees and receive compensation from Noxygen Science Transfer & Diagnostics GmbH. The remaining authors H.M. and C.B. declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from VDF FutureCeuticals, Inc., Momence, IL USA. Other than funding, the funder had no involvement or influence beyond what has been declared by the authors herein.
11. J Nutr Biochem. 2025 Jul;141:109906. doi: 10.1016/j.jnutbio.2025.109906. Epub 2025 Mar 20. Berry supplementation in healthy volunteers modulates gut microbiota, increases fecal polyphenol metabolites and reduces viability of colon cancer cells exposed to fecal water- a randomized controlled trial. Onali T(1), Slabá H(1), Jian C(2), Koivumäki T(1), Päivärinta E(1), Marttinen M(1), Määttänen M(1), Salonen A(2), Pajari AM(3). Author information: (1)Department of Food and Nutrition, University of Helsinki, Finland. (2)Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Finland. (3)Department of Food and Nutrition, University of Helsinki, Finland. Electronic address: anne-maria.pajari@helsinki.fi. Diets high in red and processed meat and low in plant-based foods are associated with an increased risk of colorectal cancer. We investigated whether berry supplementation can impact gut metabolism to counteract the presumably cancer promoting luminal environment sustained by high red and processed meat consumption. Altogether 43 healthy adults were randomized either into Meat group (150 g/d red and processed pork meat) or Meat & Berries group (150 g/d red and processed meat and 200 g/d of mixed berries). Fecal samples and 3-d food records were collected at baseline and at the end of the four-week intervention. Intakes of vitamin C, vitamin E, manganese, insoluble fiber, and the polyphenols available in the database were significantly higher in the Meat & Berries than Meat group. While between-group comparisons found no significant differences in the gut microbiota, the within-group analyses showed that the relative abundances of beneficial Roseburia and Faecalibacterium were decreased and an unclassified group of Peptostreptococcaceae increased significantly in the Meat group. In comparison to the Meat group, berry consumption resulted in higher fecal concentrations of p-coumaric and protocatechuic acids and lower viability of fecal water (FW) -treated CV1-P fibroblastoma and human colon adenocarcinoma HCA-7 and Caco-2 cells (P<.05 with 30% FW). Berry consumption provided protective nutrients and mitigated potentially unfavourable gut microbiota changes seen in the Meat group, increased fecal polyphenol metabolites, and reduced viability of FW-treated colon adenocarcinoma cells, collectively suggesting that berries may protect against colorectal cancer development. Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved. DOI: 10.1016/j.jnutbio.2025.109906 PMID: 40120775 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest None.
12. Am J Perinatol. 2025 Aug;42(11):1469-1476. doi: 10.1055/a-2509-1828. Epub 2025 Mar 6. The Effect of Maternal Antioxidant Vitamin Supplementation on Maternal and Cord Blood Adiponectin Concentrations. Pippen JL(1), McGee P(2), Roberts JM(3), Myatt L(4), Varner MW(5), Tita ATN(6), Wapner RJ(7), Thorp JM Jr(8), Mercer BM(9), Plunkett BA(10), Blackwell SC(11), Sciscione A(12), Saade GR(13); Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network. Author information: (1)Departments of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio. (2)The George Washington University Biostatistics Center, Washington, District of Columbia. (3)University of Pittsburgh, Pittsburgh, Pennsylvania. (4)University of Cincinnati, Cincinnati, Ohio. (5)University of Utah Health Sciences Center, Salt Lake City, Utah. (6)University of Alabama at Birmingham, Birmingham, Alabama. (7)Columbia University, New York, New York. (8)University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. (9)Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio. (10)Northwestern University, Chicago, Illinois. (11)University of Texas Health Science Center at Houston, Houston, Texas. (12)Drexel University, Philadelphia, Pennsylvania. (13)University of Texas Medical Branch, Galveston, Texas. Adiponectin is a hormone that modulates glucose regulation and fatty acid oxidation. Low adiponectin concentration has been associated with increased insulin resistance. Studies show a beneficial effect of vitamin E supplementation on insulin sensitivity. We aimed to investigate the association of prenatal antioxidant supplementation with increased adiponectin concentrations in pregnant participants and their newborn infants.Secondary analysis of a randomized control trial of prenatal vitamin C and E supplementation to prevent preeclampsia in low-risk nulliparous participants. Plasma of participants at time of randomization (9-16 weeks gestation) and delivery, and neonatal cord blood were analyzed by specific enzyme-linked immunosorbent assay for adiponectin concentration. Multivariable analysis was adjusted for confounders.A total of 198 (98 vitamin, 100 placebo) maternal-neonatal dyad samples were analyzed. Maternal and neonatal characteristics were similar between the vitamin and placebo groups, with the exception of race/ethnicity, with Whites more common in the placebo group (80 vs. 66.3%, p = 0.02). In bivariable analyses, adiponectin concentrations at delivery were higher in the vitamin group compared with the placebo group (29.4 vs. 27.5 µg/mL, p = 0.04), whereas cord blood adiponectin concentrations were similar (26.6 . vs. 27.4 µg/mL, p = 0.47) between the two groups. There was a significant interaction between treatment group and maternal baseline adiponectin level on the adiponectin concentrations at delivery (p = 0.04) and cord blood adiponectin (p < 0.05). For participants whose baseline adiponectin concentrations were in the highest tertile, vitamin supplementation was associated with higher adiponectin concentrations at delivery. However, for participants whose baseline adiponectin concentration were in the lowest tertile, vitamin supplementation was associated with lower cord blood adiponectin concentrations.For participants with high baseline adiponectin concentration, vitamin C and E supplementation is associated with higher adiponectin concentration at delivery. Conversely, vitamin supplementation is associated with lower cord adiponectin concentration among participants with low baseline adiponectin concentration. · Vitamin E is an antioxidant with metabolic properties.. · Adiponectin is a cytokine with metabolic properties.. · Vitamin E is associated with higher pregnancy adiponectin.. · Vitamin E is associated with lower neonatal adiponectin.. · Vitamin E correlated with positive pregnancy and neonatal adiponectin trends.. Thieme. All rights reserved. DOI: 10.1055/a-2509-1828 PMCID: PMC12286745 PMID: 40049594 [Indexed for MEDLINE] Conflict of interest statement: None declared.
