밀 배아유
Wheat Germ Oil
📚 관련 논문 (16편)
1. Nutrients. 2022 Mar 27;14(7):1397. doi: 10.3390/nu14071397. Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study. De Cosmi V(1), Mazzocchi A(1), D'Oria V(2),
2. Eur J Nutr. 2022 Aug;61(5):2571-2583. doi: 10.1007/s00394-022-02827-w. Epub 2022 Feb 27. UVB-exposed wheat germ oil increases serum 25-hydroxyvitamin D(2) without improving overall vitamin D status: a randomized controlled trial. Bailer AC(1)(2), Philipp S(1), Staudt S(2)(3), Weidauer T(2)(3)
3. Geriatrics. 2001 Aug;56(8):44-7. Alternative medicine. Achieving balance between herbal remedies and medical therapy. Rhodes-Kropf J(1), Lantz MS; American Association for Geriatric Psychiatry. Author information: (1)Brookdale Department of Geriatrics and Adult Development, Mount Sinai School
4. Braz J Biol. 2021 Sep 20;83:e249209. doi: 10.1590/1519-6984.249209. eCollection 2021. The use of babosa (Aloe vera) in treating burns: a literature review. Zago LR(1), Prado K(1), Benedito VL(1), Pereira MM(1). Author information: (1)Centro Universitário São Camilo, Curso de Medicina, São Pau
1. Nutrients. 2021 Feb 9;13(2):578. doi: 10.3390/nu13020578. Effect of Omega-3 Supplementation in Pregnant Women with Obesity on Newborn Body Composition, Growth and Length of Gestation: A Randomized Controlled Pilot Study. Monthé-Drèze C(1)(2), Sen S(1)(2), Hauguel-de Mouzon S(3), Catalano PM(4). Author information: (1)Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. (2)School of Medicine, Harvard University, Boston, MA 02115, USA. (3)Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH 44106, USA. (4)Mother Infant Research Institute, Tufts Medical Center, Boston, MA 02111, USA. Maternal obesity, a state of chronic low-grade metabolic inflammation, is a growing health burden associated with offspring adiposity, abnormal fetal growth and prematurity, which are all linked to adverse offspring cardiometabolic health. Higher intake of anti-inflammatory omega-3 (n-3) polyunsaturated fatty acids (PUFA) in pregnancy has been associated with lower adiposity, higher birthweight and longer gestation. However, the effects of n-3 supplementation specifically in pregnant women with overweight and obesity (OWOB) have not been explored. We conducted a pilot double-blind randomized controlled trial of 72 pregnant women with first trimester body mass index (BMI) ≥ 25 kg/m2 to explore preliminary efficacy of n-3 supplementation. Participants were randomized to daily DHA plus EPA (2 g/d) or placebo (wheat germ oil) from 10-16 weeks gestation to delivery. Neonatal body composition, fetal growth and length of gestation were assessed. For the 48 dyads with outcome data, median (IQR) maternal BMI was 30.2 (28.2, 35.4) kg/m2. In sex-adjusted analyses, n-3 supplementation was associated with higher neonatal fat-free mass (β: 218 g; 95% CI 49, 387) but not with % body fat or fat mass. Birthweight for gestational age z-score (-0.17 ± 0.67 vs. -0.61 ± 0.61 SD unit, p = 0.02) was higher, and gestation longer (40 (38.5, 40.1) vs. 39 (38, 39.4) weeks, p = 0.02), in the treatment vs. placebo group. Supplementation with n-3 PUFA in women with OWOB led to higher lean mass accrual at birth as well as improved fetal growth and longer gestation. Larger well-powered trials of n-3 PUFA supplementation specifically in pregnant women with OWOB should be conducted to confirm these findings and explore the long-term impact on offspring obesity and cardiometabolic health. DOI: 10.3390/nu13020578 PMCID: PMC7916127 PMID: 33572368 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
2. Int J Vitam Nutr Res. 2021 Jan;91(1-2):56-62. doi: 10.1024/0300-9831/a000604. Epub 2019 Aug 21. Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients. Zakaria H(1), Mostafa TM(2), El-Azab GA(2), Ah Sayed-Ahmed N(3). Author information: (1)Department of Pharmacy, Mansoura Fever Hospital, Mansoura, Egypt. (2)Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta, Egypt. (3)Department of Internal Medicine, Faculty of Medicine, Mansoura, Egypt. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients. DOI: 10.1024/0300-9831/a000604 PMID: 31433269 [Indexed for MEDLINE]
3. Minerva Med. 2018 Dec;109(6):418-428. doi: 10.23736/S0026-4806.18.05845-7. Epub 2018 Sep 13. Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD: a randomized clinical study. Kobyliak N(1), Abenavoli L(2), Falalyeyeva T(3), Mykhalchyshyn G(4), Boccuto L(5), Kononenko L(4), Kyriienko D(4)(6), Komisarenko I(4), Dynnyk O(7). Author information: (1)Department of Endocrinology, Bogomolets National Medical University, Kyiv, Ukraine - nazariikobyliak@gmail.com. (2)Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy. (3)Taras Shevchenko National University of Kyiv, Kyiv, Ukraine. (4)Department of Endocrinology, Bogomolets National Medical University, Kyiv, Ukraine. (5)Research Department, Greenwood Genetic Center, Greenwood School of Health Research, Clemson University, Clemson, SC, USA. (6)Kyiv City Clinical Endocrinology Center, Kyiv, Ukraine. (7)Bogomolets Institute of Physiology of the Ukrainian National Academy of Science, Kyiv, Ukraine. BACKGROUND: The manipulation of gut microbiota via administration of probiotics has been proposed as a potential strategy for the treatment of non-alcoholic fatty liver disease (NAFLD). Hence, we performed a double-blind single center randomized placebo-controlled trial (RCT) to evaluate the efficacy of coadministration of probiotics with omega-3 vs. placebo in type-2 diabetic patients with NAFLD. METHODS: A total of 48 patients met the criteria for inclusion. They were randomly assigned to receive "Symbiter Omega" combination of probiotic biomass supplemented with flax and wheat germ oil (250 mg of each, concentration of omega-3 fatty acids 1-5%) or placebo for 8-weeks. The primary main outcomes were the change in fatty liver index (FLI) and liver stiffness (LS) measured by Shear Wave Elastography (SWE). Secondary outcomes were the changes in transaminases level, serum lipids and cytokines levels. RESULTS: In probiotic-omega group, FLI significantly decreased from 83.53±2.60 to 76.26±2.96 (P<0.001) while no significant changes were observed in the placebo group (82.86±2.45 to 81.09±2.84; P=0.156). Changes of LS in both groups were insignificant. Analysis of secondary outcomes showed that the coadministration of probiotics with omega-3 lead to significant reduction of serum gamma-glutamyl transpeptidase, triglycerides, and total cholesterol. Chronic systemic inflammatory markers after intervention decrease significantly only in Symbiter Omega group: IL-1β (P=0.029), TNF-α (P<0.001), IL-8 (P=0.029), IL-6 (P=0.003), and INF-γ (P=0.016). CONCLUSIONS: Coadministration of a live multi-strain probiotic mixture with omega-3 fatty acids once daily for 8 weeks to patients with NAFLD can reduce liver fat, improve serum lipids, metabolic profile, and reduce chronic systemic inflammatory state. DOI: 10.23736/S0026-4806.18.05845-7 PMID: 30221912 [Indexed for MEDLINE]
4. Int Urol Nephrol. 2017 Oct;49(10):1851-1858. doi: 10.1007/s11255-017-1643-6. Epub 2017 Jun 30. The impact of fish oil and wheat germ oil combination on mineral-bone and inflammatory markers in maintenance hemodialysis patients: a randomized, double-blind, placebo-controlled clinical trial. Zakaria H(1), Mostafa TM(2), El-Azab GA(2), Abd El Wahab AM(3), Elshahawy H(4), Sayed-Ahmed NA(3). Author information: (1)Department of Pharmacy, Mansoura Fever Hospital, Mansoura, Egypt. dr.hadeer_2013@yahoo.com. (2)Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta, Egypt. (3)Department of Internal Medicine, Faculty of Medicine, Mansoura, Egypt. (4)Department of Clinical Pathology, Faculty of Medicine, Mansoura, Egypt. PURPOSE: This study aimed to examine the impact of combined supplementation of fish oil (FO) with antioxidants like wheat germ oil (WGO) on mineral-bone and inflammatory markers in maintenance HD patients. METHODS: This randomized, double-blind, placebo-controlled trial involved 46 HD patients who were randomly assigned into two groups to receive daily 3000 mg of FO [1053 mg omega-3 fatty acids (ω-3 FAs)] plus 300 mg of WGO [0.765 mg vitamin E] or placebo for 4 months. Blood concentrations of hemoglobin (Hgb), white blood cells, mineral-bone parameters including serum calcium (Ca), phosphorus, calcium-phosphorus product, parathyroid hormone, alkaline phosphatase, and osteoprotegerin and serum concentrations of inflammatory markers including high-sensitivity C-reactive protein, ferritin, and uric acid were measured before and after the intervention. RESULTS: Eighty-seven percentage of patients in each group completed the study. The mean serum Ca levels increased significantly in the supplemented group at the end of study (p = 0.0016), and this increment was also significant as compared to placebo group (p = 0.0418). No significant alterations were observed in the other measured parameters within each group during the study (as p values were >0.05). CONCLUSION: FO plus WGO supplementation showed beneficial effect on serum Ca levels of HD patients without any statistically significant effect on other mineral-bone and inflammatory markers. Further investigations are required to confirm it. DOI: 10.1007/s11255-017-1643-6 PMID: 28667579 [Indexed for MEDLINE]