13. Nutr Clin Pract. 2024 Oct;39(5):1119-1149. doi: 10.1002/ncp.11195. Epub 2024 Aug 9. New randomized controlled trials on micronutrients in critical care nutrition: A narrative review. Halim Z(1), Huang Y(1), Lee ZY(2)(3), Lew CCH(4)(5). Author information: (1)Department of Dietetics, Changi General Hospital, Singapore, Singapore. (2)Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. (3)Department of Cardiac Anesthesiology & Intensive Care Medicine, Charité Berlin, Germany. (4)Department of Dietetics & Nutrition, Ng Teng Fong General Hospital, Singapore, Singapore. (5)Faculty of Health and Social Sciences, Singapore Institute of Technology, Singapore, Singapore. There has been increasing interest in the role of micronutrient supplementation in critical care. This narrative review summarizes the recent studies on micronutrients in critically ill patients. We searched two databases for primary randomized controlled trials that investigated the effects of micronutrient supplementation in patients with critical illness published from January 2021 to August 2023. Personal files, reference lists of included studies, and previous reviews were also screened. Twelve studies reported on vitamin C, four studies on vitamin D, three studies on thiamin, two studies on multivitamins, and one study on cobalamin. The therapeutic effects of vitamin C appear mixed, although vitamin C monotherapy appears more promising than vitamin C combination therapy. Intramuscular administration of vitamin D appeared to lower mortality, mechanical ventilation duration, and intensive care unit stay, whereas enteral administration showed limited clinical benefits. Intravenous thiamin was not associated with improved outcomes in patients with septic shock or hypophosphatemia. Preliminary evidence suggests reduced vasopressor dose with cobalamin. Decreased disease severity and hospital stay in patients with COVID-19 with vitamins A-E requires further investigation, whereas providing solely B-group vitamins did not demonstrate therapeutic effects. It is currently premature to endorse the provision of high-dose micronutrients in critical illness to improve clinical outcomes. This review may help to inform the design of future trials that will help better elucidate the optimal dosage and form of micronutrients, methods of administration, and subgroups of patients with critical illness who may most benefit. © 2024 American Society for Parenteral and Enteral Nutrition. DOI: 10.1002/ncp.11195 PMID: 39119820 [Indexed for MEDLINE]
14. PLoS One. 2024 Jun 13;19(6):e0304402. doi: 10.1371/journal.pone.0304402. eCollection 2024. Dietary supplementations to mitigate the cardiopulmonary effects of air pollution toxicity: A systematic review of clinical trials. Ilaghi M(1), Kafi F(2), Shafiei M(3), Zangiabadian M(4), Nasiri MJ(5). Author information: (1)Institute of Neuropharmacology, Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran. (2)School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. (3)Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran. (4)Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. (5)Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. BACKGROUND: There is a consistent association between exposure to air pollution and elevated rates of cardiopulmonary illnesses. As public health activities emphasize the paramount need to reduce exposure, it is crucial to examine strategies like the antioxidant diet that could potentially protect individuals who are unavoidably exposed. METHODS: A systematic search was performed in PubMed/Medline, EMBASE, CENTRAL, and ClinicalTrials.gov up to March 31, 2023, for clinical trials assessing dietary supplements against cardiovascular (blood pressure, heart rate, heart rate variability, brachial artery diameter, flow-mediated dilation, and lipid profile) or pulmonary outcomes (pulmonary function and airway inflammation) attributed to air pollution exposure. RESULTS: After reviewing 4681 records, 18 studies were included. There were contradictory findings on the effects of fish oil and olive oil supplementations on cardiovascular outcomes. Although with limited evidence, fish oil offered protection against pulmonary dysfunction induced by pollutants. Most studies on vitamin C did not find protective cardiovascular effects; however, the combination of vitamin C and E offered protective effects against pulmonary dysfunction but showed conflicting results for cardiovascular outcomes. Other supplements like sulforaphane, L-arginine, n-acetylcysteine, and B vitamins showed potential beneficial effects but need further research due to the limited number of existing trials. CONCLUSIONS: Although more research is needed to determine the efficacy and optimal dose of anti-inflammatory and antioxidant dietary supplements against air pollution toxicity, this low-cost preventative strategy has the potential to offer protection against outcomes of air pollution exposure. Copyright: © 2024 Ilaghi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. DOI: 10.1371/journal.pone.0304402 PMCID: PMC11175466 PMID: 38870164 [Indexed for MEDLINE] Conflict of interest statement: The authors have declared that no competing interests exist.
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