5. Int J Food Sci Nutr. 2014 May;65(3):375-9. doi: 10.3109/09637486.2013.858239. Epub 2013 Nov 14. Blood lipids profile in hyperlipidemic children undergoing different dietary long chain polyunsaturated supplementations: a preliminary clinical trial. Verduci E(1), Agostoni C, Radaelli G, Banderali G, Riva E, Giovannini M. Author information: (1)Department of Pediatrics, San Paolo Hospital, University of Milan , Milan , Italy . The aim of this preliminary study was to explore the effect size of different dietary long chain polyunsaturated supplementations on blood lipid profile in children with primary hyperlipidemia. Thirty-six children (8-13 years) were recruited. After an 8-week stabilization period on the Step I diet, they were randomized to additionally receive for a 16-week period one capsule (500 mg) daily of docosahexaenoic acid (DHA) alone or a DHA plus eicosapentaenoic acid (EPA) mixture (45.6% DHA; 41.6% EPA) or wheat germ oil (control). An effect size (as percentage change from baseline) of +8%, -12% and -16% for high-density lipoprotein cholesterol (HDL-C), total cholesterol/HDL-C ratio and triglycerides was observed in children supplemented with DHA, compared to +2%, -8% and -12%, respectively, in children supplemented with DHA plus EPA. This preliminary study suggests powered trials appear feasible and are warranted to evaluate efficacy of n-3 long-chain polyunsaturated fatty acid dietary supplementations on the blood lipid profile of children with primary hyperlipidemia. DOI: 10.3109/09637486.2013.858239 PMID: 24228803 [Indexed for MEDLINE]
6. Climacteric. 2011 Oct;14(5):558-64. doi: 10.3109/13697137.2011.563882. Epub 2011 May 5. Improvement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study. Gossell-Williams M(1), Hyde C, Hunter T, Simms-Stewart D, Fletcher H, McGrowder D, Walters CA. Author information: (1)Department of Basic Medical Sciences, University of the West Indies, Kingston, Jamaica. OBJECTIVE: Pumpkin seed oil is rich in phytoestrogens and animal studies suggest that there is some benefit to supplementation in low estrogen conditions. This study is the first to evaluate the benefit of pumpkin seed oil in postmenopausal women. METHODS: This pilot study was randomized, double-blinded and placebo-controlled. Study participants included 35 women who had undergone natural menopause or had iatrogenically entered the climacteric due to surgery for benign pathology. Wheat germ oil (placebo; n = 14) and pumpkin seed oil (n = 21) were administered to eligible participants over a 12-week period at a dose of 2 g per day. Serum lipids, fasting plasma glucose and blood pressure were measured and an 18-point questionnaire regarding menopausal symptoms was administered; the atherogenic index was also calculated. Differences between groups, as well as before and after the period of supplementation, were evaluated with Student's t-test, Wilcoxon matched-pair signed-ranked test and Mann-Whitney test, as appropriate (Stata version 10.1). RESULTS: Women receiving pumpkin seed oil showed a significant increase in high density lipoprotein cholesterol concentrations (0.92 ± 0.23 mmol/l vs. 1.07 ± 0.27 mmol/l; p = 0.029) and decrease in diastolic blood pressure (81.1 ± 7.94 mmHg vs. 75.67 ± 11.93 mmHg; p < 0.046). There was also a significant improvement in the menopausal symptom scores (18.1 ± 9.0 vs. 13.2 ± 6.7; p < 0.030), with a decrease in severity of hot flushes, less headaches and less joint pains being the main contributors. Women in the group receiving wheat germ oil reported being more depressed and having more unloved feeling. CONCLUSION: This pilot study showed pumpkin seed oil had some benefits for postmenopausal women and provided strong evidence to support further studies. DOI: 10.3109/13697137.2011.563882 PMID: 21545273 [Indexed for MEDLINE]
7. Spec Care Dentist. 2010 Nov-Dec;30(6):225-9. doi: 10.1111/j.1754-4505.2010.00158.x. Epub 2010 Oct 19. Effect of omega-3 and vitamin E supplementation on dry mouth in patients with Sjögren's syndrome. Singh M(1), Stark PC, Palmer CA, Gilbard JP, Papas AS. Author information: (1)Division of Oral Medicine and Dental Research, Tufts University School of Dental Medicine, Boston, Massachusetts, USA. periodok@yahoo.com To determine whether omega-3 (n-3) increases saliva production in patients with Sjögren's syndrome, 61 patients with Sjögren's received either wheat germ oil (n = 23) or n-3 supplement (TheraTears Nutrition®) (n = 38) in a prospective, randomized, double-masked trial. The outcomes assessed were salivary secretion and markers for oral inflammation. The differences between the n-3 group and wheat germ oil group were not statistically significant for either unstimulated (US) or stimulated (SS) salivary secretion (p= 0.38 and p= 0.346, respectively) nor for the number of sites with probing depth (PD) ≥ 4 mm (p= 0.834). In this pilot study, supplementation with n-3 was not found to be significantly better than wheat germ oil in stimulating saliva production in patients with Sjögren's syndrome. ©2010 Special Care Dentistry Association and Wiley Periodicals, Inc. DOI: 10.1111/j.1754-4505.2010.00158.x PMID: 21044101 [Indexed for MEDLINE]
8. Atherosclerosis. 1990 Oct;84(2-3):229-37. doi: 10.1016/0021-9150(90)90095-z. Fish oil produces an atherogenic lipid profile in hypertensive men. Hughes GS(1), Ringer TV, Watts KC, DeLoof MJ, Francom SF, Spillers CR. Author information: (1)Upjohn Company, Upjohn Research Clinics, Kalamazoo, MI 49007. The effects of fish oil supplements on plasma and platelet membrane lipids, lipoproteins, sex steroid hormones, glucose, insulin, platelet aggregation, and blood pressure in normal subjects (n = 13) and patients with essential hypertension (n = 13) were studied in this randomized, double-blind, placebo-controlled, two-way crossover study. Treatments consisted of 30 days of 5 g of n-3 fatty acids (ten 1-g capsules of fish oil daily) or placebo capsules (ten wheat germ oil capsules daily) with a one-month washout in between each crossover. Serum lipids and lipoproteins were measured before dosing and every two weeks during the study. Sex steroid hormones, glucose, insulin, and fatty acid composition in platelet membrane phospholipids were measured before dosing and at the end of each crossover. During treatment with fish oil, only the hypertensive had increases in total cholesterol (8%, p less than 0.026), LDL cholesterol (19%, p less than 0.006) and apolipoprotein B (18%, p less than 0.026). Serum androgens (total and free testosterone) were 30% lower in hypertensives than normotensives before any dosing, but were unchanged with placebo or fish oil capsules in either group. Plasma glucose, insulin, platelet aggregation, and the incorporation of n-3 fatty acids into platelet membrane phospholipid subfractions were similar in both normotensive and hypertensive men. Blood pressure was not affected by fish oil treatment in either group of men. These results provide evidence that fish oil may adversely affect serum lipids to yield an atherogenic lipid profile in hypertensive men. DOI: 10.1016/0021-9150(90)90095-z PMID: 2282101 [Indexed for MEDLINE]
9. Hinyokika Kiyo. 2008 Jun;54(6):435-45. [Assessment of clinical usefulness of Eviprostat for benign prostatic hyperplasia--comparison of Eviprostat tablet with a formulation containing two-times more active ingredients]. [Article in Japanese] Tamaki M(1), Nakashima M, Nishiyama R, Ikeda H, Hiura M, Kanaoka T, Nakano T, Hayashi T, Ogawa O. Author information: (1)Department of Urology, Japanese Red Cross Society Wakayama Medical Center. We compared the usefulness of Eviprostat tablet, a therapeutic agent for benign prostatic hyperplasia (BPH), and EVI-F tablet, a new formulation of Eviprostat containing two times more active ingredients (Chimaphila umbellata extract, Populus tremula extract, Pulsatilla pratensis extract, Equisetum arvense extract and purified wheat germ oil) and consequently designed to reduce the number of tablets per dose by half. In this study, patients with BPH were randomly assigned to either Eviprostat group (6 tabs/day) or EVI-F group (3 tabs/day) using the envelope method. The clinical efficacy of these two drugs were evaluated by the International Prostate Symptom Score (IPSS) and QOL score at the end of the treatment period, and their safety was evaluated by the incidence of side effects. Based on the clinical study guidelines for dysuria, the change in the IPSS total score and QOL score were comparable to the previously reported data for other treatment agents for BPH, and these indices showed gradual improvement with the treatment period. Both treatments were well tolerated. The clinical usefulness of the monotherapy with EVI-F tablet or Eviprostat tablet was reasonably demonstrated in this study. Furthermore, both treatments reduced nocturia, which has an impact on the QOL of patients with BPH. PMID: 18634442 [Indexed for MEDLINE]
10. Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2577-8. doi: 10.1161/01.ATV.0000242795.08322.fb. Alpha-linolenic acid-rich wheat germ oil decreases oxidative stress and CD40 ligand in patients with mild hypercholesterolemia. Alessandri C, Pignatelli P, Loffredo L, Lenti L, Del Ben M, Carnevale R, Perrone A, Ferro D, Angelico F, Violi F. DOI: 10.1161/01.ATV.0000242795.08322.fb PMID: 17053175 [Indexed for MEDLINE]
11. Am J Obstet Gynecol. 2002 Nov;187(5):1389-94. doi: 10.1067/mob.2002.127377a. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. Blommers J(1), de Lange-De Klerk ES, Kuik DJ, Bezemer PD, Meijer S. Author information: (1)Department of Clinical Epidemiology and Biostatistics, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands. OBJECTIVE: The purpose of this study was to evaluate the effect of evening primrose oil and fish oil on breast pain in premenopausal women with severe chronic mastalgia, in a randomized double-blind factorial clinical trial. STUDY DESIGN: One hundred twenty women were placed randomly into four groups: (1) fish oil and control oil, (2) evening primrose oil and control oil, (3) fish and evening primrose oils, or (4) both control oils during 6 months. Corn oil and corn oil with wheat germ oil were used as control oils. The change in the percentage of days with breast pain after 6 months of treatment was analyzed on an intention-to-treat basis. RESULTS: The decrease in days with pain was 12.3 % for evening primrose oil and 13.8% for its control oil (P =.73); the decrease in days with pain was 15.5% for fish oil and 10.6% for its control oil (P =.28). CONCLUSION: All groups showed a decrease in pain. Neither evening primrose oil nor fish oil offered clear benefit over control oils in the treatment of mastalgia. DOI: 10.1067/mob.2002.127377a PMID: 12439536 [Indexed for MEDLINE]
12. Am J Med Sci. 1994 Jul;308(1):16-22. doi: 10.1097/00000441-199407000-00005. Lack of effects of beta-carotene on lipids and sex steroid hormones in hyperlipidemics. Hughes GS Jr(1), Ringer TV, Francom SF, Means LK, DeLoof MJ. Author information: (1)Upjohn Company, Upjohn Research Clinics, Kalamazoo, MI 49001. Beta-carotene in doses of up to 300 mg daily raises high-density lipoprotein cholesterol levels within 2 to 4 weeks in healthy subjects. The authors, in this study, investigate the short-term effects of high-dose beta-carotene upon serum lipids, lipoproteins, and selected sex steroid hormones in 59 adult patients with Type IIa or IIb hyperlipidemia and 36 healthy subjects. Volunteers took beta-carotene (300 mg) or wheat germ oil capsules daily for 30 days. Lipids were measured on days 1, 14, 21, and 30. Beta-carotene, retinol, free and total testosterone, and estradiol levels were measured on days 1 and 30. Total high-density lipoprotein cholesterol levels increased 10% (p < 0.01) over baseline in all groups by day 14 but returned to baseline by day 30. Total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels transiently increased between days 14 and 21 by up to 9%, 8%, and 20%, respectively, only in the patients with hyperlipidemia treated with beta-carotene, but returned to baseline on day 30. Apolipoproteins A and B were unchanged. Despite 20-fold increases of plasma beta-carotene levels there, were no reports of carotenodermia and no alteration in sex steroid hormones, retinol levels, hepatic transaminases, or persistent changes in serum lipids that were attributable to beta-carotene. DOI: 10.1097/00000441-199407000-00005 PMID: 8010332 [Indexed for MEDLINE]
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